Search results for "Production"

Lipid Delivery Systems for Nucleic-Acid-Based-Drugs: From Production to Clinical Applications

2019

In the last years the rapid development of Nucleic Acid Based Drugs (NABDs) to be used in gene therapy has had a great impact in the medical field, holding enormous promise, becoming “the latest generation medicine” with the first ever siRNA-lipid based formulation approved by the United States Food and Drug Administration (FDA) for human use, and currently on the market under the trade name Onpattro™. The growth of such powerful biologic therapeutics has gone hand in hand with the progress in delivery systems technology, which is absolutely required to improve their safety and effectiveness. Lipid carrier systems, particularly liposomes, have been proven to be the most su…

Accounting for littoral primary production by periphyton shifts a highly humic boreal lake towards net autotrophy

2016

1. The prevailing view that many humic lakes are net heterotrophic is commonly based on pelagicmeasurements alone. Poor light conditions in humic lakes are assumed to constrain littoral primaryproduction (PP), such that the littoral zone has been considered an insignificant contributor towhole-lake PP. However, that assumption is based on models and inferences from pelagic processeswhich do not take littoral zone structure into account. Many lakes have an extensive ring of aquaticvegetation lying near the water surface, which provides substratum for epiphytic algae under well-illuminated conditions.2. We measured both pelagic and littoral PP and community respiration (CR) in Mekkoj€arvi, a s…

Biogenic Fenton process - A possible mechanism for the mineralization of organic carbon in fresh waters.

2020

To explore the mechanisms that mineralize poorly bioavailable natural organic carbon (OC), we measured the mineralization of OC in two lake waters over long-term experiments (up to 623 days) at different pH and iron (Fe) levels. Both the microbial and photochemical mineralization of OC was higher at pH acidified to 4 than at the ambient pH 5 or an elevated pH 6. During 244 days, microbes mineralized up to 60% of OC in the 10-mu m filtrates of lake water and more than 27% in the 1-mu m filtrates indicating that large-sized microbes/grazers enhance the mineralization of OC. A reactivity continuum model indicated that the acidification stimulated the microbial mineralization of OC especially i…

DISCRIMINATIONS ETHNIQUES DANS L’ACCES AU LOGEMENT: UNE EXPERIMENTATION EN NOUVELLE-CALEDONIE

2016

Dans cette étude, nous mesurons les discriminations dans l’accès au logement dans le GrandNouméa, selon l’origine ethnique, en distinguant les origines kanak et européennes, et selon lequartier de résidence. Entre octobre 2015 et février 2016, nous avons répondu à 342 annonces enprésentant 4 candidats à la location pour chaque annonce, soit 1368 réponses à des annoncesimmobilières. Deux de nos candidats signalent par leur patronyme leur origine kanak, deuxsignalent une origine européenne. Dans chaque paire, un candidat donne un signal de stabilitéfinancière et professionnelle en indiquant explicitement qu’il est fonctionnaire. L’étude consiste àexploiter statistiquement ces données en les c…

SYSTEMIC CONCEPT OF COMPANY’S LOGISTICS

2011

in all, currently operating enterprise in the market, both manufacturing and service sectors, there is a logistics system. The basic components of this system are the three main processes such as procurement, production and distribution. In this article we have presented and discussed in detail all of the above processes. In case of distribution were presented costs correlations incurred in connection with the distribution. When the production process is discussed methods for its improvement. And in the process of supply, emphasis is placed on the assessment of purchasers, the choice of location and price calculation.

Rosenbluth separation of the $\pi^0$ Electroproduction Cross Section off the Neutron

2017

We report the first longitudinal/transverse separation of the deeply virtual exclusive $\pi^0$ electroproduction cross section off the neutron and coherent deuteron. The corresponding four structure functions $d\sigma_L/dt$, $d\sigma_T/dt$, $d\sigma_{LT}/dt$ and $d\sigma_{TT}/dt$ are extracted as a function of the momentum transfer to the recoil system at $Q^2$=1.75 GeV$^2$ and $x_B$=0.36. The $ed \to ed\pi^0$ cross sections are found compatible with the small values expected from theoretical models. The $en \to en\pi^0$ cross sections show a dominance from the response to transversely polarized photons, and are in good agreement with calculations based on the transversity GPDs of the nucle…

Kulttuuripalveluista luovaan talouteen

2011

STATUS OF STRANGENESS ELECTRO-PRODUCTION AT MAMI

2009

At the Institut für Kernphysik in Mainz, Germany, the microtron MAMI has been upgraded to 1.5 GeV electron beam energy and can now be used to study strange hadronic systems. The magnetic spectrometer KAOS from GSI was dismantled and re-installed in the spectrometer facility operated by the A1 collaboration. The spectrometer's primary purpose is to study strangeness electro-production. Its compact design and its capability to detect negative and positive charged particles simultaneously under forward scattering angles complements the existing spectrometers. In 2008, an important milestone has been reached by the successful measurement of kaon production off a liquid hydrogen target. The ide…

Evoluzione dei materiali intelligenti

2015

L’attività progettuale presiede alla scelta dei materiali e alla capacità tecnica entro le due dimensioni dell’agire: le conoscenze precedenti e la tensione verso il futuro. Questo ha permesso di individuare la successione i paradigmi “tecnologico-materici” che si sono avvicendati, caratterizzando il progetto con la comparsa di nuovi materiali e processi produttivi. L’avvento dei compositi ha rimesso in discussione tutti i materiali stravolgendone le caratteristiche. The design activity governs the choice of materials and technical capacity within the two dimensions of action: the previous knowledge and the tension towards the future. This has allowed us to identify the succession of  "tech…

Isometric force-time parameters in monitoring of strength training : with special reference to acute responses to different loading resistances

2017

The aim of the present series of studies was to investigate acute neuromuscular responses to (1) different strength training loadings and using (2) different external resistances. In addition, chronic adaptations and dynamic performances were compared to (3) the changes in isometric force-time parameters at the group level, and to (4) the individual timing of the improvement in the rate of force development (RFD) due to hypertrophic or maximum strength followed by power strength training periods. The latter one was achieved by systematic, repeated monitoring. Sixty-nine physically active men (20-35 yrs), but not experienced in resistance training, took part in the present series of studies.…