Search results for "Protein aggregation"

Multistage pathways involved in thermal aggregation processes of proteins.

2004

Disaccarides effects on thermal aggregation of Bovine Serum Albumin

2004

Thermal aggregation of bovine serum albumin close to the isoelectric point.

2006

Different aggregation pathways of human and bovine Serum Albumin.

2004

Thermal aggregation of human and bovine serum albumin in the low concentration regime

2005

Effects of Disaccarides On Thermal Aggregation of Bovine Serum Albumin.

2004

Different degrees in protein thermal aggregation processes in presence of trealose

2004

Observation of the Early Structural Changes Leading to the Formation of Protein Superstructures.

2014

Formation of superstructures in protein aggregation processes has been indicated as a general pathway for several proteins, possibly playing a role in human pathologies. There is a severe lack of knowledge on the origin of such species in terms of both mechanisms of formation and structural features. We use equine lysozyme as a model protein, and by combining spectroscopic techniques and microscopy with X-ray fiber diffraction and ab initio modeling of Small Angle X-ray Scattering data, we isolate the partially unfolded state from which one of these superstructures (i.e., particulate) originates. We reveal the low-resolution structure of the unfolded state and its mechanism of formation, hi…