Search results for "Prostate"

LXR, prostate cancer and cholesterol: the Good, the Bad and the Ugly.

2012

International audience; Cholesterol is a fundamental molecule for life. Located in the cell membrane, this sterol participates to the cell signaling of growth factors. Inside the cell it can be converted in hormones such as androgens or modulate the immune response. Such important functions could not be solely dependent of external supply by diet hence de novo synthesis could occur from acetate in almost all mammalian cells. If a deficiency in cholesterol sourcing leads to development troubles, overstocking has been associated to various diseases such as atherosclerosis and cancers. Cholesterol homeostasis should thus be tightly regulated at the uptake, de novo synthesis, storage and export…

Hypofractionnated radiotherapy for elderly patients with prostate cancer

2018

Radiation therapy technique and schedules could be adapted to patient's age because of a natural history of prostate cancer perceived as different, taking into account the comorbidities of patients but also a particular tolerance of elderly subjects. Thus, in localized prostate cancer, evaluation of associated diseases is essential before considering a treatment that will be of interest only if the life expectancy is greater than 10 years. When a curative approach is decided, radiotherapy holds a place of choice. Due to the recent results of randomized studies evaluating moderate hypofractionnated radiotherapy, showing a carcinological equivalence compared to a standard fractionation, this …

Expertise sur les pesticides incluant le chlordécone en lien avec le cancer de la prostate en vue de la création d'un tableau de maladie professionne…

2021

Citation suggérée: Anses. (2021). Expertise sur les pesticides incluant le chlordécone en lien avec le cancer de la prostate en vue de la création d'un tableau de maladie professionnelle ou de recommandations aux comités régionaux de reconnaissance des maladies professionnelles (CRRMP). (Saisine 2018-SA-0267). Maisons-Alfort : Anses, 332 p; Le plan d’actions sur les produits phytopharmaceutiques publié en avril 2018 vise notamment, sur la base des recommandations formulées par l’Inspection générale des affaires sociales, l’Inspection générale des finances et le Conseil général de l’alimentation, de l’agriculture et des espaces ruraux dans leur rapport conjoint de janvier 2018, à améliorer l…

Plasma levels of angiogenetic markers in men candidate to prostate biopsy

2012

Brachytherapy heterogeneity correction algorithm

2011

El objetivo de este trabajo de investigación es el estudio de la influencia de heterogeneidades de los tejidos en la dosimetría de braquiterapia. En concreto, hemos desarrollado un algoritmo que tiene en cuenta las calcificaciones localizadas dentro de la próstata y corrige la dosis de referencia en agua. Este algoritmo está basado en un modelo analítico y es aplicable a Sistemas de Planificación del Tratamiento (TPS) comerciales. El modelo analítico tiene un fundamento teórico consistente, y se basa en los valores de referencia (caso homogéneo) y en la definición de una longitud efectiva, que transforma el recorrido dentro de la calcificación en distancias mayores. La energía depositada en…

Immunological micro and macroenvironment modifications for the early diagnosis and prognostication of breast and prostate adenocarcinomas

Hybrid descriptive-inferential method for key feature selection in prostate cancer radiomics

2021

In healthcare industry 4.0, a big role is played by radiomics. Radiomics concerns the extraction and analysis of quantitative information not visible to the naked eye, even by expert operators, from biomedical images. Radiomics involves the management of digital images as data matrices, with the aim of extracting a number of morphological and predictive variables, named features, using automatic or semi-automatic methods. Multidisciplinary methods as machine learning and deep learning are fully involved in this field. However, the large number of features requires efficient and effective core methods for their selection, in order to avoid bias or misinterpretations problems. In this work, t…

“The risk of age”? Early detection test, prostate cancer and practices of self

2010

Abstract Drawing on Rose and Novas’s concept of “biological citizenship” and Michel Foucault's "practices of self", this paper reflects on how men become agents of their own therapeutic regimens, and yet internalise messages of risk and practices of self within early detection of prostate cancer discourses in the late 20th century. In doing so, it traces the ways in which concepts of age, gender and risk converge at the problematic site of prostate cancer and preventative health strategies, both of the state and the medical profession. Analysing how insecurities have simultaneously resulted in over-promoting and over-diagnosing risk, thereby blurring the lines between normal and pathologica…

Identification of Metastasis Associated Antigen 1 (MTA1) by Serological Screening of Prostate Cancer cDNA Libraries

2008

Over the past 10 years the serological analysis of recombinant cDNA expression libraries (SEREX) has proved to be an effective method for the identification of tumour antigens. In the present study, two prostate cancer libraries were constructed and screened using autologous sera. Fifty five genes were isolated, including 46 known genes and 9 previously uncharacterised genes. Among the known genes, a metastasis-associated gene, MTA1, previously identified by differential cDNA hybridisation, was preferentially expressed in a panel of malignant tissues compared with normal tissues, as analysed by reverse transcriptase-polymerase chain reaction (RT-PCR). MTA1 transcripts were observed to be ov…

WE-C-108-08: Organ Doses in a Male Phantom Undergoing High-Dose-Rate Brachytherapy Applied to the Prostate

2013

Purpose: The aim of this study was to obtain equivalent doses to radiosensitive organs when applying high‐dose‐rate (HDR) brachytherapy to the prostate using60 Co or 192 Ir sources, and in comparison to external‐beam radiotherapy (EBRT) modalities. Methods: Monte Carlo simulations in Geant4 were performed using a voxelized adult reference man described in Publication 110 by the International Commission on Radiological Protection (ICRP). Point sources of 60Co or 192Ir with photon energy spectra corresponding to those exiting their capsules were placed in the center of the prostate. Equivalent doses per therapeutic absorbed dose to the prostate were obtained in several radiosensitive organs. …