Search results for "Pressure"
showing 10 items of 4493 documents
Sequential dissociation of insulin amyloids probed by high pressure Fourier transform infrared spectroscopy
2012
High Pressure (HP) Fourier Transform Infrared Spectroscopy (FTIR) has been here employed to investigate the thermodynamic stability of bovine pancreatic insulin (BPI) amyloids. Once the aggregation reaction has started, the backbone arrangement of the proteins forming the amyloid is known to reach a stationary phase in few hours; after this time the infrared absorption of fibrils becomes stable. It is here shown how the further stabilization of the structure during the stationary phase can be probed via FTIR spectroscopy, through the observation of the high pressure behaviour of fibrils formed at different maturation stages. We report on the high pressure fragmentation of insulin amyloids, …
FTIR analysis of the high pressure response of native insulin assemblies
2013
It is widely recognized that a central role in conferring stability to the structure of proteins against misfolding and aggregation is played by the formation of oligomers. The case of insulin is prototypical in this respect: in our body it is stored up in stable inactive hexameric assemblies whereas only in its monomeric form it recovers the role of regulating carbohydrate and fat metabolism. In the present paper, exploiting the optimal coupling between FTIR spectroscopy and diamond anvil cell technique, we probe the stability of different insulin oligomeric forms under high pressure, namely over the ranges 0-15 kbar for water solution and 0-80 kbar for dry powder. Results obtained show di…
La resistenza di interfaccia calcestruzzo poroso-terreni a grana fina per il consolidamento di pendii mediante trincee drenanti profonde
2022
Le trincee drenanti profonde rappresentano uno dei metodi più efficaci per la mitigazione del rischio da frana, in pendii con falda idrica. Esse sono realizzate mediante pannelli o pali secanti. Il riempimento è costituito di calcestruzzo poroso o materiale granulare. Se le trincee sono adeguatamente “innestate” nel terreno stabile e il materiale di riempimento ha sufficiente resistenza e rigidezza come il calcestruzzo poroso, si ha ulteriore in-cremento di resistenza a taglio per effetto shear keys, oltre a quello derivante dalla riduzione delle pressioni in-terstiziali. L’incremento di resistenza è dovuto sia alla resistenza all’interfaccia calcestruzzo–terreni sia a quella intrinseca del…
Effects of a computerized decision support system on care planning for pressure ulcers and malnutrition in nursing homes: an intervention study.
2013
Author's accepted version (post-print). Background: Nursing documentation is essential for facilitating the flow of information to guarantee continuity, quality and safety in care. High-quality nursing documentation is frequently lacking; the implementation of computerized decision support systems is expected to improve clinical practice and nursing documentation. Aim: The present study aimed at investigate the effects of a computerized decision support system and an educational program as intervention strategies for improved nursing documentation practice on pressure ulcers and malnutrition in nursing homes. Design, setting and participants: An intervention study with two intervention grou…
La Sindrome Compartimentale Addominale (ACS) dopo chirurgia dell'Aneurisma dell'Aorta Addominale (AAA)
2009
Introduction: The Abdominal Compartment Syndrome (ACS) is a “condition in which increased tissue pressure in a confined anatomic space, causes decreased blood flow leading to ischaemia and dysfunction and may lead to permanent impairment of function” Materials and Methods: between june 2007 and june 2008 we treated surgically 23 cases of AAA (14 in election and 9 in emergency), with indirect intra-abdominal pressure (IAP) monitoring (intra-vescical catheter). Mean age was 68 (64-84) years. Mean transverse diameter was 6,2 cm (min 5,5 e max 9,0). Rise in IAP more then 20 mmHg was considered for surgical decompression. In 1 case we registered preoperatively IAP more than 20 mmHg treated with …
Pressure-Induced Deformation of Pillar-Type Profiled Membranes and Its Effects on Flow and Mass Transfer
2019
In electro-membrane processes, a pressure difference may arise between solutions flowing in alternate channels. This transmembrane pressure (TMP) causes a deformation of the membranes and of the fluid compartments. This, in turn, affects pressure losses and mass transfer rates with respect to undeformed conditions and may result in uneven flow rate and mass flux distributions. These phenomena were analyzed here for round pillar-type profiled membranes by integrated mechanical and fluid dynamics simulations. The analysis involved three steps: (1) A conservatively large value of TMP was imposed, and mechanical simulations were performed to identify the geometry with the minimum pillar density…
Preliminary study on the unusual properties in the habitat of Ranunculetum baudotii in Central Europe
2011
Abstract The study examines the patches of the saltwater association Ranunculetum baudotii in a new, atypical site; i.e., located more than 400 km away from the Baltic coastal line. They were found in a karst spring, and were the first locality of the community identified in Poland. The water and sediments within the patches were analyzed chemically in the laboratory, but, conductivity, water temperature and O2 content were measured in the field. The spring was determined to be a relatively stable aquatic habitat, with a typical chemical composition of subterranean water (a prevalence of hydro-carbonate, calcium and magnesium ions), and rich, e.g., in nitrogen and phosphorus, and disturbed …
Brief interventions in counselling for nutrition and the prevalence of metabolic syndrome in primary care adult patients
2018
This research i) examined the influence of a brief nutrition-based intervention among primary care patients in changing nutrition and clinical values related to metabolic syndrome (study 1), and ii) assessed nutrition and the prevalence of metabolic syndrome and its clinical determinants among primary care patients in different sociodemographic groups (study 2). In study 1, a systematic literature review was conducted on eight databases during Sept.-Oct. 2016 with a final update in Nov. 2017. In study 2, data (n=557 for RO II-III, n=251 for RO IV-V) collected in primary care practices in Central Finland in 2006-2008 for the EVI study were analysed using Chi-Square test, GLM and Logistic Reg…
Competitive Pressure and Diversification into Green R&D
2019
Based on representative firm-level survey data for Austria, Germany, and Switzerland, we investigate the relationship between quick obsolescence of products, unpredictable technological development, and easy substitution of products and the probability to diversify into green R&D. We find that product obsolescence and technological uncertainty are positively related with green R&D diversification. These types of competition are usually positively related with low barriers to market entry. Hence, policies that support open markets should stimulate diversification into green R&D. peerReviewed
Effect of using cardiovascular risk scoring in routine risk assessment in primary prevention of cardiovascular disease: an overview of systematic rev…
2019
Background Our objectives were to critically appraise and summarise the current evidence for the effectiveness of using cardiovascular disease (CVD) risk scoring (total risk assessment - TRA) in routine risk assessment in primary prevention of CVD compared with standard care with regards to patients outcomes, clinical risk factor levels, medication prescribing, and adverse effects. Methods We carried out an overview of existing systematic reviews (SRs). Presentation of the results aligned guidelines from the PRISMA statement. The data is presented as a narrative synthesis. We searched MEDLINE (Ovid), EMBASE, CENTRAL and SCOPUS databases from January 1990 to March 2017, reviewed the referenc…