Search results for "Positive"
showing 10 items of 1875 documents
Counterdispositional Conscientiousness and Wellbeing: How Does Acting Out of Character Relate to Positive and Negative Affect at Work?
2020
Conscientiousness is typically seen as a positive or desired personality trait in the workplace, with the overall assumption being “the more, the better”. Drawing on the behavioral concordance model, we challenge this assumption, expecting that the highest level of positive affect and the lowest level of negative affect will correspond at the point where state and trait conscientiousness converge. Using an experience sampling study and an event reconstruction study, we show that deviations from one’s level of trait conscientiousness relate to variations in positive and negative affect, but not in a straightforward way. While wellbeing was lower when people behaved less conscientiously than …
Music Listening for Supporting Adolescents’ Sense of Agency in Daily Life
2020
Sense of agency refers to the ability to influence one’s functioning and environment, relating to self-efficacy and wellbeing. In youth, agency may be challenged by external demands or redefinition of self-image. Music, having heightened relevance for the young, has been argued to provide feelings of self-agency for them. Yet, there is little empirical research on how music impacts adolescents’ daily sense of agency. The current study investigated whether music listening influences adolescents’ perceived agency in everyday life and which individual and contextual determinants would explain such an influence. Participants were 44 adolescents (48% female, 36% with training in music, mean age …
Extensions of positive linear functionals on a *-algebra
2010
The family of all extensions of a nonclosable hermitian positive linear functional defined on a dense *-subalgebra $\Ao$ of a topological *-algebra $\A[\tau]$ is studied with the aim of finding extensions that behave regularly. Under suitable assumptions, special classes of extensions (positive, positively regular, absolutely convergent) are constructed. The obtained results are applied to the commutative integration theory to recover from the abstract setup the well-known extensions of Lebesgue integral and, in noncommutative integration theory, for introducing a generalized non absolutely convergent integral of operators measurable w. r. to a given trace $\sigma$.
A neoepitope generated by an FLT3 internal tandem duplication (FLT3-ITD) is recognized by leukemia-reactive autologous CD8+ T cells.
2006
Abstract The FLT3 receptor tyrosine kinase is expressed in more than 90% of acute myelogeneous leukemias (AMLs), up to 30% of which carry an internal tandem duplication (ITD) within the FLT3 gene. Although varying duplication sites exist, most FLT3-ITDs affect a single protein domain. We analyzed the FLT3-ITD of an AML patient for encoding HLA class I–restricted immunogenic peptides. One of the tested peptides (YVDFREYEYY) induced in vitro autologous T-cell responses restricted by HLA-A*0101 that were also detectable ex vivo. These peptide-reactive T cells recognized targets transfected with the patient's FLT3-ITD, but not wild-type FLT3, and recognized the patient's AML cells. Our results …
Towards humane digitization : a wellbeing-driven process of personas creation
2019
Digital transformation is a process of digitizing the working and living environment in which people are at the center of digitization. In this paper, we present a personas-based guideline for system developers on how the humanization of digital transformation integrates into the design process. The proposed guideline uses the positive personas from the beginning as a basis for the transformation of the working environment into the digital form. We used the literature research as a preliminary study for the process of wellbeing-driven digital transformation design, consisting of questions for structuring the required information in the positive personas as well as a potential method that co…
The overstated generational gap in online news use? A consolidated infrastructural perspective
2021
Recent research by Taneja et al. suggested that digital infrastructures diminish the generational gap in news use by counteracting preference structures. We expand on this seminal work by arguing that an infrastructural perspective requires overcoming limitations of highly aggregated web tracking data used in prior research. We analyze the individual browsing histories of two representative samples of German Internet users collected in 2012 ( N = 2970) and 2018 ( N = 2045) and find robust evidence for a smaller generational gap in online news use than commonly assumed. While short news website visits mostly demonstrated infrastructural factors, longer news use episodes were shaped more by …
Bildungsexpansion, soziale Klasse und die Wahl von Latein als Strategie der Distinktion
2021
In times of educational expansion, privileged families are looking for new strategies of distinction. Referring to Pierre Bourdieu���s theory of distinction, we argue that choosing Latin at school ��� a language that is no longer spoken and therefore has no direct value ��� is one of the strategies of privileged families to set themselves apart from less privileged families. Based on two surveys we conducted at German schools, the paper analyzes the relationship between parents��� educational background and the probability that their child will learn Latin. Results indicate that historically academic families have the strongest tendency towards learning Latin, followed by new academic famil…
Confidence-based Somatic Mutation Evaluation and Prioritization
2012
Next generation sequencing (NGS) has enabled high throughput discovery of somatic mutations. Detection depends on experimental design, lab platforms, parameters and analysis algorithms. However, NGS-based somatic mutation detection is prone to erroneous calls, with reported validation rates near 54% and congruence between algorithms less than 50%. Here, we developed an algorithm to assign a single statistic, a false discovery rate (FDR), to each somatic mutation identified by NGS. This FDR confidence value accurately discriminates true mutations from erroneous calls. Using sequencing data generated from triplicate exome profiling of C57BL/6 mice and B16-F10 melanoma cells, we used the exist…
General Principles for the Detection of Modified Nucleotides in RNA by Specific Reagents.
2021
Epitranscriptomics heavily rely on chemical reagents for the detection, quantification, and localization of modified nucleotides in transcriptomes. Recent years have seen a surge in mapping methods that use innovative and rediscovered organic chemistry in high throughput approaches. While this has brought about a leap of progress in this young field, it has also become clear that the different chemistries feature variegated specificity and selectivity. The associated error rates, e.g., in terms of false positives and false negatives, are in large part inherent to the chemistry employed. This means that even assuming technically perfect execution, the interpretation of mapping results issuin…
Synthesis and antibacterial activities of cadiolides A, B and C and analogues
2015
International audience; The one-pot multicomponent synthesis of natural butenolides named cadiolides A, B, C and analogues has been realized. The antibacterial structure activity relationship shows that the presence of phenolic hydroxyl groups and the number and position of bromine atoms on the different aromatic rings are important features for antibacterial activity, besides it was demonstrated the tolerance of both benzene and furan ring at position 3 of the butenolide nucleus. Furthermore, none of the most relevant antibacterial compounds showed any cytotoxicity in freshly isolated human neutrophils.