Search results for "Presentation"
showing 10 items of 2405 documents
Enhanced susceptibility to cytotoxic T lymphocytes without increase of MHC class I antigen expression after conditional overexpression of heat shock …
1999
Antigenic peptides have been found associated with heat shock proteins (HSP) including cytoplasmic HSP70 and heat shock cognate protein 70 as well as the endoplasmic reticulum-resident glucose-regulated protein 94. Recently, HSP70 transfection has been reported to increase MHC class I cell surface expression and antigen presentation on mouse melanoma B16 cells (Wells et al., Int. Immunol. 1998. 10: 609). To analyze the effect of HSP70 on MHC class I cell surface expression and lysability of target cells we transfected a human melanoma cell line with the rat Hsp70-1 gene using the Tet-On system for conditional overexpression of HSP70. Induction of HSP70 did not increase cell surface expressi…
Targeting positive regulatory domain I-binding factor 1 and X box-binding protein 1 transcription factors by multiple myeloma-reactive CTL.
2005
Abstract Growing evidence indicates that multiple myeloma (MM) and other malignancies are susceptible to CTL-based immune interventions. We studied whether transcription factors inherently involved in the terminal differentiation of mature B lymphocytes into malignant and nonmalignant plasma cells provide MM-associated CTL epitopes. HLA-A*0201 (A2.1) transgenic mice were used to identify A2.1-presented peptide Ag derived from the plasma cell-associated transcriptional regulators, positive regulatory domain I-binding factor 1 (PRDI-BF1) and X box-binding protein 1 (XBP-1). A2.1-restricted CTL specific for PRDI-BF1 and XBP-1 epitopes efficiently killed a variety of MM targets. PRDI-BF1- and X…
The sequence alteration associated with a mutational hotspot in p53 protects cells from lysis by cytotoxic T lymphocytes specific for a flanking pept…
1998
A high proportion of tumors arise due to mutation of the p53 tumor suppressor protein. A p53 hotspot mutation at amino acid position 273 from R to H, flanking a peptide epitope that spans residues 264–272, renders cells resistant to killing by human histocompatibility leukocyte antigen (HLA)-A*0201–restricted cytotoxic T lymphocytes (CTLs) specific for this epitope. Acquisition of the R to H mutation at residue 273 of the human p53 protein promotes tumor growth in vivo by selective escape from recognition by p53.264–272 peptide-specific CTLs. Synthetic 27-mer p53 polypeptides covering the antigenic nonamer region 264–272 of p53 were used as proteasome substrates to investigate whether the R…
The Slovak Nation: From Czechoslovakia to Slovakia
2009
This chapter differs in composition from the two previous ones devoted to the politics of language in Hungary and Czechoslovakia in the short 20th century. With the exception of the brief wartime interlude of independent Slovakia (1939–1945), the Slovak nation found itself residing in Czechoslovakia between 1918 and 1992. This necessitated the representation of much Slovak history, and the vicissitudes of Czech-Slovak relations in the previous chapter, which nominally was devoted to matters Czech. It would soon be demonstrated that the past of the common state of the Czech and Slovaks could not be seamlessly divided into separate Czech and Slovak parts. Likewise, numerous international even…
Representaciones de la infancia en Cuerda de presas: trazos de identidad
2014
Los sucesos de la guerra civil española y de la inmediata posguerra constituyen de un tiempo a esta parte un foco de interés para las artes, especialmente para la literatura. El conjunto de relatos allí enmarcados se convierte en un fenómeno de interés para la crítica especializada que, desde distintas perspectivas vertebradas principalmente en torno a los debates acerca de la memoria, cuestiona y aborda la representación de estos acontecimientos históricos, herida aún abierta en la sociedad española. Una forma discursiva que circula todavía por los márgenes es la historieta, y Cuerda de presas es un libro de historietas que reúne once relatos sobre la guerra civil española. En las siguient…
Energy-related optimal control accounts for gravitational load: comparing shoulder, elbow, and wrist rotations.
2013
International audience; Gaveau J, Berret B, Demougeot L, Fadiga L, Pozzo T, Papaxanthis C. Energy-related optimal control accounts for gravitational load: comparing shoulder, elbow, and wrist rotations. J Neurophysiol 111: 4-16, 2014. First published October 16, 2013; doi: 10.1152/jn.01029.2012.-We permanently deal with gravity force. Experimental evidences revealed that moving against gravity strongly differs from moving along the gravity vector. This directional asymmetry has been attributed to an optimal planning process that optimizes gravity force effects to minimize energy. Yet, only few studies have considered the case of vertical movements in the context of optimal control. What kin…
Dynamic Perception of Plastic Movements: Biomechanics and Digital Artifacts
2017
The article offers some reflections on the body-space relationship through images, graphic translations and visual studies that converge into a contemporary digital illuminated avant-garde of the fourth virtual dimension. Starting from the study of the Soviet coreutics of the 1920s and the biomechanics of multimedia performances, it moves on the cinesthetic suggestions and to the dance theorization integrated with the musical score. Finally, some contemporary forms of digital image production are taken into account by addressing a number of issues regarding the exploration of the object-image and its experiential re-elaboration through the production of new graphic knowledge.
Tourism as a Form of New Psychological Resilience: The Inception of Dark Tourism
2012
Tourism industry is considered as an activity based on higher tolerance to frustration, in other terms as a resilient industry. At some extent, the diverse threats that impinge on tourism in late modernity not only did not alter its logic, but strengthened its presence worldwide. Concepts as dark tourism or thanatourism started to be adopted and applied in tourism-related research. Nonetheless, these studies are not interested in revealing neither the anthropological roots of the issue nor the representation of founding trauma (as sacralisation of the dead). Natural and made-man disasters give lessons to communities that are rechanneled by means of mythical mechanism of resiliency. Tourism,…
Parameter Rating by Diffusion Gradient
2014
Anomaly detection is a central task in high-dimensional data analysis. It can be performed by using dimensionality reduction methods to obtain a low-dimensional representation of the data, which reveals the geometry and the patterns that exist and govern it. Usually, anomaly detection methods classify high-dimensional vectors that represent data points as either normal or abnormal. Revealing the parameters (i.e., features) that cause detected abnormal behaviors is critical in many applications. However, this problem is not addressed by recent anomaly-detection methods and, specifically, by nonparametric methods, which are based on feature-free analysis of the data. In this chapter, we provi…
Event-based encoding from digital magnetic compass and ultrasonic distance sensor for navigation in mobile systems
2016
Event-based encoding reduces the amount of generated data while keeping relevant information in the measured magnitude. While this encoding is mostly associated with spiking neuromorphic systems, it can be used in a broad spectrum of tasks. The extension of event-based data representation to other sensors would provide advantages related to bandwidth reduction, lower computing requirements, increased processing speed and data processing. This work describes two event-based encoding procedures (magnitude-event and rate-event) for two sensors widely used in industry, especially for navigation in mobile systems: digital magnetic compass and ultrasonic distance sensor. Encoded data meet Address…