Search results for "Prom"
showing 10 items of 2286 documents
Rac1 and PAK1 are upstream of IKK-ε and TBK-1 in the viral activation of interferon regulatory factor-3
2004
The anti-viral type I interferon (IFN) response is initiated by the immediate induction of IFN beta, which is mainly controlled by the IFN-regulatory factor-3 (IRF-3). The signaling pathways mediating viral IRF-3 activation are only poorly defined. We show that the Rho GTPase Rac1 is activated upon virus infection and controls IRF-3 phosphorylation and activity. Inhibition of Rac1 leads to reduced IFN beta promoter activity and to enhanced virus production. As a downstream mediator of Rac signaling towards IRF-3, we have identified the kinase p21-activated kinase (PAK1). Furthermore, both Rac1 and PAK1 regulate the recently described IRF-3 activators, I kappa B kinase- and TANK-binding kina…
Encuentro de saberes: Huellas de memoria pluriversa y descolonización de la Universidad contemporánea
2018
This paper studies the Encounter of Knowledge as a project that, by welcoming mestres and mestras of ancestral knowledge into universities, contributes to decolonize higher education, broadening its field of memory. Based on a systematization exercise, we established a theoretical dialogue with Bajtin and Bejamin. Based on the participation of four mestres -Lucely Pío, raicera del Cerrado, Mãe Lu and Tata Mutá Imé, religious leaders of Candomblé and the political leader and shaman Álvaro Tukano of the Tukano nation- we show how the project promotes in the contemporary Brazilian university a space of mnemic pluriversity, capable of activating diverse narrative planes (biographical, political…
El redreçament nacionalista valencià des del setmanari valencianista - El Camí - (1932 - 1934)
2022
La Tesi doctoral: “El redreçament nacionalista valencià des del setmanari valencianista El Camí (1932-1934).” L’objectiu de la Tesi és la importància del setmanari valencianista en la història cultural contemporània del País Valencià, dins dels periòdics nacionalistes valencians del primer terç del segle XX. La Tesi s’articula en cinc capítols. En el primer capítol, s’analitzen les persones –col•laboradors- que escriuen en el setmanari, una mena de Dramatis Personae, per mostrar quins temes aborden, quin és el propòsit del setmanari i quins són els objectius dels seus editors, arran de la pluralitat d’opinions vessades en la revista En el primer capítol de la Tesi s’ha volgut analitzar quin…
Cultural Heritage of the Klodzko Region as a Tourism Product of the Sudetes Region
2013
Predicción del éxito y el rendimiento académico en estudiantes dominicanos de tercero de secundaria: Un modelo procesual de variables contextuales y …
2019
El estudio “Predicción del éxito y el rendimiento académico en estudiantes dominicanos de tercero de secundaria: Un modelo procesual de variables contextuales y personales”, se ha realizado con una muestra representativa de 1,712 estudiantes de los Distritos Educativos 03-04 y 11-01. Los objetivos del estudio son: a) determinar las características psicométricas de los cuestionarios del estudio; b) analizar cómo afectan al éxito y al rendimiento académico distintas variables contextuales: apoyo padres, compañeros y docentes, zona de residencia, sector educativo, calidad del centro, nivel estudio de padres, pertenencia a grupos juveniles, práctica deportiva, sexo y edad; c) analizar cómo afec…
Effects of Oral Supplementation with Myo-Inositol and D-Chiro-Inositol on Ovarian Functions in Female Long-Term Survivors of Lymphoma: Results from a…
2022
The progressive improvement of lymphoma treatment has led to an important prolongation of patient survival and life expectancy. The principal international scientific societies of oncology now therefore recommend that long-term survivors of lymphoma join fertility programs. Specifically, fertile-age patients should be assisted by a multidisciplinary team, including specialists dedicated to fertility preservation in oncology, in order to support the completion of their reproductive project. In the general population, the use of Myo-Inositol and D-Chiro-Inositol (MI/DCI) has been demonstrated to be an effective choice to treat ovarian dysfunctions, with a consequent improvement in reproductiv…
La responsabilidad en la participación: un valor cooperativo en la educación primaria
2014
El articulo pretende destacar los principios del movimiento cooperativo, sus valores formativos y su necesaria vigencia en la actualidad. Se apuesta por el fomento de la responsabilidad en la participacion en los diferentes cursos de educacion primaria a partir del despliegue de diversos ejes de trabajo. Se ofrece una propuesta teoricopractica de intervencion tomando la escuela como principal ambito de actuacion concretada en diversas actividades a desarrollar en cada uno de los ciclos de una escuela de Tarragona. Los resultados de la investigacion nos han puesto de manifiesto el interes, la reflexion y la sensibilidad del alumnado en temas relacionados con la responsabilidad en la particip…
El efecto moderador de la edad en la relación entre el valor percibido, las TIC del minorista y la lealtad del cliente
2010
AbstractInformation and communication technology (ICT) may represent a source of benefits for retailers. However, there is a debate in the literature on how ICT influences customer-supplier relationships. In addition, the evidence on the effect of age on consumer attitudes towards retail technological solutions is not conclusive. This paper proposes and tests a model to analyze the influence of retail ICT on consumer loyalty towards the retailer, as well as to assess the moderating role of consumer age on this relationship. As a result, customer assessment of retail ICT, together with perceived value, exerts a positive influence on consumer commitment and satisfaction, being the latter an a…
Inhibition of small G proteins of the Rho family by statins orClostridium difficiletoxin B enhances cytokine-mediated induction of NO synthase II
2000
In order to investigate the involvement of Ras and/or Rho proteins in the induction of the inducible isoform of nitric oxide synthase (NOS II) we used HMG-CoA reductase inhibitors (statins) and Clostridium difficile toxin B (TcdB) as pharmacological tools. Statins indirectly inhibit small G proteins by preventing their essential farnesylation (Ras) and/or geranylgeranylation (Rho). In contrast, TcdB is a glucosyltransferase and inactivates Rho-proteins directly. Human A549/8- and DLD-1 cells as well as murine 3T3 fibroblasts were preincubated for 18 h with statins (1–100 μM) or TcdB (0.01–10 ng ml−1). Then NOS II expression was induced by cytokines. NOS II mRNA was measured after 4–8 h by R…
Stiffness Estimation and Adaptive Control for Soft Robots
2022
Nonostante la sorprendente crescita nello sviluppo dei robot ispirati alla natura, tra cui i cosiddetti soft robot, il potenziale di questi sistemi, che hanno intrinseche capacità di adattamento, non è ancora stato sfruttato a pieno. La ricerca ha principalmente considerato il controllo in retroazione della posizione dei giunti del robot, lasciando la gestione della cedevolezza di questi ultimi ancora in anello aperto. Peraltro, le attuali limitazioni nel processo di produzione degli attuatori a cedevolezza variabile e l'inevitabile variabilità nel tempo degli elementi elastici costitutivi, i quali sono soggetti ad usura e deformazione plastica, rendono il problema della determinazione prec…