Search results for "Progression"
showing 10 items of 1251 documents
Periodontitis and alzheimer´s disease
2020
Background Alzheimer's disease (AD), the main cause of dementia in the adult population, is characterized by a progressive loss of cognitive function. It is considered that neuroinflammation plays a fundamental role in its onset and progression. The bacteria present in the disbiotic microbiome generated during the course of periodontitis (PE) are capable of inducing a systemic inflammatory response, exacerbating the production of proinflammatory mediators that have the potential to spread to the systemic circulation. Material and Methods A literature review was made using the databases Scielo, PubMed, EBSCO and key words "Alzheimer disease", "Periodontitis", "Neurodegeneration", "Inflammati…
Concorsi interni e riparto di giurisdizione
2003
Il contributo analizza il problematico inquadramento sistematico dei concorsi riservati al personale interno per gli avanzamenti di carriera (progressioni verticali), con particolare riferimento alla tutela giurisdizionale, se riservata al giudice amministrativo ovvero, in linea con il processo di privatizzazione del pubblico impiego, al giudice ordinario.
Physical activity as a protective factor for dementia and Alzheimer’s disease: systematic review, meta-analysis and quality assessment of cohort and …
2022
ObjectivePhysical activity (PA) is associated with a decreased incidence of dementia, but much of the evidence comes from short follow-ups prone to reverse causation. This meta-analysis investigates the effect of study length on the association.DesignA systematic review and meta-analysis. Pooled effect sizes, dose–response analysis and funnel plots were used to synthesise the results.Data sourcesCINAHL (last search 19 October 2021), PsycInfo, Scopus, PubMed, Web of Science (21 October 2021) and SPORTDiscus (26 October 2021).Eligibility criteriaStudies of adults with a prospective follow-up of at least 1 year, a valid cognitive measure or cohort in mid-life at baseline and an estimate of the…
Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters
2002
In the present study, we addressed the question of a putative relevance of Rho proteins in tumour progression by analysing their expression on protein and mRNA level in breast tumours. We show that the level of RhoA, RhoB, Rac1 and Cdc42 protein is largely enhanced in all tumour samples analysed (n=15) as compared to normal tissues originating from the same individual. The same is true for 32P-ADP-ribosylation of Rho proteins which is catalysed by Clostridium botulinum exoenzyme C3. Also the amount of Rho-GDI and ERK2 as well as the level of overall 32P-GTP binding acvitity was tumour-specific elevated, yet to a lower extent than Rho proteins. Although the amount of Rho proteins was enhance…
Rho GTPases: Promising Cellular Targets for Novel Anticancer Drugs
2006
Ras-homologous (Rho) GTPases play a pivotal role in the regulation of numerous cellular functions associated with malignant transformation and metastasis. Rho GTPases are localized at membranes and become activated upon stimulation of cell surface receptors. In their GTP-bound (=active) state, Rho proteins bind to effector proteins, thereby triggering specific cellular responses. Members of the Rho family of small GTPases are key regulators of actin reorganization, cell motility, cell-cell and cell-extracellular matrix (ECM) adhesion as well as of cell cycle progression, gene expression and apoptosis. Each of these functions is of importance for the development and progression of cancer. Fu…
Open-ended projects opened up — aspects of openness
2017
Abstract—One of the most important areas of competence for professional engineers is the ability to function well in project work, in particular they need to be able to efficiently solve open-ended problems in different collaborative settings. The development of this ability is however not prominent in engineering education despite numerous authors suggesting openended problems as a pedagogical tool to promote development of collaborative problem solving competence by including elements of group or project work in courses. In our own long experience of using open-ended problems in collaborative student projects, we have identified a lack of systematic progression in learning outcomes and sk…
Translingual quoting in journalism : behind the scenes of Swiss television newsrooms
2019
This chapter focuses on translingual quoting (TQ), i.e. the subprocess of news-writing by which utterances from sources are both quoted and translated. Analyses of journalists’ mental and material activities suggest conceptualizing TQ as a complex and dynamic activity in which journalists’ individual and collective (e.g., institutional) language awareness, knowledge, and practices interact with multi-layered contexts of text production. Based on this empirically and theoretically grounded concept of TQ, the chapter presents a two-part typology of TQ: In sequential TQ, ready-made media items or interview materials are translated into another language; in parallel TQ, interviews and/or texts …
Moderno approccio alla trombosi venosa superficiale
2010
IMI Prevention of Myopia and Its Progression
2021
The prevalence of myopia has markedly increased in East and Southeast Asia, and pathologic consequences of myopia, including myopic maculopathy and high myopia-associated optic neuropathy, are now some of the most common causes of irreversible blindness. Hence, strategies are warranted to reduce the prevalence of myopia and the progression to high myopia because this is the main modifiable risk factor for pathologic myopia. On the basis of published population-based and interventional studies, an important strategy to reduce the development of myopia is encouraging schoolchildren to spend more time outdoors. As compared with other measures, spending more time outdoors is the safest strategy…
Virskorekcijas pielietojamība tuvredzības progresijas novērtēšanā ortokeratoloģijas pacientiem
2022
Darbs ir uzrakstīts angļu valodā uz 93 lapaspusēm. Tas satur 49 attēlus, 24 tabulas un 95 atsauces uz literatūras avotiem. Šī darba mērķis ir pārbaudīt, vai virskorekcija ir derīga metode tuvredzības progresēšanas novērtēšanai ortokeratoloģijā. Hipotēze ir atrast lielākas izmaiņas gados jaunākiem pacientiem nekā pieaugušajiem, kā tas ir norādīts literatūrā. Pētījumā iekļauti 192 Eiropeīdās rases subjekti vecumā no 6 līdz 56 gadiem (vidēji 19,61±10,30). Izmantojot retrospektīvu analīzi, no objektīva BOZR kontaktlēcas parametra tiek iegūta virskorekcija (ORX). Jaunākiem cilvēkiem ir lielākas ORX vērtības, bet pieaugušajiem nav atšķirības (p<0,05). Vidēji tuvredzība progresēja par –0,18±0,44 D…