Search results for "Protocol"

The Long and Winding Road to Useful Predictive Factors for Anti-EGFR Therapy in Metastatic Colorectal Carcinoma: The KRAS/BRAF Pathway

2010

Monoclonal antibodies targeting the epidermal growth factor receptor (EGFR) have improved outcomes for patients with metastatic colorectal carcinoma. Among patients not carrying activating mutations in the KRAS gene, only a limited number will experience tumor response to these therapeutic agents. The role of BRAF mutations in determining resistance to this treatment is emerging through preclinical and clinical studies. Standardization and validation of laboratory mutation analysis is needed to allow an optimal use of anti-EGFR therapies in the management of colorectal carcinoma. Clinical single-arm and randomized studies were conducted both in first-line and refractory settings to evaluate…

PROTOCOL: Organised crime groups: A systematic review of individual‐level risk factors related to recruitment

2019

Design of a Neural Network Model as a Decision Making Aid in Renal Transplant

2004

This paper presents the application of this new tool of data processing in the study of the problem that arises when a renal transplant is indicated for a paediatric patient. Its aim is the development and validation of a neural network based model which can predict the success of the transplant over the short, medium and long term, using pre-operative characteristics of the patient (recipient) and implant organ (donor). When compared to results of logistic regression, the results of the proposed model showed better performance. Once the model is obtained, it will be converted into a tool for predicting the efficiency of the transplant protocol in order to optimise the donor-recipient pair …

A practical protocol for calibration of nutrient removal wastewater treatment models

2011

Activated sludge models can be very useful for designing and managing wastewater treatment plants (WWTPs). However, as with every model, they need to be calibrated for correct and reliable application. Activated sludge model calibration is still a crucial point that needs appropriate guidance. Indeed, although calibration protocols have been developed, the model calibration still represents the main bottleneck to modelling. This paper presents a procedure for the calibration of an activated sludge model based on a comprehensive sensitivity analysis and a novel step-wise Monte Carlo-based calibration of the subset of influential parameters. In the proposed procedure the complex calibration i…

Enablers of the successful implementation of simulation exercises: a qualitative study among nurse teachers in undergraduate nursing education

2021

Abstract Background Simulation exercises are increasingly being used as a teaching method in the field of undergraduate nursing education. Thus, the present study sought to identify, describe and discuss enablers of the successful implementation of simulation exercises in undergraduate nursing education. Methods This study had a qualitative descriptive design and involved individual interviews conducted between November and December 2018 with six nurse teachers from three different university campuses in Norway. The transcribed interviews were analysed by means of a qualitative thematic analysis. Results The majority of the interviewees wanted to offer more simulation exercises as part of t…

A Matlab based interface for infrared thermographic diagnosis of pediatric musculoskeletal injuries

2016

Abstract Background and objective One of the main causes of emergency medical consultations done by children are musculoskeletal injures. In such cases, radiological tests are a common practice to diagnose the gravity of the trauma and determine the likely existence of a fracture. In order to avoid, or at least to reduce, the use of ionizing radiations with children, the infrared thermographic technique was studied as an alternative solution, since it is a non-harmful, non-invasive and non-contact technique, without excessive technical complications and moderate cost when compared to other types of imaging tools. Methodology When an infrared thermographic diagnostic test is performed, and o…

Emergency Clinical Trials

2010

Emergency clinical trials involve the administration of the study drug to healthy human volunteers or to patients under the supervision of a qualified investigator, usually a physician, pursuant to a reviewed protocol. Research in this field continues to grow because this department is often considered as a desirable place to conduct clinical research due to the broad and undifferentiated spectrum of acute conditions encountered. There are some specific aspects when studying emergency medicine that have to be taken into account. One of them is the emphasis on ultrarapid diagnosis and treatment to save the critically ill emergency patient. Keywords: emergency medicine; clinical trials; diagn…

Corrigendum: Elena+ Care for COVID-19, a Pandemic Lifestyle Care Intervention: Intervention Design and Study Protocol

2021

Protocol of acceptance, execution and management of positive Covid-19 patient in Interventional Radiology at the AORN Sant’Anna and San Sebastiano of…

2020

The Covid-19 emergency required healthcare facilities to redesign the care pathways in order to avoid the spread of the pandemic. Interventional Radiology which carries out an essential activity in a high specialty hospital environment is exposed at the forefront in all those minimally invasive diagnostic-therapeutic procedures in election and urgency. It was therefore necessary to apply, on the basis of the National, Regional and Company directives, a specific protocol to the patients belonging to the Hospital. A series of procedures have therefore been applied, ranging from acceptance, preparation, pre and post-treatment interventional to reduce the infectious disease risk. However, this …

Study Design in Medical Research

2009

Medical research studies can be split into five phases—planning, performance, documentation, analysis, and publication (1, 2). Aside from financial, organizational, logistical and personnel questions, scientific study design is the most important aspect of study planning. The significance of study design for subsequent quality, the relability of the conclusions, and the ability to publish a study are often underestimated (1). Long before the volunteers are recruited, the study design has set the points for fulfilling the study objectives. In contrast to errors in the statistical evaluation, errors in design cannot be corrected after the study has been completed. This is why the study design…