Search results for "Proximal"
showing 10 items of 100 documents
The little finger ulnar palmar digital artery perforator flap: anatomical basis.
2013
PURPOSE: The aim of this study was to explore the cutaneous vascularization of the hypothenar region and investigate the anatomical basis for perforator propeller flaps for coverage of the flexor aspect of the little finger. METHODS: The area between the pisiform and the base of the little finger was studied in 14 hands of fresh cadavers injected with red latex. An oval flap 1.5 cm large was raised along the axis between these two points. Perforators going into the flap were dissected up to their origin from the ulnar palmar digital artery of the little finger, and their distance from the proximal edge of the A1 pulley was recorded. RESULTS: The mean number of perforator arteries entering t…
Influence of Different DXA Acquisition Modes on Monitoring the Changes in Bone Mineral Density After Hip Resurfacing Arthroplasty
2011
Dual-energy X-ray absorptiometry (DXA) is a technique enabling the measurement of bone mineral density (BMD) around prostheses after hip resurfacing arthroplasty (HRA). In this study, we evaluated the consistency of different DXA acquisition modes with 33 patients who had undergone HRA. Patients were scanned with DXA immediately after surgery and at 3-, 6-, and 12-mo time points. All the patients were scanned with dual femur and orthopedic hip acquisition modes and analyzed using 10-region ROI model. With both acquisition modes, a statistically significant decrease (p0.05, Wilcoxon's test) in BMD at 3mo was revealed in 3 ROIs, located to upper and lateral upper femur. Both acquisition modes…
Vertical osteoconductivity and early bone formation of titanium-zirconium and titanium implants in a subperiosteal rabbit animal model.
2013
Objectives The aim of this pilot study was to evaluate the vertical osteoconductive and osteointegrative dynamics around titanium–zirconium (TiZr) implants compared to titanium (Ti) implants. Materials and methods In a split-leg design, 12 TiZr-SLActive and 12 Ti-SLActive implants were inserted 3 mm above bone level in the proximal tibia of 12 rabbits. Full periosteal flaps were repositioned to cover the site. Specimens were obtained after 10, 20 and 30 days (each n = 4 per group). Histomorphometric measurements included percentage of linear bone fill (PLF; %), new marginal vertical bone height (VBH; mm) and vertical bone-to-implant contact (vBIC; %). Statistical analysis was performed with…
Least-Norm Regularization For Weak Two-Level Optimization Problems
1992
In this paper, we consider a regularization for weak two-level optimization problems by adaptation of the method presented by Solohovic (1970). Existence and approximation results are given in the case in which the constraints to the lower level problems are described by a multifunction. Convergence results for the least-norm regularization under perturbations are also presented.
Best Proximity Points for Some Classes of Proximal Contractions
2013
Given a self-mapping g: A → A and a non-self-mapping T: A → B, the aim of this work is to provide sufficient conditions for the existence of a unique point x ∈ A, called g-best proximity point, which satisfies d g x, T x = d A, B. In so doing, we provide a useful answer for the resolution of the nonlinear programming problem of globally minimizing the real valued function x → d g x, T x, thereby getting an optimal approximate solution to the equation T x = g x. An iterative algorithm is also presented to compute a solution of such problems. Our results generalize a result due to Rhoades (2001) and hence such results provide an extension of Banach's contraction principle to the case of non-s…
Caki-1 cells as a model system for the interaction of renally secreted drugs with OCT3.
2008
<i>Background/Aims:</i> Organic cation transporters (OCT) in the proximal tubules (PTs) participate in the renal secretion of several therapeutic agents. The exact role of OCT3 in renal secretion remains undetermined, partially due to the lack of an appropriate in vitro model system. The current work introduces the PT representative cell line, Caki-1, as a model system for studying the involvement of OCT3 in renal secretion. <i>Methods:</i> Caki-1 cells were characterized for OCT3 expression via real-time RT-PCR and immunocytochemical staining techniques. Uptake kinetics of OCT3 in Caki-1 cells was determined using prototypical substrates and inhibitors. Inhibition o…
COULD STUDY AND PLAY OF CHESS IMPROVE SOCIAL INTERACTIONS? RE PORT OF AN ITALIAN CASE STUDY.
2012
Aim of this work is to improve the social interactions within a math classrooms (6 th grade), introducing a chess activity during the curricula hours. The theoretical framework upon which this research is based consists of: Vygotsky’s Theory of child developmen t (Vygotsky, 1986), the knowledge objectification theory (Radford, 2006) and theory of configural concepts (a personal review of Fischbein’s theory of figural concepts). We will discuss the results of an experimentation that has the purpose to create an appropriate environment wher e the students develop the abilities to solve and pose problems.
OCTN2-Mediated Carnitine Uptake in a Newly Discovered Human Proximal Tubule Cell Line (Caki-1)
2006
The proximal tubular reabsorption of carnitine in the human kidney is significant because more than 95% of the carnitine filtered in the kidney is reabsorbed by the proximal tubules therefore maintaining the homeostatic balance of carnitine in the body. Objectives of this study include the characterization of OCTN2 function in the Caki-1 cell line and the potential interactions of carnitine uptake with renally secreted drugs, including drugs of quaternary ammonium structure. Caki-1 cells were additionally characterized to be of proximal tubule nature, and an apical membrane expression pattern of OCTN2 in Caki-1 cells was discovered. Uptake studies with radiolabeled L-carnitine in Caki-1 cel…
Caki-1 Cells Represent an in vitro Model System for Studying the Human Proximal Tubule Epithelium
2007
<i>Background/Aims:</i> The human proximal tubule (PT) epithelium is distinguished from other nephron segments via several unique characteristics. Studies assessing PT epithelium increasingly employ cell lines, bypassing the complexity of primary cell cultures. However, few human model systems exist for studying PT cells in vitro. The current work involves an intensive characterization of Caki-1 cells, a commercially available human renal cell line. <i>Methods:</i> Caki-1 cells were validated as a representative model system for PT cell research via morphological, physiological and biochemical investigations including light and transmission electron microscopy, trans…
Use of flow cytometry and confocal microscopy techniques to investigate early CdCl(2)-induced nephrotoxicity in vitro.
2001
CdCl(2) is a well-known toxic compound for the kidney in vivo and in vitro. We report here part of the results of an ECVAM (European Centre for the Validation of Alternative Methods) contract study, aimed at establishing and assessing several flow cytometric and confocal microscopic endpoints for use in an in vitro nephrotoxicity model. Three renal tubule cell lines, OK (opossum, proximal tubule origin), LLC-PK1 (pig, proximal tubule origin) and MDCK (dog, distal tubule origin) were exposed for 1, 5 and 24 h to 25 microM and 100 microM CdCl(2). The results obtained for mitochondrial membrane potential showed a decrease in all the cell lines after 5 h of treatment with both CdCl(2) concentra…