Search results for "Precancer"

showing 2 items of 92 documents

Expression of 60-kD Heat Shock Protein Increases during Carcinogenesis in the Uterine Exocervix

2002

<i>Objectives:</i> The aim of the present study was to determine the presence and expression of the 60-kD heat shock protein (HSP60) in the dysplasia-carcinoma sequence in the uterine exocervix and to evaluate its diagnostic and prognostic significance. <i>Methods and Results:</i> We performed Western blot and immunohistochemical analyses on biopsies from 40 cases, consisting of 10 normal exocervical biopsies, 10 low-grade squamous intraepithelial lesions (L-SIL), 10 high-grade squamous intraepithelial lesions (H-SIL) and 10 cancerous exocervices (G2 grade). The immunohistochemical results were quantified by computer-assisted image analysis. Western blot analysis sho…

musculoskeletal diseasesKoilocytePathologymedicine.medical_specialtyChaperonin; High-grade squamous intraepithelial lesion; Koilocyte; Low-grade squamous intraepithelial lesion; Squamous cervical cancer; 2734; Clinical Biochemistry; Immunology and Allergy; Cell BiologyBlotting Western2734Clinical BiochemistryUterine Cervical NeoplasmsBiologyChaperoninPathology and Forensic MedicineWestern blotimmune system diseasesLow-grade squamous intraepithelial lesionhemic and lymphatic diseasesHeat shock proteinImage Processing Computer-AssistedmedicineCarcinomaHumansImmunology and AllergyMolecular Biologymedicine.diagnostic_testChaperonin 60Cell BiologyGeneral MedicinePrognosisUterine Cervical Dysplasiamedicine.diseaseImmunohistochemistryMolecular biologyfemale genital diseases and pregnancy complicationsKoilocyteEpitheliumBlotmedicine.anatomical_structureHigh-grade squamous intraepithelial lesionCarcinoma Squamous CellImmunohistochemistryFemalePrecancerous ConditionsSquamous cervical cancerImmunostainingPathobiology
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Oral lichenoid disease as a premalignant condition : the controversies and the unknown

2009

We grouped as oral lichenoid disease (OLD) a series of chronic inflammatory processes with autoimmune base that affect the epithelium of the oral mucosa. This disease presents in 2% of the population with a marked predilection for the female gender, especially perimenopausal women. Clinically, it is characterized by the presence of lineal reticular papules and histologically by liquefaction degeneration of the basal layer of the epithelium associated with an inflammatory infiltrate with a "band-like" disposition on the lamina propria, composed primarily of T lymphocyte cells. Its pathogenicity is associated with deregulation of the cellular immune system, where the activated cytotoxic CD8 a…

stomatognathic diseasesPrecancerous conditionsDiseases -- Causes and theories of causationUNESCO::CIENCIAS MÉDICASMouth -- Diseases -- Diagnosis:CIENCIAS MÉDICAS [UNESCO]Lichen Planus Oral
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