Search results for "Protocol"
showing 10 items of 1808 documents
Adverse events associated with encorafenib plus binimetinib in the COLUMBUS study: incidence, course and management.
2019
Abstract Background Dual inhibition of the mitogen-activated protein kinase pathway with BRAF/MEK inhibitor (BRAFi/MEKi) therapy is a standard treatment for BRAFV600-mutant metastatic melanoma and has historically been associated with grade III pyrexia or photosensitivity depending on the combination used. The objective of this study was to fully describe adverse events from the COLUMBUS study evaluating the most recent BRAF/MEK inhibitor combination encorafenib+binimetinib. Patients and methods Patients with locally advanced, unresectable or metastatic BRAFV600-mutant melanoma were randomised to receive encorafenib 450 mg once daily plus binimetinib 45 mg twice daily, encorafenib 300 mg on…
Membrane-bound exosomal HSP70 as a biomarker for detection and monitoring of malignant solid tumours: a pilot study
2019
Abstract Background Cancer is the second leading cause of death globally. Early detection and disease management lead to a better survival rate. Consequently, discovery of novel methods in cancer early diagnosis is a field of active research. Minimally invasive liquid biopsies are generating growing interest. Circulating tumour cells (CTCs) have been identified in patients’ blood; nevertheless, these cells are rare and heterogeneous. Exosomes are extracellular nanovesicles released into the extracellular environment via the endosomal vesicle pathway and found in different body fluids. Exosomes deliver bioactive cargo such as proteins, mRNA and miRNA to recipient cells in the tumour environm…
ERCP : Energy-Efficient and Reliable-Aware Clustering Protocol for Wireless Sensor Networks
2022
Wireless Sensor Networks (WSNs) have been around for over a decade and have been used in many important applications. Energy and reliability are two of the major problems with these kinds of applications. Reliable data delivery is an important issue in WSNs because it is a key part of how well data are sent. At the same time, energy consumption in battery-based sensors is another challenge. Therefore, efficient clustering and routing are techniques that can be used to save sensors energy and guarantee reliable message delivery. With this in mind, this paper develops an energy-efficient and reliable clustering protocol (ERCP) for WSNs. First, an efficient clustering technique is proposed for…
Digital Palaeography of Hieratic
2020
After a short history of research into hieratic palaeography, the first experiences with digital methods to conduct the study of handwritten documents, in Egyptology as well as in other fields, are presented. The needs and goals of a future digital palaeography are then explained in detail. Such a palaeography is expected to become a modern research tool for ancient Egyptian handwritings that allows the depiction, description, classification, and encoding of cursive signs and that includes information about the entire manuscripts and their materiality. In constructing such a tool, some questions are essential, for instance: How should the signs be represented—as image sections from a scan o…
An Overview on Solar Shading Systems for Buildings
2014
Abstract In recent years, different types of solar shading devices have been proposed, depending on building orientation, location, window characteristics, etc. They can contribute to improve or worsen building thermal and lighting performances both from an energy and comfort point of view. The present paper reports a critical analysis of some studies that investigate shading devices’ effects on building thermal and/or lighting performances. This article points out the difficulty in comparing the different results given the lack of uniformity between the studies, since they analysed buildings with different characteristics, locations and using various indices. Therefore a protocol to carry …
An integrated model for biological and physical process simulation in membrane bioreactors (MBR).
2011
Abstract Mathematical modelling of membrane bioreactors (MBRs) for wastewater treatment has targeted either the biological processes (treatment quality target) as well as various aspects of system management. However, the high number of interactions among the involved physical–chemical processes, hampers a straightforward mathematical modelling. This circumstance is much more emphasized for submerged MBR systems where the membrane is immersed in an aeration tank. One of the main crucial points that prevents a comprehensive understanding is the interpretation of the fouling phenomenon and its connections with the biological processes. An overall mathematical model for MBR has not been comple…
DSC: software tool for simulation-based design of control strategies applied to wastewater treatment plants.
2011
This paper presents a computer tool called DSC (Simulation based Controllers Design) that enables an easy design of control systems and strategies applied to wastewater treatment plants. Although the control systems are developed and evaluated by simulation, this tool aims to facilitate the direct implementation of the designed control system to the PC of the full-scale WWTP (wastewater treatment plants). The designed control system can be programmed in a dedicated control application and can be connected to either the simulation software or the SCADA of the plant. To this end, the developed DSC incorporates an OPC server (OLE for process control) which facilitates an open-standard communic…
Distributed consensus protocols for coordinating buyers
2003
In this paper, we introduce a distributed consensus protocol for coordinating orders of a network of buyers also called agents/decision makers. Each buyer chooses a different threshold strategy, defining its intention to place an order only if at least other l buyers will do the same. We prove that consensus is reached asymptotically globally and coordination is the same that if the decision making process would be centralized, namely, any decision maker (DM) has access to the thresholds of all other DMs and chooses to order or not. The proposed distributed protocol has the advantage that buyers do not have to communicate their threshold strategy in advance, and consensus is reached without…
OLSR Mesh Networks for Broadband Access: Enhancements, Implementation and Deployment
2008
In the context of an EU FP6 project, ADHOCSYS, we have developed a reliable and cost-effective solution for broadband Internet access in rural and mountainous areas. This solution is built based on multi-hop wireless mesh networking technologies and covers many aspects such as routing, reliability, QoS, security, self-configuration, self-healing, remote network monitoring, power management etc. In this paper, we present solely the routing aspect of the developed mesh network, focusing on new routing features that have been designed, implemented, and deployed in a real-life operational network. These new features are developed based on an extended version of the OLSR protocol. The test resul…
comparing two start-up strategies for MBRs: experimental study and mathematical modelling
2012
Abstract The performance of a membrane bioreactor (MBR), and mechanisms of fouling formation, may differ due to the start-up. Therefore, the start-up can constitute an aspect that critically influences MBR performance during its lifespan. Indeed, the start-up can influence the mechanisms of membrane fouling, which is of paramount importance in an MBR. In order to gain insights on the effects of the start-up, both experimental and mathematical modelling studies were carried out on an MBR pilot plant. The MBR pilot plant constituted of a hollow fibre membrane module, in a submerged configuration, was fed by real wastewater. Two experimental periods were carried out, lasting 65 days each, char…