Search results for "Pseudomonas Aeruginosa"
showing 10 items of 158 documents
Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections.
2017
The influence of vitamin D3 and its metabolites calcifediol (25(OH)D) and calcitriol on immune regulation and inflammation is well described, and raises the question of potential benefit against bacterial infections. In the current study, 25(OH)D was encapsulated in liposomes to enable aerosolisation, and tested for the ability to prevent pulmonary infection by Pseudomonas aeruginosa. Prepared 25(OH)D-loaded liposomes were nanosized and monodisperse, with a negative surface charge and a 25(OH)D entrapment efficiency of approximately 23%. Jet nebulisation of liposomes was seen to yield an aerosol suitable for tracheo-bronchial deposition. Interestingly, 25(OH)D in either liposomes or ethanol…
Auswirkungen eines neuen Wassersystems auf nosokomiale Kolonisierung oder Infektion mit Pseudomonas aeruginosa
2016
Aim: We aimed to study the impact of new water systems, which were less contaminated with P. aeruginosa, on the incidence of healthcare-associated P. aeruginosa cases (colonizations or infections) in care units that moved to a different building between 2005 and 2014. Methods: Generalized Estimated Equations were used to compare the incidence of P. aeruginosa healthcare-associated cases according to the building. Results: Twenty-nine units moved during the study period and 2,759 cases occurred in these units. No difference was observed when the new building was compared with older buildings overall. Conclusion: Our results did not support our hypothesis of a positive association between wat…
Detection of temporal clusters of health care-associated infections or colonizations with Pseudomonas aeruginosa.
2016
International audience; We investigated temporal clusters of Pseudomonas aeruginosa cases between 2005 and 2014 in 1 French university hospital, overall and by ward, using the Kulldorff method. Clusters of positive water samples were also investigated at the whole hospital level. Our results suggest that water outlets are not closely involved in the occurrence of clusters of P aeruginosa cases.
The antimicrobial activity of honey and propolis extracts from the central region of Romania
2021
Abstract Honey and propolis from Apis mellifera (bees) are products that have been used due to their multiple biological properties. The antimicrobial activity of 10 honey samples of known origin and 4 propolis extracts gathered from the same beekeepers located in Transylvania, Romania, were used against certain microorganisms: Escherichia coli, Staphylococcus aureus, Bacillus cereus, Pseudomonas aeruginosa and Candida albicans. The study also investigated the positive interaction of propolis aqueous extracts when used with poly-floral honey against the same microorganisms. The most sensitive to the activity of honey samples was the S. aureus strain (the largest inhibition area 18 mm) for p…
Biofilm-detached cells, a transition from a sessile to a planktonic phenotype: a comparative study of adhesion and physiological characteristics in P…
2008
Pseudomonas aeruginosa is a pathogenic bacterium widely investigated for its high incidence in clinical environments and its ability to form strong biofilms. During biofilm development, sessile cells acquire physiological characteristics differentiating them from planktonic cells. But after treatment with disinfectants, or to ensure survival of the species in hostile environments, biofilm cells can detach. This complicates disinfection procedures. This study aimed to physiologically characterize cells detached from a P. aeruginosa biofilm and to compare them with their sessile and planktonic counterparts. We first tested planktonic growth kinetics and capacities to form new biofilms. Then w…
Evaluation of the antibacterial power and biocompatibility of zinc oxide nanorods decorated graphene nanoplatelets: New perspectives for antibiodeter…
2017
Background Nanotechnologies are currently revolutionizing the world around us, improving the quality of our lives thanks to a multitude of applications in several areas including the environmental preservation, with the biodeterioration phenomenon representing one of the major concerns. Results In this study, an innovative nanomaterial consisting of graphene nanoplatelets decorated by zinc oxide nanorods (ZNGs) was tested for the ability to inhibit two different pathogens belonging to bacterial genera frequently associated with nosocomial infections as well as biodeterioration phenomenon: the Gram-positive Staphylococcus aureus and the Gram-negative Pseudomonas aeruginosa. A time- and dose-…
Epidemiología molecular y genómica de aislados resistentes de Pseudomonas aeruginosa de origen hospitalario.
2019
Pseudomonas aeruginosa es un patógeno frecuente en entornos hospitalarios que acumula multitud de resistencias a antibióticos. Ante la dificultad de encontrar tratamiento efectivo, los pacientes están mucho tiempo colonizados y aumenta la probabilidad de transmisión. El principal objetivo del presente trabajo ha sido mostrar cómo el estudio evolutivo a nivel de genomas completos puede ser útil para la detección de transmisiones a diferentes niveles. Se decidió aplicar la misma metodología de reconstrucción de la filogenia a partir de las variantes encontradas en genomas completos que además se dataron por métodos bayesianos. Para ello, hemos contado con muestras de P. aeruginosa multirresis…
A Difficult Case of Necrotizing Fasciitis Caused By Acinetobacter baumannii
2010
This study reports the case of a 55-year-old woman with diabetes with a necrotizing fasciitis of the right lower limb and the perineum, first admitted at the emergency department for septic shock with cardiac arrest, and later transferred to the department of surgery. Microbiological and histopathological examination confirmed the diagnosis of necrotizing fasciitis caused by Acinetobacter baumanii. A broad-spectrum antibiotic therapy was administered and later readjusted according to the results of microbiological culture. Intensive hemodynamic support was required. Wounds were dressed daily with a 3 percent boric acid solution and a silver sulfadiazine-impregnated dressing. An extensive s…
Biofilmas un metallo-β-laktamāzes producēšanas noteikšana Pseudomonas aeruginosa un Acinetobacter baumannii baktēriju almos
2020
Pseudomonas aeruginosa un Acinetobacter baumannii metallo-β-laktamāžu producēšana ir kļuvusi par pieaugošu terapeitisko problēmu visā pasaulē, kā arī antibiotiku rezistentiem celmiem ir spēja veidot noturīgākas biofilmas, kas rada problēmas šo patogēnu izraisīto infekciju ārstēšanā. Darba mērķis: noteikt Pseudomonas aeruginosa un Acinetobacter baumannii spēju veidot biofilmas, producēt metallo- β-laktamāzes, kā arī statistiski apkopot datus par jutību pret antibakteriālajiem līdzekļiem starp 2017. gadu un 2019. gadu, un veikt rezistences izmaiņas salīdzinājumu. Uzdevumi: identificēt no elpceļiem iegūtos izolātus ar BBL™ Crystal™ sistēmu, kā arī ar GenoType® BC gramnegative testu, veikt anti…
Drug resistance patterns of bacteria isolated from patients with nosocomial pneumonia at Tehran hospitals during 2009-2011
2013
Introduction: Nosocomial pneumonia remains an important cause of mortality and morbidity worldwide. Surveillance programs play an important role in the identification of common etiologic agents and local patterns of antimicrobial resistance. Methodology: In this study we determined the frequency and antimicrobial susceptibility of pathogens isolated from patients with nosocomial pneumonia during 2009 to 2011. Results: A total of 642 bacteria were isolated from 516 suspected samples. Acinetobacter baumannii (21.1%, n = 136), was the commonest isolated pathogen followed by Pseudomonas aeruginosa (17.4%, n = 112) , Staphylococcus aureus (15.8%, n = 102) and enterococci (8.4% n = 54). The most …