Search results for "Positive"
showing 10 items of 1875 documents
Estimation Of The Genetic Parameters Of Eight Soybean Varieties In The Wasegi Village At Prafi District Manokwari Regency
2020
This study aims to estimate genetic parameters including genetic diversity coefficient, phenotypic diversity coefficient, heritability value, and the correlation between the character of plants from eight soybean varieties. The research was conducted from August to December 2017, in the Wasafi Village of Prafi District, Manokwari Regency. The study was designed using Randomized Block Design (RBD) with 8 treatments of soybean varieties. Each treatment was repeated 4 times, to obtain 32 experimental units. The data obtained were analyzed using ANOVA and if it had a significant effect, it was further tested using the Duncan Multiple Range Test (DMRT) at the 95% level, through the Costat progra…
Immune characterization of the HBHA-specific response in Mycobacterium tuberculosis-infected patients with or without HIV infection.
2017
Introduction RD1-based Interferon-γ Release Assays (IGRAs) cannot distinguish latent from active tuberculosis (TB) disease. Conversely, a positive response to heparin-binding haemagglutinin (HBHA)-based IGRAs, among TB-infected subjects, correlates with Mycobacterium tuberculosis (Mtb) containment and low risk of TB progression. The aim of this study was to characterize HBHA-immune responses in HIV-infected and uninfected subjects with active TB or latent TB infection (LTBI). Methods 49 subjects were prospectively enrolled: 22 HIV-uninfected (13 TB, 9 LTBI) and 27 HIV-infected (12 HIV-TB, 15 HIV-LTBI). Whole blood and peripheral blood mononuclear cells were stimulated with HBHA and RD1 anti…
Detection of mammalian carcinogens with an immunological DNA synthesis-inhibition test.
1992
There is a close relationship between genotoxicity, mutagenicity and carcinogenicity. But the controversy of which short-term test system best recognizes human carcinogens is still going on. Currently, the Salmonella gene mutation assay ('Ames test') is the most widely used test for the screening of mutagens. However, many in vitro tests hold unsatisfactory validity data, presumably because of the inability of present short-term tests to detect non-genotoxic carcinogens, which are increasingly being brought into focus in the discussions of genesis of cancer. One principle often neglected in this context is the property of genotoxic agents to inhibit replicative DNA synthesis in (proliferati…
Epistasis between new mutations and genetic background and a test of genetic canalization.
2001
The importance for fitness of epistatic interactions among mutations is poorly known, yet epistasis can exert important effects on the dynamics of evolving populations. We showed previously that epistatic interactions are common between pairs of random insertion mutations in the bacterium Escherichia coli. In this paper, we examine interactions between these mutations and other mutations by transducing each of twelve insertion mutations into two genetic backgrounds, one ancestral and the other having evolved in, and adapted to, a defined laboratory environment for 10,000 generations. To assess the effect of the mutation on fitness, we allowed each mutant to compete against its unmutated cou…
A quick one-tube nested PCR-protocol for EPO transgene detection
2012
The practice of doping threatens fair competition in sports. With the very recent reports on successful gene therapies for several diseases, the likelihood for abuse of gene transfer techniques in elite sports is rapidly increasing. It is therefore very important to develop valid detection techniques for transgenic DNA (tDNA) with ultimate sensitivity and specificity. To date, three slightly different procedures have been reported to reliably detect tDNA with sufficiently high sensitivity. Two utilize a real-time PCR-based approach and one uses a primer-internal, intron-spanning PCR approach (spiPCR). The specificity and sensitivity of these techniques, however, is still a matter of debate.…
Theoretical foundations of empirical measures of freedom: a research challenge to liberal economists
2004
In this essay we ground the theoretical foundations of an empirical measure of the degree of freedom perceived by individuals on the Millian view of affirmation and development of individuality. We then discuss the implications of such a measure for policy and institutional design.
Environmental Sustainability Approaches and Positive Energy Districts: A Literature Review
2021
During the last decade, increasing attention has been paid to the emerging concept of Positive Energy Districts (PED) with the aim of pushing the transition to clean energy, but further research efforts are needed to identify design approaches optimized from the point of view of sustainable development. In this context, this literature review is placed, with a specific focus on environmental sustainability within innovative and eco-sustainable districts. The findings show that some sustainability aspects such as sustainable food, urban heat islands mitigation and co-impacts, e.g., green gentrification, are not adequately assessed, while fragmented thinking limits the potential of circularit…
Theoretical Approach: The Situation-Structural Model as an Analytical Tool to Explain Regionalism
2017
This chapter provides the analytical framework and guiding theory for this work. Muntschick develops an innovative situation-structural model to the analysis of regionalism that goes beyond Euro-centric and classic integration theories because it takes the impact of external actors explicitly into account. This—often neglected—aspect is of crucial importance in regions with mainly developing countries that show strong and asymmetric relations to extra-regional actors. Besides offering clear-cut definitions of regions and regionalism, Muntschick draws on insights from cooperation and regime theory in order to specify assumptions and deduce hypotheses about the emergence, institutional design…
Positive Youth Development in Bulgaria, Italy, Norway and Romania: Testing the Factorial Structure and Measurement Invariance of the 5Cs Model
2021
This chapter applies the 5Cs model of PYD comprising competence, confidence, character, connection and caring among 1403 youth (M = 18.91 years) in Bulgaria (n = 196), Italy (n = 354), Norway (n = 564) and Romania (n = 289). These countries offer a novel and unique context to apply PYD as related comparative work with youth samples is rare across Eastern (Bulgaria and Romania), Southern (Italy) and Northern Europe (Norway). Further, Bulgaria and Romania are emerging nations following the collapse of the communism in late 1980s in contrast to Italy being a traditionally patriarchal country and social equity driven Norway. The chapter presents an empirical example that evaluates the factorial…
Health capital in everyday life of the oldest old living in their own homes
2014
ABSTRACTAs more people experience old age as a time of growth and productivity, more research is needed that explores how they master everyday life. This paper reports on a qualitative study that explored how ten older women age 90 years or more experience and cope with the challenges of everyday life with a salutogenic perspective. The findings suggest that health resources such as positive expectation, reflection and adaptation, function and active contribution, relations and home, contribute to the health capital of women. These health resources were of importance for the women's experience of comprehensibility, manageability and meaningfulness in daily life. Health capital is a meaningf…