Search results for "Process"
showing 10 items of 22310 documents
Comparison of RNA-seq and microarray-based models for clinical endpoint prediction
2015
Background Gene expression profiling is being widely applied in cancer research to identify biomarkers for clinical endpoint prediction. Since RNA-seq provides a powerful tool for transcriptome-based applications beyond the limitations of microarrays, we sought to systematically evaluate the performance of RNA-seq-based and microarray-based classifiers in this MAQC-III/SEQC study for clinical endpoint prediction using neuroblastoma as a model. Results We generate gene expression profiles from 498 primary neuroblastomas using both RNA-seq and 44 k microarrays. Characterization of the neuroblastoma transcriptome by RNA-seq reveals that more than 48,000 genes and 200,000 transcripts are being …
Transthoracic three-dimensional echocardiographic volumetry of distorted left ventricles using rotational scanning
1997
The purpose of this study was to evaluate the relation of transthoracic three- and two-dimensional echocardiographic left ventricular volumetry to cineventriculographic volumetry. Twenty-five patients with distorted left ventricles were included in the study. To demonstrate the impact of acquiring data by rotational scanning, we performed three- and two-dimensional echocardiography in 36 latex ventricles with data acquisition in different areas of the ultrasound sectors. Interobserver and intraobserver variability were calculated to test for reproducibility. The three-dimensional imaging system consisted of a rotation motor device, a transthoracic 2.5 MHz transducer, a conventional ultrasou…
The calculation of the first positive Lyapunov exponent in sleep EEG data
1993
To help determine if the EEG is quasiperiodic or chaotic we performed a new analysis by calculating the first positive Lyapunov exponent L1 from sleep EEG data. Lyapunov exponents measure the mean exponential expansion or contraction of a flow in phase space. L1 is zero for periodic as well as quasiperiodic processes, but positive in case of chaotic processes expressing the sensitive dependence on initial conditions. We calculated L1 for sleep EEG segments of 15 healthy male subjects corresponding to sleep stages I, II, III, IV and REM (according to Rechtschaffen and Kales). Our investigations support the assumption that EEG signals are neither quasiperiodic waves nor simple noise. Moreover…
Functional connectivity analysis using whole brain and regional network metrics in MS patients
2016
In the present study we investigated brain network connectivity differences between patients with relapsing-remitting multiple sclerosis (RRMS) and healthy controls (HC) as derived from functional resonance magnetic imaging (fMRI) using graph theory. Resting state fMRI data of 18 RRMS patients (12 female, mean age ± SD: 42 ± 12.06 years) and 25 HC (8 female, 29.2 ± 5.38 years) were analyzed. In order to obtain information of differences in entire brain network, we focused on both, local and global network connectivity parameters. And the regional connectivity differences were assessed using regional network parameters. RRMS patients presented a significant increase of modularity in comparis…
Changes in anatomic position of root canal orifices in pluriradicular teeth following re-location during endodontic treatment
2017
Abstract Direct access to the root canals in posterior teeth for endodontic treatment is most frequently facilitated by the straightening of the coronal parts of the root canals, having as a consequence the relocation of the canal orifices on the map of the floor of the pulp chamber ( Christie and Thompson, 1994 ). This procedure intentionally moves the coronal aspect of a canal away from the center of the chamber, while simultaneously removing internal dentin from the pulp chamber walls. The aim of this study was to evaluate the displacement resulting from the relocation of root canal orifices during the initial phase of rotary root canal treatment in molars using the dental operating micr…
Visual inference of arm movement is constrained by motor representations
2015
International audience; Several studies support the idea that motion inference is strongly motor dependent. In the present study, we address the role of biomechanical constraints in motion prediction and how this implicit knowledge can interfere in a spatial prediction task. Right-handed (RHS) and left-handed subjects (LHS) had to estimate the final position of a horizontal arm movement in which the final part of the trajectory was hidden. Our study highlighted a direction effect: end point prediction accuracy was better to infer the final position of horizontal motion directed toward the median line of human body. This finding suggests that the spatial prediction of end point is mapped ont…
Discovering dynamic task-modulated functional networks with specific spectral modes using MEG.
2019
Efficient neuronal communication between brain regions through oscillatory synchronization at certain frequencies is necessary for cognition. Such synchronized networks are transient and dynamic, established on the timescale of milliseconds in order to support ongoing cognitive operations. However, few studies characterizing dynamic electrophysiological brain networks have simultaneously accounted for temporal non-stationarity, spectral structure, and spatial properties. Here, we propose an analysis framework for characterizing the large-scale phase-coupling network dynamics during task performance using magnetoencephalography (MEG). We exploit the high spatiotemporal resolution of MEG to m…
Performance, balance and posture variations with Occlusal Splint and Taopatch® devices: a retrospettive cross-over study
2021
Background The aim of the study was to evaluate how muscular performances, balance and posture were influenced applying Occlusal Splints and Taopatch® 8 (Tao Technologies Srls, Cittadella, Padua, Italy) devices in athletes. Methods Eighteen athletes, 7 females and 11 males, with an average age of 23.8 years, were included. Two devices were used: 1) a customized soft occlusal splint to be applied to the lower ach; 2) nanotechnological devices based on carbon nanotubules and quantum dots (Taopatch®) positioned on C7 and xiphoid process. Four functional tests were performed: surface electromyography (sEMG), kinesiography, the squat jump and counter movement jump and handgrip test. The tests we…
Cognitive processess and cognitive reserve in multiple sclerosis
2015
Multiple Sclerosis (MS) is characterized by motor, cognitive, and neuropsychiatric symptoms, which can occur independently. While MS is traditionally considered an inflammatory disease of the white matter, degeneration of gray matter is increasingly recognized as an important contributor to the progressive cognitive decline. A protective factor against the progression of cognitive dysfunction in MS could be the cognitive reserve, defined as resistance to brain dysfunction. Aim of the present study is to evaluate the role of cognitive reserve for different aspects of cognitive dysfunction of patients with MS. We found that patients with MS and lower cognitive reserve have poorer neuropsychol…
Memory detection using fMRI - does the encoding context matter?
2015
Recent research revealed that the presentation of crime related details during the Concealed Information Test (CIT) reliably activates a network of bilateral inferior frontal, right medial frontal and right temporal-parietal brain regions. However, the ecological validity of these findings as well as the influence of the encoding context are still unclear. To tackle these questions, three different groups of subjects participated in the current study. Two groups of guilty subjects encoded critical details either only by planning (guilty intention group) or by really enacting (guilty action group) a complex, realistic mock crime. In addition, a group of informed innocent subjects encoded hal…