Search results for "Protocol"
showing 10 items of 1808 documents
Combination chemotherapy with mitomycin C, vindesine and melphalan for refractory metastatic breast cancer.
1991
A combination of mitomycin C, vindesine and melphalan was administered to 33 patients with heavily pretreated refractory breast cancer. The overall response rate was 27% with a mean duration of more than 10.2 months. A stabilization with a mean duration of 5.1 months was seen in 56% of cases, while 20% of patients progressed. Gastrointestinal toxicity, mostly grade 1 or 2 nausea/vomiting was seen in 85% of cases, grade 1 or 2 leukopenia in 60% of patients, and grade 1 or 2 thrombocytopenia in 42%. Considering the good compliance of this regimen and the poor prognosis of patients with refractory advanced breast cancer, this combination can be useful as a palliative treatment of breast carcin…
Integrated Domain Model for Digital Rights Management
2004
Digital Rights Management (DRM) is an issue of controlling and managing digital rights over intellectual property. It has recently broadened its scope from being merely a content protection concern to description, identification, trading, protection, monitoring and tracking of rights over tangible or intangible assets. In our study we found out an essential problem of the domain: lack of models on an appropriate level of abstraction needed to support research and system development. Modelling, identifying and describing the core entities enable the rights management functionalities. This chapter contributes in recognizing the principal entities and providing detailed description on current …
Adaptogens in chemobrain (Part III): Antitoxic effects of plant extracts towards cancer chemotherapy-induced toxicity - transcriptome-wide microarray…
2019
Abstract Background Toxicity of chemotherapeutics is a serious problem in cancer therapy. Adaptogens are known to increase adaptability and survival organisms. Aim The aim of this study was to assess the effects of selected adaptogenic herbal extracts on FEC (fixed combination of 5-fluorouracil, epirubicin and cyclophosphamide) induced changes in transcriptome-wide microarray profiles of neuroglia cells. Another task of the study was to identify those genes, which are associated with FEC-induced hepato-, cardio– and nephrotoxicity to predict potential effects of andrographolide (AND), Andrographis herb, Eleutherococcus roots genuine extracts (ES), their fixed combination (AE) and the combin…
Adaptogens in chemobrain (Part I): Plant extracts attenuate cancer chemotherapy-induced cognitive impairment – Transcriptome-wide microarray profiles…
2019
Abstract Background Cancer chemotherapy-induced cognitive impairments are presumably associated with undesirable effects of chemotherapy on physiological functions of brain cells. Adaptogens are natural compounds or plant extracts increasing an organism's adaptability and survival in stress. They exhibited neuroprotective effects and increased cognitive functions in clinical studies in human beings. Hypothesis We hypothesized that selected adaptogenic plant extracts attenuate or prevent cancer chemotherapy-induced cognitive impairments. Aim We assessed the effects of selected adaptogenic herbal extracts on FEC (fixed combination 5-fluorouracil, epirubicin and cyclophosphamide) induced chang…
Inter-laboratory evaluation of the ISO standard 11063 "Soil quality - Method to directly extract DNA from soil samples"
2011
International audience; Extracting DNA directly from micro-organisms living in soil is a crucial step for the molecular analysis of soil microbial communities. However, the use of a plethora of different soil DNA extraction protocols, each with its own bias, makes accurate data comparison difficult. To overcome this problem, a method for soil DNA extraction was proposed to the International Organization for Standardization (ISO) in 2006. This method was evaluated by 13 independent European laboratories actively participating in national and international ring tests. The reproducibility of the standardized method for molecular analyses was evaluated by comparing the amount of DNA extracted, …
Hacia la integración del medio ambiente y el desarrollo sostenible en la región mediterránea
2018
I. INTRODUCCIÓN.- II. EL SISTEMA ORIGINARIO PARA LA PROTECCIÓN DEL MAR MEDITERRÁNEO CONTRA LA CONTAMINACIÓN: 1. Las Conferencias de Barcelona de 1975 y 1976. 2. Su desarrollo posterior.- III. EL PROCESO DE REVISIÓN: 1. La Conferencia Ministerial sobre Desarrollo Sostenible en el Mediterráneo. 2. Hacia la IX Reunión Ordinaria de las Partes Contratantes en el Convenio de Barcelona.- IV. EL NUEVO MARCO POLÍTICO: 1. La Resolución de Barcelona sobre el medio ambiente y el desarrollo sostenible en la cuenca mediterránea. 2. El Plan de acción para la protección del medio marino y el desarrollo sostenible de las zonas costeras del Mediterráneo (Fase II del PAM). 3. Los Sectores de actividades prior…
El Protocolo al Tratado Antártico sobre Protección del Medio Ambiente: algunas reflexiones
2018
Los autores que suscriben estas reflexiones ya analizaron en este mismo Anuario los orígenes y negociaciones que llevaron a la celebración del Protocolo al Tratado Antártico sobre Protección del Medio Ambiente. Nuestro objetico no es ahora el de analizar pormenorizadamente este instrumento jurídico, del que sea ha ocupado ya abundante y brillantemente la doctrina, sino sólo el de efectuar una serie de reflexiones generales, centrándonos un poco más sobre una cuestión descuidada por el sector doctrinal como han sido los Anexos del Protocolo.
La Unión Europea ante la emergencia climática
2020
From its origins, the Member States of the European Union (EU) have demonstrated the need for strategic energy measures. As it did with the 1952 Coal and Steel Treaty and the 1957 Euratom Treaty, designing a strong economic area, although it was based on the promotion of a decadent and unsustainable energy. Today, we are facing an EU, which climate policy is far from the original one, with a plausible objective: to give priority to energy efficiency while making its own path through the international community, designing key, competitive and sustainable measures, contributing significantly to the new international climate regime under the Paris Agreement. However the adoption of the Eu…
Validation of intensive care unit-acquired infection surveillance in the Italian SPIN-UTI network
2010
Validity is one of the most critical factors concerning surveillance of nosocomial infections (NIs). This article describes the first validation study of the Italian Nosocomial Infections Surveillance in Intensive Care Units (ICUs) project (SPIN-UTI) surveillance data. The objective was to validate infection data and thus to determine the sensitivity, specificity, and positive and negative predictive values of NI data reported on patients in the ICUs participating in the SPIN-UTI network. A validation study was performed at the end of the surveillance period. All medical records including all clinical and laboratory data were reviewed retrospectively by the trained physicians of the validat…
Sensor-Oriented Passive RFID
2010
This chapter addresses the design of new UHF tag antennas for sensing applications able to host detectors and additional electronics but also to act as passive sensor itself for some modification of the target. Starting from the consideration that the tag is both a digital and an analog device, sensing data may be achieved without using microcontrollers by a simple signal processing of the tag response and of the turn-on power. The chapter is particularly focused on the monitoring of human body features even if the proposed ideas and devices, here demonstrated by simulations and experimentation, may also be applied in a variety of scenarios.