Search results for "Protection"
showing 10 items of 1623 documents
Nanostructures materials for protection and consolidation of ancient structures
2014
The preservation and appreciation of the built cultural heritage is of particular interest, through researches and studies on innovative technologies. As evidenced by the good results obtained in some interventions both at national and international level, activities for the conservation of cultural heritage must be the result of synergies and collaboration of interdisciplinary groups, science and knowledge: architecture, engineering, technology, sociology, economics, urban planning, legislation must be managed and planned to work together. The theme of protection and consolidation of ancient structures, applying non-traditional technologies, requires a comprehensive overview of strategies …
Project report : Methodology for terminology harmonisation
2020
A common understanding of language and concepts used is essential for any meaningful communication. For large rescue operations effective communication is crucial to save lives. Such operations can require cooperation among first responders from several sectors with a different understanding of terms and concepts. Redningshåndboka (the National Rescue handbook) provides a common glossary for use across all sectors for their communications in training and practice. However, today each sector maintains their own glossaries, acronyms and jargon, causing potential misunderstandings in joint operations. In this report we propose a way to apply the Norwegian Public Management Standard from the No…
Visitor Regulations vs Rules for visiting Morizsala
1913
Regulations issued by the Riga Society of Naturalists (Naturforscher-Verein zu Rīga; 1845 – 1939) for visitors to Moricsala. The rules were created by approving the first nature protected area in Latvia. The material is stored in the Botany and Mycology collections of the Museum of the University of Latvia.
Biologically based models of cancer risk in radiation research
2020
PURPOSE: In radiation risk analysis the state-of-the-art approach is based on descriptive models which link excess rates of cancer incidence and mortality to radiation exposure by statistical association. To estimate the number of sporadic and radiation-induced cases descriptive models apply parametric dose response function which directly determine the radiation risk. In biologically-based models of cancer risk (BBCR models) dose responses are implemented for key events on the biological level such as early mutations or clonal expansion of initiated cells. Influenced by radiation these events then shape the risk response on the epidemiological level. Although BBCR models facilitate a more …
Extracellular Vesicles in neural cell interaction and CNS homeostasis
2021
Abstract Central nervous system (CNS) homeostasis critically depends on the interaction between neurons and glia cells. Extracellular vesicles (EVs) recently emerged as versatile messengers in CNS cell communication. EVs are released by neurons and glia in activity‐dependent manner and address multiple target cells within and outside the nervous system. Here, we summarize the recent advances in understanding the physiological roles of EVs in the nervous system and their ability to deliver signals across the CNS barriers. In addition to the disposal of cellular components via EVs and clearance by phagocytic cells, EVs are involved in plasticity‐associated processes, mediate trophic support a…
Delivery on call: exosomes as “care packages” from glial cells for stressed neurons
2013
Abstract Communication between cells is a basic requirement for proper nervous system function. Glial cells execute various functions, operating in close coordination with neurons. Recent research revealed that cell communication is mediated by the exchange of extracellular vesicles, which are also secreted by glial cells and neurons. Extracellular vesicles comprise exosomes and microvesicles, which deliver proteins and ribonucleic acids to target cells. As a result of transfer, the vesicle cargo components can modulate the phenotype of recipient cells. Here, we discuss the characteristics and functions of extracellular vesicles in general and in particular in the central nervous system, …
The Role of Erythropoietin in Neuroprotection: Therapeutic Perspectives
2007
Nervous system diseases are very complex conditions comprising a large variety of local and systemic responses. Several therapeutic agents interfering with all or in part the biochemical steps that ultimately cause neuronal death have been demonstrated to be neuroprotective in preclinical models. However, all the agents so far investigated have inexorably failed in the phase III trials carried out. A large body of evidence suggests that the hormone erythropoietin (EPO), besides its well-known hematopoietic action, exerts beneficial effects in the central nervous system. EPO's effect has been assessed in several experimental models of brain and spinal cord injury thus becoming a serious cand…
Genetic Models of the Endocannabinoid System
2009
The endocannabinoid (ECB) system comprises cannabinoid receptors, ECBs and the whole machinery for the synthesis and degradation of ECBs. It has emerged as an important signalling system in the nervous system, controlling numerous physiological processes, including synaptic transmission, learning and memory, reward, feeding, neuroprotection, neuroinflammation, and neural development. This system is also implicated in various diseases of the nervous system, and thus has become a promising therapeutic target. The use of genetically modified mice has contributed crucially to our rapidly expanding knowledge of the ECB system. In this chapter, the existing mouse mutants targeting the ECB system …
Plasma gangliosides and age-related macular degeneration
2013
Purpose Age-related macular degeneration (AMD) is a multifactorial and polygenic disease and is the main cause of vision loss in developed countries after 50 years old. Indeed, dry AMD leads to progressive retinal atrophy and exsudative AMD induces a rapid alteration of the macula through neovascularisation. Gangliosides (GG) make a wide and heterogeneous family of sialic-acid-containing glycosphingolipids, composed of a sugar chain branched on a ceramide. They are major components of cellular membranes and are particularly abundant in the brain and nervous tissue, including retina. They are also found circulating in the plasma. GG are known for their neuroprotective properties in the nervo…
Emerging Therapeutic Strategies for Traumatic Spinal Cord Injury
2020
Spinal cord injury (SCI) is a debilitating neurologic condition with tremendous socioeconomic impact on affected individuals and the health care system. The treatment of SCI principally includes surgical treatment and marginal pharmacologic and rehabilitation therapies targeting secondary events with minor clinical improvements. This unsuccessful result mainly reflects the complexity of SCI pathophysiology and the diverse biochemical and physiologic changes that occur in the injured spinal cord. Once the nervous system is injured, cascades of cellular and molecular events are triggered at varying times. Although the cascade of tissue reactions and cell injury develops over a period of days …