Search results for "Prefrontal"
showing 10 items of 329 documents
Revisiting the left convexity hypothesis: changes in the mental apparatus after left dorso-medial prefrontal damage
2016
It has been 15 years since Kaplan-Solms and Solms published their Clinical Studies in Neuropsychoanalysis, where they proposed a neuroanatomy of the mental apparatus. One of their main observations was that damage to certain areas of the left prefrontal cortex (PFC), particularly those related to expressive language (Broca’s area), did not generate changes in the mental apparatus. However, a limitation of their model was that it did not include patients with damage to other areas of the left PFC. The main goal of this paper is to update Kaplan-Solms and Solms’ model through the description of id, ego and superego changes in a case of left dorso-medial prefrontal damage (Professor F). Data f…
Fronto-parietal homotopy in resting-state functional connectivity predicts task-switching performance
2021
Homotopic functional connectivity reflects the degree of synchrony in spontaneous activity between homologous voxels in the two hemispheres. Previous studies have associated increased brain homotopy and decreased white matter integrity with performance decrements on different cognitive tasks across the life-span. Here, we correlated functional homotopy, both at the whole-brain level and specifically in fronto-parietal network nodes, with task-switching performance in young adults. Cue-to-target intervals (CTI: 300 vs. 1200 ms) were manipulated on a trial-by-trial basis to modulate cognitive demands and strategic control. We found that mixing costs, a measure of task-set maintenance and moni…
Altered brain levels of arachidonic acid-derived inflammatory eicosanoids in a rodent model of anorexia nervosa
2019
Increasing evidence underline the role of inflammation in the behavioral, emotional and cognitive dysregulations displayed in anorexia nervosa (AN). Among the inflammatory mediators acting at both peripheral and central levels, growing attention receives a class of lipids derived from arachidonic acid (AA), called eicosanoids (eiCs), which exert a complex, multifaceted role in a wide range of neuroinflammatory processes, peripheral inflammation, and generally in immune system function. To date, little is known about their possible involvement in the neurobiological underpinnings of AN. The present study evaluated whether the activity-based model of AN (ABA) may alter AA-metabolic pathways b…
Progression of adverse effects over consecutive sessions of transcranial direct current stimulation
2017
final draft
Gene expression of neuregulin-1 isoforms in different brain regions of elderly schizophrenia patients
2010
One important risk gene in schizophrenia is neuregulin-1 (NRG1), which is expressed in different isoforms in the brain. To determine if alterations of NRG1 are present in schizophrenia, we measured gene expression of NRG1 and its main isoforms as well as the impact of genetic variation of NRG1 in an exploratory study examining three brain regions instead of only one as published so far. In all, we examined post-mortem samples from 11 schizophrenia patients and eight normal subjects. We investigated gene expression of total NRG1 and isoforms I, II and III by real-time PCR in the prefrontal cortex (Brodmann areas 9 and 10) and right hippocampal tissue. For the genetic study, we genotyped the …
L'estimulació cerebral profunda al nucli accumbens i l'estudi pilot electrofisiològic d'escorça prefrontal medial, davant la resposta d'estrés
2015
Aquest estudi es basa, conceptualment, en les investigacions relatives a l'estimulació cerebral profunda (ECP), que és una intervenció neuroquirúrgica en la que elèctrodes implantats alliberen impulsos elèctrics en zones «diana» de l'encèfal. Aquesta tècnica ha estat emprada per a tractar diferents patologies, entre altres les addiccions i les seues manifestacions comportamentals. Específicament, l'ECP al nucli accumbens, ha estat aplicada per a tractar, amb èxit, els trastorns addictius i el desig del consum craving. Així mateix destaquem com durant el proces addictiu i, concretament, en el craving s'ha comprovat, que l'estrés juga un paper significatiu. D'altra banda, banda, l'estudi elec…
Effects of the Enriched Sports Activities-Program on Executive Functions in Italian Children.
2020
Physical activity (PA) during childhood plays an important role in brain development. This role is played in both the structural domain, prefrontal cortex area, and in the functional domain, involving the higher cognitive functions, including the executive functions (EF). Working memory (WM), inhibition, and switching as fundamental EF were investigated in an Italian children sample before and after four months of an Enriched Sports Activities-Program (ESA-Program). EFs were assessed at pre-test and post-test using, respectively, the digit span test, the color word Stroop test, and the trail making test derived from Millisecond Software. The Italian sample was composed of 141 children aged …
Behavioural and neurochemical effects after repeated administration of N-ethylpentylone (ephylone) in mice
2022
N-ethyl-pentylone (NEP), also known as "ephylone" and N-ethylnorpentylone, has been identified as one of the most recent novel psychostimulants to emerge into the illicit drug market and it has been associated with some intoxications and even fatalities. However, little is known about the consequences of its repeated consumption as well as the role of the monoaminergic system in such consequences. Thus, the aim of our study was to investigate the neurochemical profile and the behavioural effects after both acute and repeated NEP exposure. Male OF1 mice were acutely (1, 3, 10 mg/kg, i.p.) or repeatedly (1, 3, 10 mg/kg, i.p., 5 days, twice/day) exposed to NEP, and anxiety-like behaviour, aggr…
Causal brain-heart information transfer during visual emotional elicitation in healthy subjects: Preliminary evaluations and future perspectives
2017
Complex heartbeat dynamics is known to reflect subject's emotional state, thanks to numerous links to brain cortical and subcortical regions. Likewise, specific brain regions are deeply involved in vagally-mediated emotional processing and regulation. Nevertheless, although the brain-heart interplay has been studied during visual emotion elicitation, directional interactions have not been investigated so far. To fill this gap, in this study we investigate brain-heart dynamics during emotional elicitation in healthy subjects through measures of Granger causality (GC) between the two physiological systems. Data were gathered from 22 healthy volunteers who underwent pleasant/ unpleasant affect…
Early Social Isolation Stress and Perinatal NMDA Receptor Antagonist Treatment Induce Changes in the Structure and Neurochemistry of Inhibitory Neuro…
2017
AbstractThe exposure to aversive experiences during early life influences brain development and leads to altered behavior. Moreover, the combination of these experiences with subtle alterations in neurodevelopment may contribute to the emergence of psychiatric disorders, such as schizophrenia. Recent hypotheses suggest that imbalances between excitatory and inhibitory (E/I) neurotransmission, especially in the prefrontal cortex and the amygdala, may underlie their etiopathology. In order to understand better the neurobiological bases of these alterations, we studied the impact of altered neurodevelopment and chronic early-life stress on these two brain regions. Transgenic mice displaying fl…