Search results for "Protection"
showing 10 items of 1623 documents
Guanosine Protects Glial Cells Against 6-Hydroxydopamine Toxicity
2014
Increasing body of evidence indicates that neuron-neuroglia interaction may play a key role in determining the progression of neurodegenerative diseases including Parkinson’s disease (PD), a chronic pathological condition characterized by selective loss of dopaminergic (DA) neurons in the substantia nigra. We have previously reported that guanosine (GUO) antagonizes MPP+-induced cytotoxicity in neuroblastoma cells and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA) and beta-amyloid-induced apoptosis of SH-SY5Y cells. In the present study we demonstrate that GUO protected C6 glioma cells, taken as a model system for astrocytes, from 6-OHDA-induced neurotoxicity. We show tha…
Experimental Hyperthermia during Cardiac Arrest and CPR Is Associated with Severe Spontaneous Hypothermia in Mice
2012
Background: Since genetically engineered mice are becoming more and more available, these animals become of high interest to study physiologic and pathophysiologic pathways of brain ischemia. The aim of this study was to examine body temperature (Tb), physical activity variation and neurohistopathology in mice exposed to normothermic and hyperthermic cardiac arrest and cardiopulmonary resuscitation (CA/CPR). Methods: Male C57Bl/6 mice weighing 22 - 27 g were implanted intraperitoneally with a radio telemeter and subjected to 10 min cardiac arrest followed by cardiopulmonary resuscitation. Normothermia (37.5°C) or hyperthermia (39.0°C) was induced by controlling pericranial temperature durin…
The neuroprotective actions of corticotropin releasing hormone
2005
Corticotropin-releasing hormone (CRH) modulates the activity of the hypothalamic-pituitary-adrenal (HPA) axis, and has a key role in mediating neuroendocrine effects that occur in response to stressful stimuli. Disruption of the CRH system however has been shown to be closely associated with the progression of Alzheimer's disease (AD), and these observations prompted an investigation into the potential neuroprotective effects of the hormone. In addition to its regulatory affects on the molecular processes that underlie AD i.e., amyloid precursor protein (APP) processing and potentially tau phosphorylation, evidence is provided that the neuroprotective effects of CRH are mediated by a number…
RECENSIONE A A.C. NAZZARO, DIRITTO ALL'IMMAGINE E LOGICHE DI MERCATO. PROFILI DI DIRITTO SPORTIVO
2012
LO SCRITTO DELLA NAZZARO SI SEGNALA PER UN'INTERESSANTE DISAMINA DEL TEMA DELLA TUTELA DELL'IMMAGINE SIA IN UNA PROSPETTIVA DI DIRITTO COMUNE, SIA NELLA PARTICOLARE PROSPETTIVA DEL DIRITTO SPORTIVO. AMBITO IN CUI IL DIRITTO ALL'IMMAGINE ASSUME CONNOTAZIONI AFFATTO PECULIARI. THE WRITING IS NOTED FOR CONSIDERATION OF AN INTERESTING TOPIC OF THE PROTECTION OF THE IMAGE IN A PERSPECTIVE OF COMMON LAW, AND IN PARTICULAR PERSPECTIVE OF SPORTS LAW. CONTEXT IN WHICH THE IMAGE HAS PECULIAR CONNOTATION
Motivational Impact of Environmental Management on the Environmental Awareness in a Workplace
2021
PURPOSE: The aim of this article is to determine the level of motivational impact of environmental management (EM) on the environmental awareness of employees.
Immigrati e diritti sociali: parità di trattamento e tutela multilivello
2017
Il saggio analizza la tutela antidiscriminatoria di cui godono i lavoratori immigrati all'insegna di una prospettiva multilivello: più in particolare viene descritto il complesso di strumenti normativi del diritto nazionale ed europeo a tutela delle situazioni giuridiche soggettive degli immigrati (ad es., in materia di sicurezza sociale), per come interpretato dalla Corte Costituzionale, dalla Corte di Giustizia e dalla Corte EDU. Da ultimo, vengono analizzati i recenti orientamenti giurisprudenziali, che oscillano tra l'affievolimento del principio paritario in ragione di sempre più stringenti vincoli di bilancio, e la tendenziale parificazione tra cives e non cives alla luce del principi…
Environmental impact of antifouling technologies: state of art and perspectives
2001
1. Marine fouling affects most man-made surfaces temporarily or permanently immersed in the sea, resulting in significant (or substantial) economic costs. Intense research is aimed at preventing or reducing fouling. 2. The most widespread solution to avoid fouling formation is to make surfaces unsuitable for settlers, coating them with antifouling (AF) paints containing toxic compounds. Most AF agents (e.g. tributyltin, (TBT)) have undesirable effects on non-target species, including commercially important organisms. 3. To date, the use of TBT in AF paints has been restricted (but not prohibited) in a number of countries and new biocides are in use. 4. The environmental problems posed to ma…
Conséquences du refus par un maître auxiliaire d'une affectation hors de ses voeux
1997
International audience
La quasi-gratuité de l'exercice du droit de rétractation du consommateur : l'application aux frais de livraison
2010
International audience
Methylprednisolone neutralizes the beneficial effects of erythropoietin in experimental spinal cord injury
2005
Inflammation plays a major pathological role in spinal cord injury (SCI). Although antiinflammatory treatment using the glucocorticoid methyprednisolone sodium succinate (MPSS) improved outcomes in several multicenter clinical trials, additional clinical experience suggests that MPSS is only modestly beneficial in SCI and poses a risk for serious complications. Recent work has shown that erythropoietin (EPO) moderates CNS tissue injury, in part by reducing inflammation, limiting neuronal apoptosis, and restoring vascular autoregulation. We determined whether EPO and MPSS act synergistically in SCI. Using a rat model of contusive SCI, we compared the effects of EPO [500-5,000 units/kg of bod…