Search results for "Prevention"

Binge-Like, Naloxone-Sensitive, Voluntary Ethanol Intake at Adolescence Is Greater Than at Adulthood, but Does Not Exacerbate Subsequent Two-Bottle C…

2020

The present study assessed the effects of ethanol exposure during adolescence or adulthood. We exposed Wistar rats, males or females, to self-administered 8–10% (v/v) ethanol (BINGE group) during the first 2 h of the dark cycle, three times a week (Monday, Wednesday, and Friday) during postnatal days (PDs) 32–54 or 72–94 (adolescent and adults, respectively). During this period, controls were only handled, and a third (IP) condition was given ethanol intraperitoneal administrations, three times a week (Monday, Wednesday, and Friday), at doses that matched those self-administered by the BINGE group. The rats were tested for ethanol intake and preference in a two-bottle (24 h long) choice tes…

Lynch Syndrome Genetics and Clinical Implications

2023

Lynch syndrome (LS) is one of the most prevalent hereditary cancer syndromes in humans and accounts for some 3% of unselected patients with colorectal or endometrial cancer and 10%-15% of those with DNA mismatch repair-deficient tumors. Previous studies have established the genetic basis of LS predisposition, but there have been significant advances recently in the understanding of the molecular pathogenesis of LS tumors, which has important implications in clinical management. At the same time, immunotherapy has revolu-tionized the treatment of advanced cancers with DNA mismatch repair defects. We aim to review the recent prog-ress in the LS field and discuss how the accumulating epidemiol…

International consensus and practical guidelines on the gynecologic and obstetric management of female patients with hereditary angioedema caused by …

2012

Background There are a limited number of publications on the management of gynecologic/obstetric events in female patients with hereditary angioedema caused by C1 inhibitor deficiency (HAE-C1-INH). Objective We sought to elaborate guidelines for optimizing the management of gynecologic/obstetric events in female patients with HAE-C1-INH. Methods A roundtable discussion took place at the 6th C1 Inhibitor Deficiency Workshop (May 2009, Budapest, Hungary). A review of related literature in English was performed. Results Contraception : Estrogens should be avoided. Barrier methods, intrauterine devices, and progestins can be used. Pregnancy : Attenuated androgens are contraindicated and should …

Exercise as the master polypill of the 21st century for the prevention of cardiovascular disease

2015

To the Editor,The growing pandemic of cardiovascular diseases (CVD) has para-doxically paralleled advances in pharmacology, and CVD remains theleading cause of death worldwide. Therapeutic strategies aiming atcontrolling several CVD risk factors simultaneously in individualswithout evidence of CVD are expensive and difficult to implement.Thus, the development of fixed-dose drug combinations of antiplatelettogether with blood pressure (BP) and cholesterol-lowering drugs,i.e., polypills, is gaining attention to prevent CVD [1,2] and all-causemortality [3], even after an acute coronary syndrome [4]. Despite thepotential of polypills to increase adherence at a lower cost [5], peoplerandomized to …

Empirically Determined, Psychopathological Subtypes in Children With ADHD

2013

OBJECTIVE: The aim of this study was to empirically determine subgroups of ADHD defined by specific patterns of psychopathology. METHOD: A clinical sample of 223 children with ADHD, aged 5 to 14 years, was examined with the Child Behavior Checklist (CBCL). In addition, comorbid psychiatric disorders, psychosocial risk factors, and socioeconomic status were assessed. RESULTS: Cluster analysis of CBCL subscales yielded a solution with four distinct subgroups. While "externalizers" showed a high rate of comorbid oppositional defiant disorder (ODD) and conduct disorder (CD), "obsessive-compulsives" exhibited thought problems, low rates of comorbid CD, and high symptoms of inattention. "High psy…

Nutraceuticals and functional foods for the control of plasma cholesterol levels. An intersociety position paper

2018

Current evidence shows that cholesterol management either reduces the likelihood of cardiovascular disease (CVD) or slows down its progression. Hence, it is important that all health professionals make appropriate use of all the available intervention strategies to control risk factors: from dietary improvement and positive lifestyle changes to the use of functional foods, food supplements, and drugs. This review examines the effect of the most frequently occurring cholesterol-lowering substances in functional foods or in supplements across Europe, namely plant sterols and stanols, monacolin K found in red yeast rice, berberine and beta-glucans. We conclude that currently available suppleme…

2019

The objective of the present research was to investigate associations of dispositional and momentary self-control and the presence of other individuals consuming SSBs with the consumption frequency of sugar-sweetened beverages (SSBs) in a multi-country pilot study. We conducted an Ambulatory Assessment in which 75 university students (52 females) from four study sites carried smartphones and received prompts six times a day in their everyday environments to capture information regarding momentary self-control and the presence of other individuals consuming SSBs. Multilevel models revealed a statistically significant negative association between dispositional self-control and SSB consumption…

The Benefits of Believing in Chance or Fate: External Locus of Control as a Protective Factor for Coping with the Death of a Spouse

2010

The death of a spouse is an extremely stressful life event that consequently causes a large drop in life satisfaction. Reactivity to the loss, however, varies markedly, a phenomenon that is currently not well understood. Because lack of controllability essentially contributes to the stressful nature of this incident, the authors analyzed whether individual differences in belief in external control influence the coping process. To examine this issue, widowed individuals ( N = 414) from a large-scaled panel study were followed for the 4 years before and after the loss by using a latent growth model. Results showed that belief in external control led to a considerably smaller decline in life …

Internet-Based Intervention for Secondary and Tertiary Prevention of Depressive Symptoms

2016

Depression is one of the most disabling psychological disorders worldwide. A very important challenge today consists on addressing the issue of depression from a preventive perspective. A growing body of research supports the efficacy of Internet-based treatments. We have developed an Internet-based program (Smiling is Fun) with the objective of helping people in prevention of depression and anxiety symptoms. It is based on classical cognitive behavioral techniques, such as behavioural activation, and also includes other positive psychological strategies to improve coping ability and positive mood. We applied this intervention program in people who had to cope at least with one stressor in …

Anxiety and coping dispositions as predictors of the visual interaction between mother and child

1991

Abstract The “model of coping modes” distinguishes four dispositionally determined patterns of behavior (coping modes) which become apparent in stressful situations: repression, sensitization, nondefensiveness, and high anxiety. Following from this model, the present study is aimed at assessing associations between coping modes and children's looking behavior towards their mothers in a moderately stress-inducing laboratory setting. The visual exchange of 63 mothers and their eight- to 14-year-old children was observed during a ten-minute planning period for a Punch and Judy show which the child had to later perform. A close visual orientation toward the mother was registered for sensitizers…