Search results for "Protease"

showing 3 items of 463 documents

Mast cells as protectors of health.

2019

Mast cells (MCs), which are well known for their effector functions in T(H)2-skewed allergic and also autoimmune inflammation, have become increasingly acknowledged for their role in protection of health. It is now clear that they are also key modulators of immune responses at interface organs, such as the skin or gut. MCs can prime tissues for adequate inflammatory responses and cooperate with dendritic cells in T-cell activation. They also regulate harmful immune responses in trauma and help to successfully orchestrate pregnancy. This review focuses on the beneficial effects of MCs on tissue homeostasis and elimination of toxins or venoms. MCs can enhance pathogen clearance in many bacter…

tumorImmunologyvenomTryptaseMast cell; innate immunity; infection; mast cell protease; tumor; pregnancy; venom; toxin; central nervous system traumaInfectionsCell DegranulationMast Cell ; Innate Immunity ; Infection ; Mast Cell Protease ; Tumor ; Pregnancy ; Venom ; Toxin ; Central Nervous System TraumaImmune systemCathelicidinsPregnancymedicineImmunology and AllergyAnimalsHomeostasisHumansEmbryo ImplantationMast CellsCNS traumatoxininnate immunityTissue homeostasismast cell proteaseToll-like receptorTumor microenvironmentInnate immune systembiologybusiness.industryDegranulationMast cellhumanitiesImmunity InnateToll-Like Receptor 2infectionddc:medicine.anatomical_structureImmunologybiology.proteinFemalepregnancybusinessmast cell
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New developments in the management of hepatitis C virus infection: focus on boceprevir

2012

Chronic hepatitis C virus infection is an important public health problem, and the standard treatment (combination of pegylated interferon-α and ribavirin) has an effectiveness rate of only 40%-50%. Novel virus-specific drugs have recently been designed, and multiple compounds are under development. The approval for the clinical use of direct-acting antivirals in 2011 (boceprevir [BOC] and telaprevir, viral NS3 protease inhibitors) has increased recovery rates by up to 70%. Therefore, a highly effective treatment has been envisioned for the first time. This paper focuses on BOC and the implementation of new BOC-based treatment regimes.

viral resistanceNS3business.industryvirusesRibavirinHepatitis C virusStandard treatmentprotease inhibitorsReviewmedicine.disease_causeVirologyVirusTelaprevirchemistry.chemical_compoundchemistryBoceprevirHCVantiviral therapyMedicineEffective treatmentbusinessmedicine.drugBiologics: Targets and Therapy
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Biochemical and structural analysis of the NS5B RNA-dependent RNA polymerase of the hepatitis C virus.

2000

Hepatitis C virus (HCV), the major causative agent of chronic and sporadic non-A, non-B hepatitis worldwide, is a distinct member of the Flaviviridae virus family. These viruses have in common a plus-strand RNA genome that is replicated in the cytoplasm of the infected cell via minus-strand RNA intermediates. Owing to the lack of reliable cell culture systems and convenient animal models for HCV, the mechanisms governing RNA replication are not known. As a first step towards the development of appropriate in vitro systems, we expressed the NS5B RNA-dependent RNA polymerase (RdRp) in insect cells, purified the protein to near homogeneity and studied its biochemical properties. It is a primer…

virusesHepatitis C virusGenetic VectorsRNA-dependent RNA polymeraseHepacivirusViral Nonstructural Proteinsmedicine.disease_causeCell LineSubstrate Specificitychemistry.chemical_compoundTranscription (biology)Sequence Analysis ProteinVirologyRNA polymeraseRibavirinmedicineHumansNS5BPolymeraseHepatologybiologyRNANucleosidesDNA-Directed RNA PolymerasesRNA-Dependent RNA PolymeraseVirologyRecombinant ProteinsNS2-3 proteaseInfectious DiseaseschemistryMutationbiology.proteinRNABaculoviridaeJournal of viral hepatitis
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