Search results for "Primary and secondary"

Probing human beta1- and beta2 -adrenoceptors with domain-specific fusion protein antibodies.

1997

In order to generate antibodies suitable for immunological studies on beta-adrenoceptors constitutively expressed at low levels in cells or tissues we have produced fusion proteins of the amino- and carboxy-terminus, and the second extracellular loop of the human beta 1- or beta 2-adrenoceptors with bacterial glutathione-S-transferase in E. coli. Rabbit antibodies raised against these fusion proteins strongly reacted with intact human beta 1- or beta 2-adrenoceptors in a subtype- and domain-specific manner. Antibodies directed against the second extracellular loop of the beta 1-adrenoceptor reacted stronger with non-denatured receptors and decreased the affinity of the 3H-labelled antagonis…

Carnaval y música: una breve semblanza de la Tuna Compostelana de 1888

2021

At the end of the 19th century, Spanish carnivals have been marked by the participation of the different tunas or also known as, estudiantinas. These groups achieved significant relevance in Galicia, especially in the city of Compostela, which, year after year, encouraged and supported the formation of groups of this nature to liven up the carnivals in the different Spanish cities. Although, different from its predecessors, the Santiago Tuna of 1888 ventured and made its mark in history, thanks to its intrepidity in having been the first Galician group that crossed the borders and enlivened the carnivals in the cities of the neighboring country, Portugal. This research, approached from a hi…

Molecular mechanisms of primary and secondary mucosal immunity using avian infectious bronchitis virus as a model system

2007

Although mucosal immune responses are critical for protection of hosts from clinical illness and even mortality caused by mucosal pathogens, the molecular mechanism of mucosal immunity, which is independent of systemic immunity, remains elusive. To explore the mechanistic basis of mucosal protective immunity, gene transcriptional profiling in mucosal tissues was evaluated after the primary and secondary immunization of animals with an attenuated avian infectious bronchitis virus (IBV), a prototype of Coronavirus and a well-characterized mucosal pathogen. Results showed that a number of innate immune factors including toll-like receptors (TLRs), retinoic-acid-inducible gene-1 (RIG-1), type I…

Children's exploration of the concepts of home and belonging: Capturing views from five European countries.

2021

Understanding one's sense of belonging is a central part of identity formation and self-awareness; feeling safe somewhere, with specific people is identified as a basic human need. This paper explores the ideas of children from three age groups in five different European as they discussed the concepts of ‘home’ and ‘belonging’. Findings showed that the children's ideas could be organised into six interrelated aspects: Spatiality, Materiality, Multiplicity, Social Relations, Affect, and Dislocation. Whilst there were differences in the ways that the children conceptualised home across the classes, even the youngest children were able to describe their ideas using metaphors and abstract conce…

Progettazione, narrazione e analisi di pratiche didattiche di genere nel primo ciclo dell'istruzione

2017

The research contribution is part of the PRIN “Success training, inclusion and social cohesion: innovative strategies, ICT and valuation models”, coordinated by G. Domenici at national level, which ended on 28th February 2016. Within the Research unit of Palermo different assumptions have been made, including that of school failure in the first cycle which would be diminished if teachers had implemented a more careful teaching to different ways of learning of male and female pupils. Intervention refers to the process of construction, implementation, narration and analysis of thirty gender teaching practices. The first research goal has been that of producing and validating tools to provide …

Ankkalinna - portti kahden maailman välillä : Don Rosan Disney-sarjakuvat postmodernina fantasiana

2014

Impact of physical effort on von Willebrand factor’s activity and concentration in blood

2020

Background and Study Aim: Physical exercise causes a wide range of physiological changes including the production and release of haemostasis regulating factors. One of these factors is von Willebrand factor (vWf)- a glycoprotein responsible for both platelet adhesion and coagulation cascade. Material and Methods: The impact of physical effort on von Willebrand’s factor’s concentration (vWf:Ag) and activity (vWf:CBA) underwent analysis in the group of 42 people (22 men and 20 women) aged 19-22 (mean 20, SD 8 months). Physical effort was induced by 35 minutes of swimming in indoor swimming pool. Results: Physical exercise in form of swimming causes an increase of Willebrand’s factor’s concent…

The

2019

In actinomycetes, antibiotic production is often associated with a morpho-physiological differentiation program that is regulated by complex molecular and metabolic networks. Many aspects of these regulatory circuits have been already elucidated and many others still deserve further investigations. In this regard, the possible role of many small open reading frames (smORFs) in actinomycete morpho-physiological differentiation is still elusive. In Streptomyces coelicolor, inactivation of the smORF trpM (SCO2038) – whose product modulates L-tryptophan biosynthesis – impairs production of antibiotics and morphological differentiation. Indeed, it was demonstrated that TrpM is able to interact w…