Search results for "Prodi"

Physiology and genetics of antibiotic production and resistance.

1993

Actinomycetes have the genetic capability to synthesize many different biologically active secondary metabolites and of these compounds, antibiotics predominate in therapeutic and commercial importance. Intensive research often centres on the use of molecular techniques to investigate the physiology and genetics of antibiotic biosynthesis with a view to improving production. The isolation of clones of Streptomyces hygroscopicus, the producer of geldanamycin, which synthesizes geldanamycin in S. lividans, is reported. Molecular approaches using genes for elongation factors (tuf) were used in attempts to increase the fermentation yield of kirromycin, whilst probes for aphD and sph, genes for …

Wicked behavior and catastrophes in the Roman world: believes, religiosity and politic

2014

La religión es un componente tan esencial en las sociedades del Mundo Antiguo que de su correcta difusión y de la perfecta realización de los cultos depende la disposición de los dioses y, con ella, el devenir de los acontecimientos. En la vida práctica, esto se transmite en dos ámbitos: la élite, el grupo encargado de la celebración de los ritos no puede cometer errores en su tarea; y el pueblo, todos los habitantes del territorio tienen que adherirse a la religión “estatal”. Cuando en alguno de estos dos elementos se producen fallos, se suceden prodigios y catástrofes de cualquier tipo. Frente a esto, la solución consiste en: castigo del causante o causantes de la impiedad y reparación de…

The effects of glutamate receptor antagonists on cerebellar granule cell survival and development.

2007

N-Methyl-d-aspartate (NMDA) receptor stimulation promotes neuronal survival and differentiation under both in vitro and in vivo conditions. We studied the effects of various NMDA receptor antagonists acting at different NMDA receptor binding sites and non-NMDA receptor antagonists on the development and survival of cerebellar granule cell (CGC) culture. Only three of the drugs tested induced neurotoxicity-MK-801 (non-competitive NMDA channel blocking antagonist), ifenprodil (an antagonist of the NR2B site and polyamine site of the NMDA receptor) and L-701.324 (full antagonist at glycine site), while CGP-37849 (a competitive NMDA antagonist), (+)-HA-966 (a partial agonist of the glycine site…

The NMDA receptor complex: a promising target for novel antiepileptic strategies.

2001

Antiepileptic drugs (AEDs) cover a broad spectrum of pathological conditions ranging from seizures following congenital or acquired brain disorders to behavioural and psychiatric disorders and recently neuropathic pain. The need for novel antiepileptics raises from the expanding field of indications as well as from the fact, that special seizure types are refractory to common AEDs. In addition, many of the conventional antiepileptic drugs exhibit an unfavourable side-effect profile. Since there is growing evidence, that NMDA receptor activation might play a crucial role in epilepsy, NMDA receptor antagonists have become compounds of interest in preventing and treating seizures. This review …

Pathway-specificity in N-methyl-d-aspartate receptor-mediated synaptic inputs onto subplate neurons

2007

The subplate plays an important role in forming neuronal connections during early cortical development. We characterized by the use of whole-cell and cell-attached patch-clamp recordings in coronal brain slices from newborn mice (postnatal day [P] 0-3) the functional properties of two major pathways onto subplate neurons (SPn), the thalamocortical and the intra-subplate synaptic input. The two afferent pathways were stimulated extracellularly with bipolar electrodes placed in the thalamus and the subplate, respectively. Synaptically evoked and pharmacologically isolated N-methyl-d-aspartate receptor (NMDAR) -mediated responses with an onset latency of approximately 6 ms could be reliably re…

El ‘relato maravilloso’ como expresión mítica de la presencia o ausencia divina

2020

El relato maravilloso constituye un recurso eficaz que el mito proporciona a las sociedades antiguas para articular y dar explicación a la relación del hombre con la naturaleza y a la presencia o ausencia de la protección divina. The ‘wonderful story ’constitutes an effective resource that myth provides to ancient societies to articulate and explain man’s relationship with nature and the presence or absence of divine protection.

Water sorption isotherms of molecularly imprinted polymers. Relation between water binding and iprodione binding capacity

2017

International audience; Molecularly imprinted polymers are often used in aqueous medium in order to recognize specifically a target molecule. The molecular recognition is usually based on hydrogen bonding. In this case, water molecule presents a serious competition towards the target molecule. In this study, the water sorption by molecularly imprinted polymers was studied in aqueous medium. The molecularly imprinted polymers were specific for iprodione fungicide and were prepared using a 24 full factorial experimental design. They were synthesized using EGDMA or TRIM as crosslinker, methacrylamide or styrene as functional monomer and using bulk or precipitation polymerization. The water sor…

Gli approdi dei Migranti: Lampedusa come Ellis Island?

2015

Il volume raccoglie alcune relazioni presentate in occasione del ciclo di seminari Letture e riletture sulla Sicilia e sul Meridione, inserito nell'ambito del progetto di ricerca FFR dell'Università di Palermo, coordinato da Salvatore Costantino, dal titolo Genesi dei fenomeni e dei comportamenti mafiosi: istituzioni, società civile e modelli teorici in Sicilia tra Otto e Novecento.

Mauro Bonazzi, I Sofisti. Pensatori, 18. Roma: Carocci Editore, 2010. Pp. 183. ISBN 9788843055913

2011

Design d'un iprodione-MIP (molecularly imprinted polymer) : application à la pré-concentration des fongicides dans le vin

2014

The aim of this study was the synthesis of a MIP (molecularly imprinted polymer) specific for a fungicide that is found in the majority of the french wine: iprodione. The challenge for extracting iprodione from wine medium was that the hydoralcoholic solution is a dipolar solvent, whereas the interaction between the MIP and iprodione is based on dipolar interactions. The first extraction study of iprodione was made on a MIP synthesized by bulk polymerization using methacrylamide and ethylene glycol dimethacrylate (EGDMA). The MIP was found to be more efficient than the NIP (non-imprinted polymer) in hydroalcoholic solutions which demonstrates that the molecular imprinting was successful. Th…