Search results for "Prom"
showing 10 items of 2286 documents
Retinoids as a Perspective in Treatment of Alzheimer’s Disease
2010
<i>Background:</i> In the past, we demonstrated that the disintegrin metalloproteinase ADAM10 has α-secretase activity in vitro and in cultured cells. We also found out that moderate overexpression of this proteinase inhibits Aβ peptide production and prevents the formation of amyloid plaques in an Alzheimer’s disease (AD) mouse model. Moreover, it corrects early hippocampal defects like LTP impairment and increases cortical synaptogenesis. <i>Objective:</i> Upregulation of ADAM10 might be an alternative approach concerning AD therapy. Our current research therefore focuses on substances and/or pathways which regulate ADAM10 gene expression. <i>Methods:</i&g…
Effects of anti-miR-182 on TSP-1 expression in human colon cancer cells: there is a sense in antisense?
2013
Abstract: Objective: miRNAs are attractive molecules for cancer treatment, including colon rectal cancer (CRC). We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 (TSP-1) expression, a protein down-regulated in CRC and inversely correlated with tumor vascularity and metastasis. Background: MicroRNAs are small non-coding RNAs that regulate the expression of different genes, involved in cancer progression, angiogenesis and metastasis. miR-182, over-expressed in colorectal cancer (CRC), has like predictive target thrombospondin-1 (TSP-1), a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of…
Nuclear receptor NR5A2 and bone: gene expression and association with bone mineral density
2011
El pdf del artículo es el manuscrito de autor (PMCID: PMC3682472).-- et al.
Acute selective ablation of rat insulin promoter-expressing (RIP HER ) neurons defines their orexigenic nature
2012
Rat insulin promoter (RIP)-expressing neurons in the hypothalamus control body weight and energy homeostasis. However, genetic approaches to study the role of these neurons have been limited by the fact that RIP expression is predominantly found in pancreatic β-cells, which impedes selective targeting of neurons. To define the function of hypothalamic RIP-expressing neurons, we set out to acutely and selectively eliminate them via diphtheria toxin-mediated ablation. Therefore, the diphtheria toxin receptor transgene was specifically expressed upon RIP-specific Cre recombination using a RIP-Cre line first described by Herrera (RIP HER -Cre) [Herrera PL (2000) Development 127:2317–2322]. Usi…
Melatonin stimulates the nonamyloidogenic processing ofβAPP through the positive transcriptional regulation of ADAM10 and ADAM17
2014
Melatonin controls many physiological functions including regulation of the circadian rhythm and clearance of free radicals and neuroprotection. Importantly, melatonin levels strongly decrease as we age and patients with Alzheimer's disease (AD) display lower melatonin than age-matched controls. Several studies have reported that melatonin can reduce aggregation and toxicity of amyloid-β peptides that are produced from the β-amyloid precursor protein (βAPP). However, whether melatonin can directly regulate the βAPP-cleaving proteases ('secretases') has not been investigated so far. In this study, we establish that melatonin stimulates the α-secretase cleavage of βAPP in cultured neuronal an…
A New Mutation in the Promoter Region of the PAX8 Gene Causes True Congenital Hypothyroidism with Thyroid Hypoplasia in a Girl with Down's Syndrome
2014
Thyroid dysfunction is common in newborn infants with Down's syndrome (DS), but defects causing classic thyroid dysgenesis (TD) with permanent congenital hypothyroidism (CH) have not been described.We studied a girl with DS and CH who had a mutation in the promoter sequence of the PAX8 gene.A female infant was found to have trisomy 21 and CH, with a venous thyrotropin (TSH) of150 mU/L and a free thyroxine (fT4) of 15.1 pmol/L (day 12). Thyroid peroxidase antibodies and thyroglobulin antibodies were elevated. Scintigraphy showed normal uptake, but ultrasound identified a small gland with heterogenous echotexture and cystic changes. Sequence analysis of the PAX8 gene revealed a new heterozygo…
Classification of EEG signals for prediction of epileptic seizures
2022
Epilepsy is a common brain disorder that causes patients to face multiple seizures in a single day. Around 65 million people are affected by epilepsy worldwide. Patients with focal epilepsy can be treated with surgery, whereas generalized epileptic seizures can be managed with medications. It has been noted that in more than 30% of cases, these medications fail to control epileptic seizures, resulting in accidents and limiting the patient’s life. Predicting epileptic seizures in such patients prior to the commencement of an oncoming seizure is critical so that the seizure can be treated with preventive medicines before it occurs. Electroencephalogram (EEG) signals of patients recorded to ob…
Mapeo de activos en salud en dos barrios vulnerables y su dinamización en una intervención comunitaria participativa
2017
Título: Mapeo de activos en salud en dos barrios vulnerables y su dinamización en una intervención comunitaria participativa Resumen Objetivos: 1) Describir el proceso y resultados de elaboración de los mapas de activos para la salud de dos barrios en situación de elevada vulnerabilidad social en los que se lleva a cabo una intervención comunitaria participativa de promoción de salud 2) Describir el proceso y resultados de dinamizar el mapa de activos de cada uno de los barrios en una propuesta de intervención comunitaria en salud Metodología: Estudio descriptivo en el que se utilizaron entrevistas individuales y grupales y dinámicas participativas. Se realizó en los barrios El Raval de Alg…
Darba vide un nodarbināto veselības veicināšana dzērienu ražošanas uzņēmumos
2022
“Darba vide un nodarbināto veselības veicināšana dzērienu ražošanas uzņēmumos”. Darba autore: Elīna Januma Darba vadītāja: asoc. prof., Dr.med. Ženija Roja Darbs izklāstīts uz 90 lapas, ietver 26 attēlus, 5 tabulas, 40 literatūras avotus, 13 pielikumus. Latviešu valodā. Maģistra darba mērķis ir pētīt darba vidi un veselības veicināšanu dzērienu ražošanas uzņēmumos un izstrādāt veselības veicināšanas pasākumus dzērienu ražošanas uzņēmumiem. Darbs sastāv no 4 nodaļām. Pirmajā nodaļā veikta literatūras analīze. Nodaļā ietverts dzērienu ražošanas nozares un nozarei raksturīgāko risku apskats, veselības veicināšanas darbā pieredze Latvijā un citās pasaules valstīs. Saistībā ar nodarbināto veselī…