Search results for "Proliferation"
showing 3 items of 1193 documents
Synthesis, antiproliferative activity, and in silico insights of new 3-benzoylamino-benzo[ b ]thiophene derivatives
2014
A new series of 3-benzoylamino-5-imidazol-5-yl-benzo[b]thiophenes and the parent amino derivatives were synthesized and screened as antitumor agents. All tested compounds showed concentration-dependent antiproliferative activity profile against HeLa cell line, exhibiting GI50 values in the low micromolar range. The most active compounds were tested in cell cycle perturbation experiments. A rapid accumulation of cells in the G2/M phase, with a concomitant reduction of cells in both the S and G0/G1 phases, was observed, suggesting that cell exposure to selected derivatives produces mitotic failure. To rationalize the biological results, the 3-benzoylamino-benzo[b]thiophenes were analyzed thro…
Kodolieroču neizplatīšanas uzraudzības un pārbaudes mehānismi: Irānas (2002 – 2015) gadījuma analīze
2020
Maģistra darbs “Kodolieroču neizplatīšanas uzraudzības un pārbaudes mehānismi: Irānas (2002 – 2015) gadījuma analīze” analizē Irānas kodolprogrammas uzraudzību laika posmā no 2002. līdz 2015. gadam. Pētījuma mērķis ir noskaidrot, kāpēc Irānas kodolprogrammas statuss tiek regulāri apšaubīts. Darba teorētisko ietvaru veido kodolieroču neizplatīšanas režīma galveno komponentu analīze. Šī gadījuma analīzē tiek izmantotas kvalitatīvās pētniecības metodes – oficiālo ziņojumu, dokumentu un līgumu kontentanalīze, kā arī tiek veikta akadēmisko pētījumu izpēte. Pētījuma rezultātā tiek izdarīti secinājumi, kā iesaistītās puses kodolieroču neizplatīšanas uzraudzības un pārbaudes ietvaros reaģē uz tām s…
CVB3 VP1 interacts with MAT1 to inhibit cell proliferation by interfering with Cdk-activating kinase complex activity in CVB3-induced acute pancreati…
2021
Coxsackievirus B3 (CVB3) belongs to the genus Enterovirus of the family Picornaviridae and can cause acute acinar pancreatitis in adults. However, the molecular mechanisms of pathogenesis underlying CVB3-induced acute pancreatitis have remained unclear. In this study, we discovered that CVB3 capsid protein VP1 inhibited pancreatic cell proliferation and exerted strong cytopathic effects on HPAC cells. Through yeast two-hybrid, co-immunoprecipitation, and confocal microscopy, we show that Menage a trois 1 (MAT1), a subunit of the Cdk-Activating Kinase (CAK) complex involved in cell proliferation and transcription, is a novel interaction protein with CVB3 VP1. Moreover, CVB3 VP1 inhibited MAT…