Search results for "Programming"

Association between previously identified disease loci at Chr 21q22 and MHC and UC in Italian population.

2009

Human blastocysts derived from monopronuclear zygotes: a biological model for the study of ploidy, euploidy, topography and heteroparental inheritance

2019

Rapid evolving RNA gene HAR1A and schizophrenia

2008

SEQPACKER: A Biologist-Friendly User Interface to Manipulate Nucleotide Sequences in Genomic Epidemiology

2004

The aim of this paper is to present a new integrated bioinformatics tool for manipulating nucleotide sequences with a user-friendly graphical interface. This tool is named “SeqPacker” because it uses DNA/RNA sequences. In addition, SeqPacker can be seen as a kind of nucleotide chain editor using standardized technologies, nucleotide representation standards, and high platform portability in support of research in Genomic Epidemiology. SeqPacker is written in JAVA as free and stand-alone software for several computer platforms.

Methylation Dynamics in the Early Mammalian Embryo: Implications of Genome Reprogramming Defects for Development

2006

In mouse and most other mammalian species, the paternal and maternal genomes undergo parent-specific epigenetic reprogramming during preimplantation development. The paternal genome is actively demethylated within a few hours after fertilization in the mouse, rat, pig, bovine, and human zygote, whereas the maternal genome is passively demethylated by a replication-dependent mechanism after the two-cell embryo stage. These genome-wide demethylation waves may have a role in reprogramming of the genetically inactive sperm and egg chromatin for somatic development. Disturbances in this highly coordinated process may contribute to developmental failures and defects inmammals. The frequency and s…

Molecular and Cellular Insights into the Development of Uterine Fibroids

2021

Uterine leiomyomas represent the most common benign gynecologic tumor. These hormone-dependent smooth-muscle formations occur with an estimated prevalence of ~70% among women of reproductive age and cause symptoms including pain, abnormal uterine bleeding, infertility, and recurrent abortion. Despite the prevalence and public health impact of uterine leiomyomas, available treatments remain limited. Among the potential causes of leiomyomas, early hormonal exposure during periods of development may result in developmental reprogramming via epigenetic changes that persist in adulthood, leading to disease onset or progression. Recent developments in unbiased high-throughput sequencing technolog…

Developing the "next generation" of genetic association databases for complex diseases

2012

Tens of thousands of genetic association studies investigating the influence of common polymorphisms on disease susceptibility have been published to date. These include similar to 1,000 genome-wide association studies (GWAS). This vast amount of data in the field of complex genetics is becoming increasingly difficult to follow and interpret. It can be expected that the situation will become even more complex with the advent of association projects using next-generation technologies. One of the aims of the Human Variome Project is to concatenate such data in meaningful ways, for example, within the context of publicly available field synopses. Here, we present various examples of online gen…

Summaries of presentations during the sixth Workshop of the International Association of Phytoplankton Ecology and Taxonomy, Mondsee, Austria, 15–25 …

1987

Le diatomee bentoniche del porto di Palermo

1979

Abstract Benthic diatoms in the harbour of Palermo (Sicily).—The first results of a systematic investigation on the benthic diatoms on the fouling settlements, at four selected sites in the harbour of Palermo, are reported. Samples of comparable areas have been examined either on the fouling of vertical walls of the wharfs or on asbestos panels vertically submerged at the same place for at least eighteen months. Seventy-seven species have been found. No marked taxonomic difference is evident between the populations on the stoneworks and those on the panels.

From the Harbour to the City. The Process of Urban Renewal in Trapani

2016

The chapter describes the study case of Trapani historical watwerfront, in particular the design solution adopted for nautical sport events and linked to regional landscape quality. The Trapani fluidity is connetted with an entrenched sea cultural and natural heritage. Actions, plans and programmes implemented for regeneration and development are based on cultural and natural heritage to be regulated, connected and transformed, in order to preserve the urban and regional identity.