Search results for "Prediabetic State"

showing 8 items of 28 documents

Impact of direct acting antivirals (DAAs) on cardiovascular events in HCV cohort with pre-diabetes

2021

Background and aims: Beyond type 2 diabetes, even a condition of prediabetes is associated with an increased cardiovascular (CV) risk, and HCV infection coexistence represents an exacerbating factor. CV prognosis improvement in prediabetes represents a challenge, due to the increasing prevalence of this metabolic condition worldwide. Hence, we aimed to prospectively assess how direct acting antivirals (DAAs) could affect major cardiovascular events (MACE) in a prediabetic HCV positive cohort. Methods and results: In this prospective multicenter study, we enrolled HCV patients with overt prediabetes. We compared a subgroup of patients treated with DAAs with untreated prediabetic controls. We…

MaleTime FactorsEndocrinology Diabetes and MetabolismCardiovascular risk Direct acting antiviralsHepatitis C virusPrediabetes Aged Antiviral Agents Cardiovascular Diseases FemaleHeart Disease Risk Factors Hepatitis C Humans Incidence Italy Longitudinal Studies Male Middle Aged Prediabetic State Prospective Studies Protective Factors Retrospective Studies Risk AssessmentTime Factors Treatment Outcome Viral LoadMedicine (miscellaneous)Type 2 diabetes030204 cardiovascular system & hematologymedicine.disease_causeDIRECT ACTING ANTIVIRALSLiver disease0302 clinical medicineLongitudinal StudiesProspective StudiesPrediabeteseducation.field_of_studyNutrition and DieteticsIncidenceMiddle AgedViral LoadHepatitis CTreatment OutcomeItalyCardiovascular DiseasesCohortFemaleCardiology and Cardiovascular Medicinemedicine.medical_specialtyHepatitis C virusPopulation030209 endocrinology & metabolismAntiviral AgentsRisk AssessmentPrediabetic State03 medical and health sciencesInternal medicinemedicineHumanseducationAgedRetrospective Studiesbusiness.industryProtective FactorsCardiovascular riskmedicine.diseaseHeart Disease Risk FactorsDirect acting antiviralHepatitis C virubusinessPrediabetesMace
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Increased insulin-stimulated glucose uptake in both leg and arm muscles after sprint interval and moderate-intensity training in subjects with type 2…

2017

We investigated the effects of sprint interval training (SIT) and moderate-intensity continuous training (MICT) on glucose uptake (GU) during hyperinsulinemic euglycemic clamp and fatty acid uptake (FAU) at fasting state in thigh and arm muscles in subjects with type 2 diabetes (T2D) or prediabetes. Twenty-six patients (age 49, SD 4; 10 women) were randomly assigned into two groups: SIT (n=13) and MICT (n=13). The exercise in the SIT group consisted of 4–6×30 s of all-out cycling with 4- minute recovery and in the MICT group 40- to 60- minute cycling at 60% of VO2peak. Both groups completed six training sessions within two weeks. GU and FAU were measured before and after the intervention wi…

Malemedicine.medical_specialty030209 endocrinology & metabolismPhysical Therapy Sports Therapy and RehabilitationType 2 diabetesThighBicepsInterval trainingPrediabetic State03 medical and health sciences0302 clinical medicineInsulin resistanceOxygen ConsumptionInternal medicinemedicineHumansInsulinOrthopedics and Sports MedicinePrediabetesta315Muscle SkeletalExerciseLegbusiness.industrySkeletal muscle030229 sport sciencesta3121Middle Agedmedicine.diseasemedicine.anatomical_structureGlucoseSprintDiabetes Mellitus Type 2CardiologyPhysical therapyArmBody CompositionGlucose Clamp TechniqueCarbohydrate MetabolismFemalebusinessPhysical Conditioning HumanScandinavian journal of medicinescience in sports
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Cacao extract enriched in polyphenols prevents endocrine-metabolic disturbances in a rat model of prediabetes triggered by a sucrose rich diet.

2019

Cocoa extracts rich in polyphenols are used as potential agent for treating diabetes. Cocoa polyphenols have been proved to ameliorate important hallmarks of type-2 diabetes (T2D). They can regulate glucose levels by increasing insulin secretion, promoting β-cell proliferation and a reduction of insulin resistance. In addition, epidemiological evidence indicates that consumption of flavonoid decreases the incidence of T2D.T2D is preceded by a prediabetic state in which the endocrine-metabolic changes described in T2D are already present. Since epidemiological evidence indicates that consumption of flavonoid decreases its incidence, we evaluated possible preventive effects of polyphenol-enri…

Malemedicine.medical_specialtymedicine.disease_causePrediabetic State03 medical and health scienceschemistry.chemical_compound0302 clinical medicineInsulin resistanceDietary SucroseInternal medicineDiabetes mellitusDrug DiscoverymedicineAnimalsHumansPrediabetesTriglycerides030304 developmental biologyPharmacology0303 health sciencesCacaoGlycogenPlant ExtractsCocoa ExtractHypertriglyceridemiafood and beveragesPolyphenolsGlutathionemedicine.diseaseRatsDisease Models AnimalOxidative StressEndocrinologychemistryDiabetes Mellitus Type 2Liver030220 oncology & carcinogenesisInsulin ResistanceOxidative stressJournal of ethnopharmacology
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Glucagon-Like Peptide-1 Receptor Agonists and Dual Glucose-Dependent Insulinotropic Polypeptide/Glucagon-Like Peptide-1 Receptor Agonists in the Trea…

2022

The obesity pandemic is accompanied by increased risk of developing metabolic syndrome (MetS) and related conditions: non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH), type 2 diabetes mellitus (T2DM) and cardiovascular (CV) disease (CVD). Lifestyle, as well as an imbalance of energy intake/expenditure, genetic predisposition, and epigenetics could lead to a dysmetabolic milieu, which is the cornerstone for the development of cardiometabolic complications. Glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) and dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 RAs promote positive effects on most components of the “ cardiometabolic continuum” an…

Metabolic SyndromePharmacologyglucagon-like peptide-1 receptor agonists glucose-dependent insulinotropic polypeptide receptor agonists non-alcoholic fatty liver disease obesity prediabetes tirzepatide type 2 diabetes mellitusGlucagon-Like Peptide-1 ReceptorPrediabetic StateGlucoseDiabetes Mellitus Type 2Non-alcoholic Fatty Liver DiseaseGlucagon-Like Peptide 1HumansPharmacology (medical)ObesityPeptidesCardiology and Cardiovascular MedicineJournal of Cardiovascular Pharmacology and Therapeutics
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A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease

2021

AbstractExercise and diet are treatments for nonalcoholic fatty liver disease (NAFLD) and prediabetes, however, how exercise and diet interventions impact gut microbiota in patients is incompletely understood. We previously reported a 8.6-month, four-arm (Aerobic exercise, n = 29; Diet, n = 28; Aerobic exercise + Diet, n = 29; No intervention, n = 29) randomized, singe blinded (for researchers), and controlled intervention in patients with NAFLD and prediabetes to assess the effect of interventions on the primary outcomes of liver fat content and glucose metabolism. Here we report the third primary outcome of the trial—gut microbiota composition—in participants who completed the trial (22 i…

MultidisciplinaryMicrobiotasuolistomikrobistoGeneral Physics and AstronomyGeneral Chemistryinterventiotutkimussatunnaistetut vertailukokeetGeneral Biochemistry Genetics and Molecular BiologyDietPrediabetic StateLiverNon-alcoholic Fatty Liver Diseaseei-alkoholiperäinen rasvamaksasairausHumansExerciseravitsemushoitoliikuntahoito
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Low physical activity and its association with diabetes and other cardiovascular risk factors: a nationwide, population-based study

2016

Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM; ISCIII Ministerio de Ciencia e Innovacion); Ministerio de Sanidad y Consumo; Spanish Diabetes Society (SED)

QuestionnairesMaleDislipidemiasCross-sectional studyEstudios transversalesEspañaObesidadÍndice de masa corporalBiochemistryBody Mass Index0302 clinical medicineEndocrinology:Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Motor Activity [Medical Subject Headings]Public and Occupational Healthlcsh:Science:Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet::Diet Mediterranean [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence [Medical Subject Headings]:Chemicals and Drugs::Lipids::Glycerides::Triglycerides [Medical Subject Headings]:Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings]Aged 80 and overDiabetis:Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Lipid Metabolism Disorders::Dyslipidemias [Medical Subject Headings]:Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight::Obesity::Obesity Abdominal [Medical Subject Headings]Cardiovascular DiseasesObesitatEnfermedades cardiovascularesFactores de riesgomedicine.medical_specialtyEndocrine Disorders:Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins HDL::Cholesterol HDL [Medical Subject Headings]:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Habits::Smoking [Medical Subject Headings]QüestionarisTriglicéridosExercici -- Aspectes sanitaris03 medical and health sciencesDiabetes MellitusHumans:Diseases::Cardiovascular Diseases [Medical Subject Headings]ExerciseAgedSurvey ResearchMalalties cardiovascularsPreventionlcsh:REnfermedad crónicaBiology and Life SciencesPhysical ActivityInsulin-resistancemedicine.diseaseActividad motoraObesityLipid metabolismCross-Sectional StudiesDyslipidemiaAdherenceGlucosalcsh:QBody mass indexDyslipidemiaDemography:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Psychology Social::Life Style::Sedentary Lifestyle [Medical Subject Headings]PhysiologyPhysical fitnessSistema cardiovascular -- Malalties:Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::Glucose [Medical Subject Headings]lcsh:Medicine:Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight::Obesity [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings]Obesidad abdominalGeographical LocationsGlucose MetabolismRisk FactorsHábito de fumarMedicine and Health SciencesPrevalence030212 general & internal medicinePrediabetes:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Surveys and Questionnaires [Medical Subject Headings]Multidisciplinary:Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Disease Attributes::Chronic Disease [Medical Subject Headings]DiabetesMiddle Aged:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings]EuropeEncuestas y cuestionariosPhysiological ParametersResearch DesignCarbohydrate MetabolismFemaleResearch ArticleAdultAdolescent030209 endocrinology & metabolismVida sedentariaResearch and Analysis MethodsHDL-colesterolYoung AdultSex FactorsDiabetes mellitusmedicineAdultsObesityEspanya:Diseases::Endocrine System Diseases::Diabetes Mellitus::Prediabetic State [Medical Subject Headings]Sedentary lifestylebusiness.industryEstado prediabéticoBody WeightPhysical fitnessDieta mediterráneaMetabolisme dels lípidsDietMetabolismSpainMetabolic DisordersPeople and PlacesPhysical therapySedentary BehaviorbusinessPrevalenciaCondició física
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The impact of Nordic walking on bone properties in postmenopausal women with pre-diabetes and non-alcohol fatty liver disease

2021

This study investigated the impact of Nordic walking on bone properties in postmenopausal women with pre-diabetes and non-alcohol fatty liver disease (NAFLD). A total of 63 eligible women randomly participated in the Nordic walking training (AEx, n = 33), or maintained their daily lifestyle (Con, n = 30) during intervention. Bone mineral content (BMC) and density (BMD) of whole body (WB), total femur (TF), femoral neck (FN), and lumbar spine (L2-4) were assessed by dual-energy X-ray absorptiometry. Serum osteocalcin, pentosidine, receptor activator of nuclear factor kappa-B ligand (RANKL) levels were analyzed by ELISA assay. After an 8.6-month intervention, the AEx group maintained their BM…

naisetHealth Toxicology and MutagenesisEndocrinology Diabetes and Metabolismpostmenopausal womenbiomarkkeritAlcoholDiseases of the musculoskeletal systemWalkingDiseasesauvakävelychemistry.chemical_compound0302 clinical medicineAbsorptiometry PhotonBone DensityNon-alcoholic Fatty Liver DiseaseOrthopedics and Sports Medicine030212 general & internal medicineNordic walkingOsteoporosis PostmenopausalbiologykuntoliikuntaFemur Neckmusculoskeletal neural and ocular physiologyFatty liverRmusculoskeletal systemPostmenopausemedicine.anatomical_structureRANKLPre diabetesOsteocalcinMedicineFemaleikääntyneetmusculoskeletal diseasesmedicine.medical_specialtyluuntiheys030209 endocrinology & metabolismArticlePrediabetic State03 medical and health sciencesbone markersInternal medicinemedicineHumansFemurPentosidineFemoral neckPostmenopausal womenbusiness.industryPublic Health Environmental and Occupational Healthmedicine.diseaseEndocrinologyRC925-935chemistryei-alkoholiperäinen rasvamaksasairausbiology.proteinfatty liver diseasebone mineral densitybusinessaikuistyypin diabetesBone Reports
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Comparative analysis of socioeconomic, behavioral and biological factors between healthy patients and patients with newly diagnosed diabetes in the L…

2020

Introduction. The most effective way to prevent a dramatic increase in the number of diabetic patients lies in early detection of its risk factors and the diagnosis of carbohydrate metabolism disorders. Aim of the study. The study aims at determining socio-economic variables, lifestyle behaviours and biological factors differentiating patients with newly diagnosed diabetes from the diabetes-free individuals according to the American criteria issued by the Commission on Social Determinants of Health as well as FINDRISC form which helps identify patients who are at risk of developing diabetes type 2 on the basis of multi-factorial determinants of its development. Material and methods. The res…

prediabetic statetype 2 diabetes mellituspatientsMedical Science Pulse
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