Search results for "Provocation test"

Deep inspiration-induced bronchoprotection is stronger than bronchodilation

2000

We have previously shown that in healthy subjects, deep inspiration (DI) has not only a bronchodilatory but also a bronchoprotective effect that is absent in asthmatic subjects. We conducted the study reported here to test the hypothesis that the bronchoprotective effect is stronger than the bronchodilatory effect, and to determine the extent to which these two effects are related. Ten healthy subjects underwent provocations in which single doses of methacholine, previously shown to reduce FEV(1) by 10% to 20% (Dose 1) and by 20% to 40% (Dose 2) were administered after a 20-min period devoid of DI. To measure the bronchodilator effect, DIs were performed immediately after the first spiromet…

A simple method of bronchoprovocation using a valved holding chamber.

2004

This study was undertaken to ascertain whether the use of a valved holding chamber (VHC) during bronchial provocation testing might increase lung deposition and repeatability of the test relative to the tidal breathing method. The 2-min tidal breathing results were compared to five inhalations from a VHC device in patients using the Pari-provoII nebulizer (MMD = 2.1mkm). Lung and mouth deposition, losses though the exhaled air and losses before aerosol delivery to the patient's mouth were measured in patients using a radiolabeled 99Tc-DTPA solution and gamma camera. The study revealed that lung deposition was 67% with the VHC method, and losses with exhaled air were 29% of the inhaled amoun…

[Nasal and bronchial provocation with allergen in patients with mild asthma and allergic rhinitis -- similarities and differences].

2005

Nasal provocation testing as an international standard for evaluation of allergic and nonallergic rhinitis.

2005

Standardized nasal provocation testing (NPT) has been shown to be a safe and very useful tool in the diagnosis of allergic and nonallergic rhinitis. However, in the United States, its use has been mostly limited to scientific investigations, and it has not yet been widely accepted as a standard diagnostic procedure in clinical practice. NPT aims to identify and quantify the clinical relevance of inhalant allergens or occupational irritants. During NPT, nasal respiratory mucosa is exposed to an airborne substance suspected to cause symptoms in the respective individual. Clinical reactions are monitored in a controlled and standardized fashion. Nasal secretions, symptoms such as itching, snee…

The airway response to deep inspirations decreases with COPD severity and is associated with airway distensibility assessed by computed tomography.

2008

In patients with mild chronic obstructive pulmonary disease (COPD), the effect of deep inspirations (DIs) to reverse methacholine-induced bronchoconstriction is largely attenuated. In this study, we tested the hypothesis that the effectiveness of DI is reduced with increasing disease severity and that this is associated with a reduction in the ability of DI to distend the airways. Fifteen subjects [Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage I–II: n = 7; GOLD stage III–IV: n = 8] underwent methacholine bronchoprovocation in the absence of DI, followed by DI. The effectiveness of DI was assessed by their ability to improve inspiratory vital capacity and forced expira…

Monitoring response to treatment in asthma management: food for thought

2004

Asthma is a chronic inflammatory disorder of the airways that is characterized by episodic symptoms. In this regard, asthma management has classically involved periodic re-assessment by the health-care provider, during which therapy is altered mainly based on clinical and physiological parameters, such as assessment of symptoms, spirometry and peak expiratory flow monitoring. In this context, various markers of airway inflammation (e.g. eosinophils in the induced sputum, nitric oxide in the exhaled air) have been proposed to assess the severity of asthma and to adjust the therapy accordingly. The evaluation of airway hyper-responsiveness with different stimuli has also been suggested as a n…

Effetti di un programma di esercizio fisico sul grado di reattività bronchiale negli asmatici

2012

EFFETTI DI UN PROGRAMMA DI ESERCIZIO FISICO SUL GRADO DI REATTIVITÀ BRONCHIALE NEGLI ASMATICI N. Scichilone 1, G. Morici 2, D. Zangla 3, R. Arrigo 1, I. Cardillo 1, V. Bellia 1, M.R. Bonsignore 1 1 DIBIMIS, Università degli Studi di Palermo, 2 BIONEC, Università degli Studi di Palermo, 3 DISMOT, Università degli Studi di Palermo SCOPO DEL LAVORO: Il nostro gruppo ha recentemente dimostrato che il grado di reattività bronchiale in assenza di respiri profondi si riduce negli individui sani in seguito ad un intenso programma di allenamento. Nello studio corrente, abbiamo valutato se un simile effetto benefico dell’esercizio fisico potesse realizzarsi negli asmatici. MATERIALI E METODI: Nove as…

Automatic Conjunctival Provocation Test Using Hough Transform of Extended Canny Edge Maps

2013

Computer-aided diagnosis is developed for assessment of allergic rhinitis/rhinoconjunctivitis measuring the relative redness of sclera under application of allergen solution. The patient’s eye images are taken from commercial digital camera. The iris is robustly localized using a gradient-based Hough circle transform. From the center of the pupil, the region of interest within the sclera is extracted using geometric anatomybased a-priori information. The red color pixels are extracted thresholding in the hue, saturation and value color space. Then, redness is measured by taking mean of saturation projected into zero hue. Evaluation is performed with 92 images taken from 13 subjects, 8 respo…

How Can We Assess the Perception of Induced Dyspnea in Chronic Obstructive Pulmonary Disease?

2004

Objective TO evaluate various methods for studying the perception of dyspnea in chronic obstructive pulmonary disease (COPD) using a new parameter, the change in Borg scale rating, and others already in use: the linear regression slope and the application of Stevens' law to the response-perception curve-ie change in forced expiratory volume in 1 second (ΔFEV 1 )-change in dyspnea (Adyspnea). Patients and method A bronchial challenge test was performed on 70 patients with stable COPD and no contraindications for performing the test (European Respiratory Society criteria), during which dyspnea was measured (Borg scale) after each nebulization. Perception was analyzed using: a ) the linear reg…

Effects of topical treatment with the raft modulator miltefosine and clobetasol in cutaneous mastocytosis: a randomized, double-blind, placebo-contro…

2009

Background Mastocytosis is characterized by the accumulation and activation of mast cells in different organs, most commonly the skin. Miltefosine, a raft modulator, has recently been shown to inhibit the activation of mast cells and to reduce mast cell-driven skin inflammatory responses. Objectives To study the safety and efficacy of topical miltefosine treatment of skin lesions in patients with mastocytosis. Methods Thirty-nine adult patients with mastocytosis with skin involvement were treated in a double-blind, placebo-controlled, parallel trial with topical miltefosine and clobetasol for 2 weeks. Treatment areas were analysed for changes in skin lesions and symptoms following mechanica…