Search results for "Profil"
showing 10 items of 2040 documents
Functional characterization of osteosarcoma cell lines provides representative models to study the human disease
2011
Cancer cell lines represent in vitro models for studying malignancies, general cell biology, drug discovery and more. Whether they can be considered as exact representative models of the parental tumors remains uncertain given the acquisition of additional ex vivo changes of the cells and the lack of tissue architecture and stroma. Previously, within the EuroBoNeT consortium, we characterized a collection of bone sarcoma cell lines on genomic and proteomic level. Here, we address the phenotypical and functional characterization of the unique set of osteosarcoma cell lines (n=19) in vitro and in vivo. For functional analysis of differentiation capacity, cells were stimulated towards osteobla…
Development of the first marmoset-specific DNA microarray (EUMAMA): a new genetic tool for large-scale expression profiling in a non-human primate
2007
Abstract Background The common marmoset monkey (Callithrix jacchus), a small non-endangered New World primate native to eastern Brazil, is becoming increasingly used as a non-human primate model in biomedical research, drug development and safety assessment. In contrast to the growing interest for the marmoset as an animal model, the molecular tools for genetic analysis are extremely limited. Results Here we report the development of the first marmoset-specific oligonucleotide microarray (EUMAMA) containing probe sets targeting 1541 different marmoset transcripts expressed in hippocampus. These 1541 transcripts represent a wide variety of different functional gene classes. Hybridisation of …
mRNA expression profiles of primary high-grade central osteosarcoma are preserved in cell lines and xenografts
2011
Abstract Background Conventional high-grade osteosarcoma is a primary malignant bone tumor, which is most prevalent in adolescence. Survival rates of osteosarcoma patients have not improved significantly in the last 25 years. Aiming to increase this survival rate, a variety of model systems are used to study osteosarcomagenesis and to test new therapeutic agents. Such model systems are typically generated from an osteosarcoma primary tumor, but undergo many changes due to culturing or interactions with a different host species, which may result in differences in gene expression between primary tumor cells, and tumor cells from the model system. We aimed to investigate whether gene expressio…
Nesīkšūnu plaušu vēža profils, diagnostika un ķirurģiskā ārstēšana pacientiem, kuri 2018. gadā tika pirmreizēji stacionēti Rīgas Austrumu klīniskās u…
2021
Šis pētījums ir daļa no liela “Nesīkšūnu plaušu vēža slimnieku dzīvildze Latvijā un Izaēlā (retrospektīva analīze): uz vērtībām balstītas veselības aprūpes izmantošanas būtiskie aspekti” pētījuma, kas tika veikts laika posmā no 2021.gada februāra līdz 2021.gada maijam. Šajā darbā savākti, apkopoti un statistiski apstrādāti dati par Rīgas Austrumu klīniskās universitātes slimnīcas “Tuberkulozes un plaušu slimību centrā” 2018.gada pirmreizēji stacionēto nesīkšūnu plaušu vēža pacientu profilu, audzēja raksturojumu, pielietoto diagnostiku un ķirurģisko ārstēšanu.
Renta de emergencia familiar en Gandia
2011
Sensible ante la situación económica y de nuevas necesidades emergentes, el Ayuntamiento de Gandia, como principal promotor de políticas sociales, considera necesario integrar dentro de sus iniciativas para promover la igualdad, la solidaridad y la mejora de la calidad de vida, un recurso económico para paliar las distintas situaciones en las que se encuentran familias sin ingresos debido a que los adultos integrantes de la unidad familiar se encuentran en situación de desempleo. Se impulsa, como respuesta a estas nuevas necesidades, una prestación de carácter periódico denominada Renta de Emergencia Familiar (REF) que viene acompañada de un conjunto de actuaciones de carácter municipal dir…
Nomina e responsabilità degli amministratori di societàin mano pubblica: note e profili distintivi dal regime generale.
2011
Innovations in Infant Feeding: Future Challenges and Opportunities in Obesity and Cardiometabolic Disease
2020
The field of nutrition in early life, as an effective tool to prevent and treat chronic diseases, has attracted a large amount of interest over recent years. The vital roles of food products and nutrients on the body’s molecular mechanisms have been demonstrated. The knowledge of the mechanisms and the possibility of controlling them via what we eat has opened up the field of precision nutrition, which aims to set dietary strategies in order to improve health with the greatest effectiveness. However, this objective is achieved only if the genetic profile of individuals and their living conditions are also considered. The relevance of this topic is strengthened considering the importance of …
Intermittent Fasting and the Possible Benefits in Obesity, Diabetes, and Multiple Sclerosis: A Systematic Review of Randomized Clinical Trials
2021
Intermittent fasting has become popular in recent years and is controversially presented as a possible therapeutic adjunct. A bibliographic review of the literature on intermittent fasting and obesity, diabetes, and multiple sclerosis was carried out. The scientific quality of the methodology and the results obtained were evaluated in pairs. Intermittent fasting has beneficial effects on the lipid profile, and it is associated with weight loss and a modification of the distribution of abdominal fat in people with obesity and type 2 diabetes as well as an improvement in the control of glycemic levels. In patients with multiple sclerosis, the data available are too scarce to draw any firm con…
Analisi per Ateneo. L’Università degli studi di Palermo
2013
Profilaxis antibiótica en odontología infantil: puesta al día
2006
La mayoría de las infecciones orofaciales tienen un origen odontogénico, son autolimitantes y drenan espontáneamente. Las bacterias que causan estas infecciones son generalmente saprofitas. Además los procedimientos odontológicos invasivos dan lugar a una bacteriemia transitoria. Cuando una lesión oral se contamina por una bacteria extrínseca deben administrarse la pauta antibiótica indicada, tan pronto como sea posible. En caso de pulpitis no suele estar indicado si la infección alcanza sólo al tejido pulpar o los tejidos inmediatamente adyacentes. En caso de dientes avulsionados, se aplicará antibiótico local junto con la administración de antibióticos sistémicos. El profesional debe cono…