Search results for "Protective"
showing 10 items of 512 documents
Daidzein has neuroprotective effects through ligand-binding-independent PPARγ activation.
2011
Phytoestrogens are a group of plant-derived compounds that include mainly isoflavones like daidzein. Phytoestrogens prevent neuronal damage and improve outcome in experimental stroke; however, the mechanisms of this neuroprotective action have not been fully elucidated. In this context, it has been postulated that phytoestrogens might activate the peroxisome proliferator-activated receptor-γ (PPARγ), which exerts neuroprotective effects in several settings. The aim of this study was to determine whether the phytoestrogen daidzein elicits beneficial actions in neuronal cells by mechanisms involving activation of PPARγ. Our results show that daidzein (0.05-5 μM) decreases cell death induced b…
Expression and regulation of mPer1 in immortalized GnRH neurons.
2003
Hypothalamic GnRH (gonadotropin-releasing hormone) neurons play a critical role in the initiation and maintenance of reproduction competence. Using the mouse GnRH neuronal cell line, GT1-7, we have characterized the expression of the gene mPer1, a recognized key element of the mammalian circadian clockwork. Both mPer1 transcripts and the 136 kDa mPER1 gene product could be detected in these cells. Immunocytochemical analysis also confirmed expression of mPER1 both in vitro and in vivo in GnRH neurons. Activation of cyclic AMP signalling pathways in vitro elevated GnRH secretion as well as mPer1 expression and nuclear mPER1 immunoreactivity. As mPER1 is known to feedback on transcriptional a…
Use of alcohol, tobacco, cannabis and other drugs in adolescence: effects of family and neighborhood
2015
El objetivo de este estudio fue analizar los factores de protección o riesgo de los estilos educativos parentales para el consumo de alcohol, tabaco, cannabis y otras drogas, considerando la interacción de los estilos parentales con la peligrosidad del barrio. A partir de las respuestas de 628 adolescentes, 369 mujeres (58.8%) y 259 hombres (41.2%) entre 15 y 17 años (M = 16.03 años, DT = 0.79 años), se clasificaron las familias según el estilo educativo (autorizativo, indulgente, autoritario o negligente) y el riesgo percibido en el barrio (alto o bajo). Los resultados no mostraron interacciones, pero sí efectos principales de los estilos educativos y del riesgo percibido. Los adolescentes…
Risk and protective factors for (internet) gaming disorder: A meta-analysis of pre-COVID studies.
2023
This large-scale meta-analysis aimed to provide the most comprehensive synthesis to date of the available evidence from the pre-COVID period on risk and protective factors for (internet) gaming disorder (as defined in the DSM-5 or ICD-11) across all studied populations. The risk/protective factors included demographic characteristics, psychological, psychopathological, social, and gaming-related factors. In total, we have included 1586 effects from 253 different studies, summarizing data from 210557 participants. Apart from estimating these predictive associations and relevant moderating effects, we implemented state-of-the-art adjustments for publication bias, psychometric artifacts, and o…
Screening of complicated grief
2013
Objetivo: Conocer en profundidad el fenómeno del duelo complicado o patológico, y recabar aquellos indicadores de detección y evaluación que nos permitan su pronta identificación en la práctica clínica. Método: Tras una amplia revisión de la literatura científica aparecida en los últimos años, y a la luz de nuestra experiencia profesional, se realizó una recopilación de los indicadores más significativos. Resultados: Presentamos los principales criterios diagnósticos e instrumentos de medida utilizados en la actualidad, que permiten a los profesionales del ámbito de la salud valorar con precisión posibles complicaciones en el proceso de duelo. Conclusiones: Contamos con importantes indicado…
A non-canonical chemical feedback self-limits nitric oxide-cyclic GMP signaling in health and disease
2018
Endothelial nitric oxide (NO) stimulates the heme protein, soluble guanylyl cyclase (sGC) to form vasoprotective cyclic GMP (cGMP). In different disease states such as pulmonary hypertension, NO-cGMP signaling is pharmacologically augmented, yet the pathomechanisms leading to its dysregulation are incompletely understood. Here we show in pulmonary artery endothelial cells that endogenous NO or NO donor compounds acutely stimulate sGC activity, but chronically down-regulate both sGC protein and cGMP formation. Surprisingly, this endogenous feedback mechanism was independent of canonical cGMP signaling via cGMP-dependent protein kinase. It did not involve thiol-dependent modulation, a process…
La resistenza di interfaccia calcestruzzo poroso-terreni a grana fina per il consolidamento di pendii mediante trincee drenanti profonde
2022
Le trincee drenanti profonde rappresentano uno dei metodi più efficaci per la mitigazione del rischio da frana, in pendii con falda idrica. Esse sono realizzate mediante pannelli o pali secanti. Il riempimento è costituito di calcestruzzo poroso o materiale granulare. Se le trincee sono adeguatamente “innestate” nel terreno stabile e il materiale di riempimento ha sufficiente resistenza e rigidezza come il calcestruzzo poroso, si ha ulteriore in-cremento di resistenza a taglio per effetto shear keys, oltre a quello derivante dalla riduzione delle pressioni in-terstiziali. L’incremento di resistenza è dovuto sia alla resistenza all’interfaccia calcestruzzo–terreni sia a quella intrinseca del…
Beyond the Educational Context: Relevance of Intrinsic Reading Motivation During COVID-19 Confinement in Spain
2021
What role could have intrinsic motivation toward reading in an extraordinary situation like the recent confinement? This research examines the relationship between intrinsic reading motivation (IRM) and reading habits in an adult population considering types of reading (for leisure, work/study, social networks, and news), gender, and distress generated by the coronavirus disease 2019 (COVID-19) pandemic. Participants were 3,849 adults from Spain who were surveyed about their reading practices: before, during the first weeks, and after several weeks of confinement. Linear mixed effects models (LMMs) were used to analyze data. Results showed a three-way interaction between reading frequency, …
Camouflage in arid environments: the case of Sahara-Sahel desert rodents
2020
Deserts and semi-deserts, such as the Sahara-Sahel region in North Africa, are exposed environments with restricted vegetation coverage. Due to limited physical surface structures, these open areas provide a promising ecosystem to understand selection for crypsis. Here, we review knowledge on camouflage adaptation in the Sahara-Sahel rodent community, which represents one of the best documented cases of phenotype-environment convergence comprising a marked taxonomic diversity. Through their evolutionary history, several rodent species from the Sahara-Sahel have repeatedly evolved an accurate background matching against visually-guided predators. Top-down selection by predators is therefore …
River-bed erosion due to changing boundary conditions: performance of a protective measure
2018
Abstract. Due to the introduction of man-made sediment barriers along a river, the amount of sediment load entering the downstream river reach is different to that leaving the reach, and erosion processes occur downstream of the barrier itself. Designers are often required to take into account the scouring process and to include adequate protective measures against the local scour. This paper addresses the performance of bio-engineering protective measures against the erosion process. In particular, a green carpet, realized with real flexible vegetation, has been used as the protective measure against erosion processes downstream of a rigid bed. Analyses are based on experimental work carri…