Search results for "Proto-Oncogene Proteins c-sis"

showing 2 items of 12 documents

Ovine Carotid Artery-Derived Cells as an Optimized Supportive Cell Layer in 2-D Capillary Network Assays

2014

PLoS one 9(3), e91664 (2014). doi:10.1371/journal.pone.0091664

Vascular Endothelial Growth Factor APathologyCellBecaplerminlcsh:MedicineCardiovascularUmbilical veinUmbilical CordDrug DiscoveryMolecular Cell BiologyBiological Systems EngineeringMyocyteCardiovascular Imaginglcsh:ScienceMultidisciplinaryProto-Oncogene Proteins c-sisAnimal ModelsFlow CytometryEndothelial stem cellBevacizumabmedicine.anatomical_structureCarotid ArteriesMonoclonalMedicineImmunohistochemical AnalysisResearch ArticleBiotechnologymedicine.medical_specialtyCell typeDrugs and DevicesDrug Research and DevelopmentMyocytes Smooth MuscleImmunologyBiomedical EngineeringBioengineeringBiologyAntibodies Monoclonal HumanizedCell LineModel OrganismsVascular Biologymedicine.arterymedicineAnimalsHumansBiologySheeplcsh:REndothelial CellsFeeder CellsUmbilical arteryMolecular biologyVascular Endothelial Growth Factor Receptor-2Coculture TechniquesCapillariesCell cultureImmunologic Techniqueslcsh:QCytometry
researchProduct

Ethanol inhibits astroglial cell proliferation by disruption of phospholipase D-mediated signaling.

2002

The activation of phospholipase D (PLD) is a common response to mitogenic stimuli in various cell types. As PLD-mediated signaling is known to be disrupted in the presence of ethanol, we tested whether PLD is involved in the ethanol-induced inhibition of cell proliferation in rat cortical primary astrocytes. Readdition of fetal calf serum (FCS) to serum-deprived astroglial cultures caused a rapid, threefold increase of PLD activity and a strong mitogenic response; both effects were dependent on tyrosine kinases but not on protein kinase C. Ethanol (0.1-2%) suppressed the FCS-induced, PLD-mediated formation of phosphatidic acid (PA) as well as astroglial cell proliferation in a concentration…

medicine.medical_specialtyPlatelet-derived growth factorIndolestert-Butyl Alcoholmedicine.medical_treatmentButanolsBecaplerminPhosphatidic AcidsNerve Tissue ProteinsBiologyBiochemistryCulture Media Serum-FreeCellular and Molecular Neurosciencechemistry.chemical_compound1-ButanolInternal medicineLysophosphatidic acidmedicinePhospholipase DAnimalsPhosphorylationProtein kinase APlatelet-Derived Growth FactorEndothelin-1EthanolPhospholipase DCell growthGrowth factorPhosphatidic acidDNAProto-Oncogene Proteins c-sisProtein-Tyrosine KinasesGenisteinGrowth InhibitorsCell biologyRatsEndocrinologychemistryFetal Alcohol Spectrum DisordersAstrocyteslipids (amino acids peptides and proteins)Signal transductionVanadatesProtein Processing Post-TranslationalCell DivisionSignal TransductionJournal of neurochemistry
researchProduct