Search results for "Probability distribution"
showing 10 items of 263 documents
Differential models of twin correlations in skew for body-mass index (BMI)
2018
Background Body Mass Index (BMI), like most human phenotypes, is substantially heritable. However, BMI is not normally distributed; the skew appears to be structural, and increases as a function of age. Moreover, twin correlations for BMI commonly violate the assumptions of the most common variety of the classical twin model, with the MZ twin correlation greater than twice the DZ correlation. This study aimed to decompose twin correlations for BMI using more general skew-t distributions. Methods Same sex MZ and DZ twin pairs (N = 7,086) from the community-based Washington State Twin Registry were included. We used latent profile analysis (LPA) to decompose twin correlations for BMI into mul…
Transforming RNA-Seq Data to Improve the Performance of Prognostic Gene Signatures
2014
Gene expression measurements have successfully been used for building prognostic signatures, i.e for identifying a short list of important genes that can predict patient outcome. Mostly microarray measurements have been considered, and there is little advice available for building multivariable risk prediction models from RNA-Seq data. We specifically consider penalized regression techniques, such as the lasso and componentwise boosting, which can simultaneously consider all measurements and provide both, multivariable regression models for prediction and automated variable selection. However, they might be affected by the typical skewness, mean-variance-dependency or extreme values of RNA-…
Assessment of Susceptibility Risk Factors for ADHD in Imaging Genetic Studies
2019
Objective: ADHD consists of a count of symptoms that often presents heterogeneity due to overdispersion and excess of zeros. Statistical inference is usually based on a dichotomous outcome that is underpowered. The main goal of this study was to determine a suited probability distribution to analyze ADHD symptoms in Imaging Genetic studies. Method: We used two independent population samples of children to evaluate the consistency of the standard probability distributions based on count data for describing ADHD symptoms. Results: We showed that the zero-inflated negative binomial (ZINB) distribution provided the best power for modeling ADHD symptoms. ZINB reveals a genetic variant, rs273342…
Joint Probability of Shape and Image Similarities to Retrieve 2D TRUS-MR Slice Correspondence for Prostate Biopsy
2012
International audience; This paper presents a novel method to identify the 2D axial Magnetic Resonance (MR) slice from a pre-acquired MR prostate volume that closely corresponds to the 2D axial Transrectal Ultrasound (TRUS) slice obtained during prostate biopsy. The method combines both shape and image intensity information. The segmented prostate contours in both the imaging modalities are described by shape-context representations and matched using the Chi-square distance. Normalized mutual information and correlation coefficient between the TRUS and MR slices are computed to find image similarities. Finally, the joint probability values comprising shape and image similarities are used in…
Interfacial tension of the isotropic-nematic interface in suspensions of soft spherocylinders.
2005
The isotropic to nematic transition in a system of soft spherocylinders is studied by means of grand canonical Monte Carlo simulations. The probability distribution of the particle density is used to determine the coexistence density of the isotropic and the nematic phases. The distributions are also used to compute the interfacial tension of the isotropic--nematic interface, including an analysis of finite size effects. Our results confirm that the Onsager limit is not recovered until for very large elongation, exceeding at least L/D=40, with L the spherocylinder length and D the diameter. For smaller elongation, we find that the interfacial tension increases with increasing L/D, in agreem…
SMAA - Stochastic multiobjective acceptability analysis
1998
Stochastic multiobjective acceptability analysis (SMAA) is a multicriteria decision support technique for multiple decision makers based on exploring the weight space. Inaccurate or uncertain input data can be represented as probability distributions. In SMAA the decision makers need not express their preferences explicitly or implicitly; instead the technique analyses what kind of valuations would make each alternative the preferred one. The method produces for each alternative an acceptability index measuring the variety of different valuations that support that alternative, a central weight vector representing the typical valuations resulting in that decision, and a confidence factor mea…
Prospect theory and stochastic multicriteria acceptability analysis (SMAA)
2009
Abstract We consider problems where multiple decision makers (DMs) want to choose their most preferred alternative from a finite set based on multiple criteria. Several approaches to support DMs in such problems have been suggested. Prospect theory has appealed to researchers through its descriptive power, but rare attempts have been made to apply it to support multicriteria decision making. The basic idea of prospect theory is that alternatives are evaluated by a difference function in terms of gains and losses with respect to a reference point. The function is suggested to be concave for gains and convex for losses and steeper for losses than for gains. Stochastic multicriteria acceptabil…
Limit Analysis of Structures with Stochastic Strength Variations∗
1972
Abstract On the basis of a probabilistic fomulation of the fundamental theorems of “limit analysis,” a procedure is developed which allows, with a very limited amount of computing work, the determination of a domain containing the probability distribution curve of the collapse load factor of any structure that satisfies the usual conditions for validity of the limit analysis, but has randomly distributed limit strengths. Further improvements of the bounds thus obtained can be achieved by the equivalent of either the equilibrium or the kinematic methods of limit analysis.
Solutions for districting problems with chance-constrained balancing requirements
2021
Abstract In this paper, a districting problem with stochastic demands is investigated. The goal is to divide a geographic area into p contiguous districts such that, with some given probability, the districts are balanced with respect to some given lower and upper thresholds. The problem is cast as a p -median problem with contiguity constraints that is further enhanced with chance-constrained balancing requirements. The total assignment cost of the territorial units to the representatives of the corresponding districts is used as a surrogate compactness measure to be optimized. Due to the tantalizing purpose of deriving a deterministic equivalent for the problem, a two-phase heuristic is d…
On the checking of g-coherence of conditional probability bounds
2003
We illustrate an approach to uncertain knowledge based on lower conditional probability bounds. We exploit the coherence principle of de Finetti and a related notion of generalized coherence (g-coherence), which is equivalent to the "avoiding uniform loss" property introduced by Walley for lower and upper probabilities. Based on the additive structure of random gains, we define suitable notions of non relevant gains and of basic sets of variables. Exploiting them, the linear systems in our algorithms can work with reduced sets of variables and/or constraints. In this paper, we illustrate the notions of non relevant gain and of basic set by examining several cases of imprecise assessments d…