Search results for "Protection"
showing 10 items of 1623 documents
Land degradation a matter of attitude? A case study from southern Transylvania (Romania)
2016
A better public perception and knowledge on land degradation increases the individual and collective responsibility in land use and land management. Based on interviews, this paper presents results of evaluation of public perception and attitude towards degrading phenomena in the central part of Romania, an area prone to geomorphologic processes, with different land uses and a high proportion of degraded land. The research reveals natural causes, improper land use, categories of land owned, socio-economic causes and involvement of institutions as key aspects of public perception. Our research could be useful in the identification and design of measures in regional planning to attract popula…
HyperIO: A Hypervisor-Based Framework for Secure IO
2023
Malware often attempts to steal input and output through human interface devices to obtain confidential information. We propose to use a thin hypervisor, called “HyperIO”, to realize a secure path between input and output devices using a partial implementation of device drivers. We apply our approach using two security systems built on HyperIO: FireSafe and ClipCrypt. FireSafe is a web browser extension which allows a remote web server to display and receive sensitive user information securely. ClipCrypt enables the user to securely enter and view their confidential information in commodity Windows applications.
Nano- and microplastic analysis: Focus on their occurrence in freshwater ecosystems and remediation technologies
2019
Plastic pollution is a global problem since 2016 when its production reached 322 million tonnes, excluding fibers. Daily discharges of microplastics (MPs, defined as <5 mm in size) are estimated in the range of 50,000 up to 15 million particles, whereas no information on nanoplastic (NP, <100 nm) release is available yet. Different processes further degraded these materials producing more MPs and NPs. This review attempts to fill the void of information on the state-of-art analysis of MPs and NPs (recently identified as emerging contaminants) and provides a critical overview on modern instrumentation, newly developed workflows, and promising techniques for their characterization (Raman and …
Oxidative stress neuroinflammation and cellular stress response in sensorineural hearing loss: novel nutritional therapeutical approaches
2016
This study is intended to validate the hypothesis that changes in the redox state of glutathione, the major endogenous antioxidant, associated with the abnormal expression and activity of cytoprotective vitagenes, which in normal conditions are expressed only at low level may represent a critical factor, involved in the physiopathological changes associated to degenerative damage occurring in cochlear diseases. Moreover modulation of stress responsive vitagenes by nutritional antioxidants can be an effective therapeutic strategy to minimize consequences of oxidative stress associated to the pathogenesis and course of sensorineural hearing loss. One therapeutic approach can be antioxidant su…
The perception of abandoned farmland by local people and experts: Landscape value and perspectives on future land use
2013
Abstract Abandonment of agricultural land is a common feature of areas undergoing a range of urbanisation and marginalisation processes across Europe and beyond. This is also the case in Latvia, particularly in the period since 1990, when after regaining independence from the Soviet Union land was restored to its previous owners or their descendants. Many of these people have moved to cities and lack the interest in or the necessary capital for starting farming enterprises. As a result, large areas of land were abandoned, leading to spontaneous afforestation and with associated changes in landscape structure, ecological function and aesthetic value. While there has been an increase in resea…
Protection Motivation Theory in Information Systems Security Research
2021
Protection motivation theory (PMT) is one of the most commonly used theories to examine information security behaviors. Our systematic review of the application of PMT in information systems (IS) security and the comparison with its application for decades in psychology identified five categories of important issues that have not yet been examined in IS security research. Discussing these issues in terms of why they are relevant and important for IS security, and to what extent IS research has not considered them, offers new research opportunities associated with the study of PMT and IS security threats. We suggest how future studies can approach each of the open issues to provide a new roa…
From risk assessment to in-context trajectory evaluation - GMOs and their social implications
2011
Purpose: Over the past twenty years, GMOs have raised enormous expectations, passionate political controversies, and an on-going debate on how should these technologies be assessed. Current risk-assessment procedures generally assess GMOs in terms of their potential risk of negatively affecting human health and the environment. Yet, is this risk-benefit approach appropriate to a deliver a robust assessment of GMOs? In this paper, we question the validity of current risk-assessment from both a social and an ecological perspective, and we elaborate an alternative approach, namely in-context trajectory evaluation Methods: This paper combines frame analysis, context analysis and eco-social anal…
Galectin-3 Impairment of MYCN-Dependent Apoptosis-Sensitive Phenotype Is Antagonized by Nutlin-3 in Neuroblastoma Cells
2012
MYCN amplification occurs in about 20-25% of human neuroblastomas and characterizes the majority of the high-risk cases, which display less than 50% prolonged survival rate despite intense multimodal treatment. Somehow paradoxically, MYCN also sensitizes neuroblastoma cells to apoptosis, understanding the molecular mechanisms of which might be relevant for the therapy of MYCN amplified neuroblastoma. We recently reported that the apoptosis-sensitive phenotype induced by MYCN is linked to stabilization of p53 and its proapoptotic kinase HIPK2. In MYCN primed neuroblastoma cells, further activation of both HIPK2 and p53 by Nutlin-3 leads to massive apoptosis in vitro and to tumor shrinkage an…
P08 Analysis of Nrf2-downstream targets after fumarate treatment in dorsal root ganglia—an anti-inflammatory therapy in neurodegenerative disease?!
2012
Background Dimethylfumarate (DMF) is a new disease modifying therapy. Several studies have shown convincing data after DMF therapy in both autoimmune inflammatory diseases and neurodegenerative disorders like Huntington9s disease (HD). DMF exerts neuroprotective effects via induction of the nuclear factor E2-related factor 2 (Nrf2) and detoxification pathways. Although the exact mechanisms that lead to neurodegeneration are not fully understood the contribution of oxidative stress inducing neurodegeneration is assumed. Aims To analyse the effects of DMF on axonal growth and regeneration and to describe the influence of DMF on the Nrf2-pathway. Methods/techniques We thus investigated the eff…
Mildronate improves cognition and reduces amyloid-β pathology in transgenic Alzheimer's disease mice
2013
Mildronate, a carnitine congener drug, previously has been shown to provide neuroprotection in an azidothymidine-induced mouse model of neurotoxicity and in a Parkinson's disease rat model. The aim of this study was to investigate the effects of mildronate treatment on cognition and pathology in Alzheimer's disease (AD) model mice (APP(SweDI)). Mildronate was administered i.p. daily at 50 or 100 mg/kg for 28 days. At the end of treatment, the animals were behaviorally and cognitively tested, and brains were assessed for AD-related pathology, inflammation, synaptic markers, and acetylcholinesterase (AChE). The data show that mildronate treatment significantly improved animal performance in w…