Search results for "Proline"
showing 10 items of 183 documents
PHD3 regulates EGFR internalization and signalling in tumours
2014
Tumours exploit their hypoxic microenvironment to induce a more aggressive phenotype, while curtailing the growth-inhibitory effects of hypoxia through mechanisms that are poorly understood. The prolyl hydroxylase PHD3 is regulated by hypoxia and plays an important role in tumour progression. Here we identify PHD3 as a central regulator of epidermal growth factor receptor (EGFR) activity through the control of EGFR internalization to restrain tumour growth. PHD3 controls EGFR activity by acting as a scaffolding protein that associates with the endocytic adaptor Eps15 and promotes the internalization of EGFR. In consequence, loss of PHD3 in tumour cells suppresses EGFR internalization and hy…
Toward More Efficient Organocatalysts
2011
Determination of Pyrrole Derivatives and Hydroxyproline with 4-(Dimethylamino)benzaldehyde in a Micellar Medium
1994
Abstract The spectrophotometric determination of pyrrole derivatives and hydroxyproline with 4-(dimethylamino)benzaldehyde (Ehrlich's reagent) in a sodium dodecyl sulphate micellar medium is studied. Pyrrole and pyrrole-2-carboxylic acid were used as model compounds for the optimization of the procedure. In the micellar medium with 0.2 M HCl at 90° C, pyrrole reacts in 15 min, whereas a HCl concentration larger than 5 M is required in the absence of the surfactant. The sensitivity increases from 1.3 to 5.6-fold with respect to the use of a non-micellar medium, for some pyrrole derivatives. The procedure is applied to the determination of hydroxyproline in meat samples.
CCDC 178510: Experimental Crystal Structure Determination
2003
Related Article: B.Macias, M.V.Villa, E.Chicote, S.Martin-Velasco, A.Castineiras, J.Borras|2002|Polyhedron|21|1899|doi:10.1016/S0277-5387(02)01098-7
CCDC 627339: Experimental Crystal Structure Determination
2007
Related Article: C.Peifer, O.Werz, D.Poeckel, D.Schollmeyer, S.Laufer|2006|Acta Crystallogr.,Sect.E:Struct.Rep.Online|62|o5138|doi:10.1107/S1600536806042930
CCDC 1981551: Experimental Crystal Structure Determination
2021
Related Article: Amberley D. Stephens, Muhammad Nawaz Qaisrani, Michael T. Ruggiero, Gonzalo Díaz Mirón, Uriel N. Morzan, Mariano C. González Lebrero, Saul T. E. Jones, Emiliano Poli, Andrew D. Bond, Philippa J. Woodhams, Elyse M. Kleist, Luca Grisanti, Ralph Gebauer, J. Axel Zeitler, Dan Credgington, Ali Hassanali, Gabriele S. Kaminski Schierle|2021|Proc.Nat.Acad.Sci.USA|118|e2020389118|doi:10.1073/pnas.2020389118
CCDC 179596: Experimental Crystal Structure Determination
2004
Related Article: H.Jankovics, C.Pettinari, F.Marchetti, E.Kamu, L.Nagy, S.Troyanov, L.Pellerito|2003|J.Inorg.Biochem.|97|370|doi:10.1016/S0162-0134(03)00309-X
CCDC 641477: Experimental Crystal Structure Determination
2010
Related Article: U.Scholten, C.Diserens, H.Stoeckli-Evans, K.Bernauer, M.Meyer, L.Stuppfler, D.Lucas|2009|Inorg.Chem.|48|10942|doi:10.1021/ic900330q
(4R)-4-Hydroxy-1-[(2S)-2-hydroxydodecyl]-L-proline monohydrate
2006
The title compound, C17H33NO4·H2O, was found to be the S diastereoisomer with respect to the asymmetric C atom at the OH group on the chain. The X-ray structure was determined as part of a study of the molecular geometry and stereochemistry of l-proline derivatives for pre-coating thin-layer chromatography plates intended for enantiomeric separation.