Search results for "Prognostic"

Facteurs épidémiologiques influençant la survie dans le lymphome à cellules du manteau

2017

Mantle Cell Lymphoma (MCL) is a recently defined entity, typically characterised by the genetic translocation t(11 ;14)(q13 ;q32) and counting for 2 - 10% of all non-Hodgkin Lymphomas. With a median survival between 3 and 5 years after diagnosis, MCL is an agressive disease and despite the recent therapeutic advances little in know about its prognostic factors. Some studies had investigated clinicopathological features and new treatment strategies, but there is a lack of knowledge regarding the impact of lifestyle and environnemental factors on outcome of MCL patients. From 2008 to 2012, the LYSA Group conducted in France two prospective multi center clinical trials on MCL : LM manteau 2010…

Prognosis of resected intrahepatic cholangiocarcinoma

2017

Introduction. Complete resection stands as the only curative option for intrahepatic cholangiocarcinoma (IHCC). Still, prognosis remains poor after resection due to a recurrence rate over 60% leading to actual 5-year survival rates below 20%. Reliable prognostic estimation and better understanding of tumor biology would be of interest for improving IHCC prognosis.Methods. Using clinical and biological data from two large cohort of resected IHCC (MSKCC, n=189 and AFC, n=522), three objectives have been explored. First, assessing the performances of different published prognostic models. Second, defining the reliability of preoperative prognostic estimation using imaging, tumoral genomic prof…

An integrated modelling and remote sensing approach for hydrological study in arid and semi-arid regions: the SUDMED Program

2008

International audience; Recent efforts have been concentrated in the development of models to understand and predict the impact of environmental changes on hydrological cycle and water resources in arid and semi-arid regions. In this context, remote sensing data have been widely used to initialize, to force, or to control the simulations of these models. However, for several reasons, including the difficulty in establishing relationships between observational and model variables, the potential offered by satellite data has not been fully used. As a matter of fact, a few hydrological studies that use remote sensing data emanating from different sources (sensors, platforms) have been performe…

The unsolved question of acute pancreatitis. prognostic criteria: A case report

2014

Optimizing the Choice for Adjuvant Chemotherapy in Gastric Cancer.

2022

Advances in the management of gastric cancer have improved patient survival in the last decade. Nonetheless, the number of patients relapsing and dying after a diagnosis of localized gastric cancer is still too high, even in early stages (10% in stage I). Adjuvant systemic chemotherapy has been proven to significantly improve outcomes. In the present article we have critically reviewed the clinical trials that guide the current clinical practice in the adjuvant treatment of patients affected by resectable gastric cancer, focusing on the different approaches worldwide, i.e., adjuvant chemotherapy, adjuvant chemoradiotherapy, and perioperative chemotherapy. We also delineate the clinical–path…

Artificial Intelligence in Monitoring and Diagnostics of Electrical Energy Conversion Systems

2020

Diagnostics and prognostics of electrical energy conversion systems are moving forward with the rapid development of IT and artificial intelligence possibilities. This also broadens the horizons for classical and advanced condition and operation monitoring techniques, resulting in more accurate fault detection, degradation prognosis and calculation of remaining life of energy conversion systems, utilized in every aspect and field of industry today. This paper gives an overview of the necessity for condition monitoring and diagnostics of the mentioned systems, explaining the classical and advanced techniques for diagnostics. Methodology to diagnose and prognose the energy conversion units, w…

Registro quinquennale dell’attività di un singolo centro in TC Coronarica: appropriatezza clinica e considerazioni prognostiche

2012

Prevalenza e valore prognostico a 2 anni delle placche aterosclerotiche coronariche in 123 pazienti sottoposti ad Angiografia Coronarica mediante Tom…

2010

Prognostic Impact of let-7e MicroRNA and Its Target Genes in Localized High-Risk Intestinal GIST: A Spanish Group for Research on Sarcoma (GEIS) Study

2020

MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level, and they have been described as being associated with tumor prognosis. Here, miRNA profiling was planned to explore new molecular prognostic biomarkers in localized intestinal high-risk GIST. Paraffin tumor blocks of 14 and 86 patients were used in the discovery and expansion sets, respectively. GeneChip miRNA v3.0 was employed to identify the miRNAs differentially expressed between relapsed and non-relapsed patient samples, which were validated in the expansion set, by qRT-PCR. RT2 Profiler PCR Array was used for the screening of let-7e targets. Expression levels were co…

Multidimensional prognostic index and the risk of fractures: an 8-year longitudinal cohort study in the Osteoarthritis Initiative

2021

Abstract Summary In this longitudinal study, with a follow-up of 8 years, multidimensional prognostic index (MPI), a product of the comprehensive geriatric assessment, significantly predicted the onset of fractures in older people affected by knee osteoarthritis. Purpose Frailty may be associated with higher fracture risk, but limited research has been carried out using a multidimensional approach to frailty assessment and diagnosis. The present research aimed to investigate whether the MPI, based on comprehensive geriatric assessment (CGA), is associated with the risk of fractures in the Osteoarthritis Initiative (OAI) study. Methods Community-dwellers affected by knee OA or at high risk f…