Search results for "Psoriasis."
showing 10 items of 191 documents
Traditional medicine as a source of new therapeutic agents against psoriasis.
2000
In the frame of traditional medicine, the use in the treatment of psoriasis of some plants typical of the flora of Sicily is reported. A preliminary search on some plants used for the treatment of psoriasis in Asia, South America and Africa is also reported.
Presystemic metabolism and intestinal absorption of antipsoriatic fumaric acid esters.
2003
Psoriasis is a chronic inflammatory skin disease. Its treatment is based on the inhibition of proliferation of epidermal cells and interference in the inflammatory process. A new systemic antipsoriasis drug, which consists of dimethylfumarate and ethylhydrogenfumarate in the form of their calcium, magnesium and zinc salts has been introduced in Europe with successful results. In the present study, a homologous series of mono- and diesters of fumaric acid has been studied with respect to the sites and kinetics of presystemic ester degradation using pancreas extract, intestinal perfusate, intestinal homogenate and liver S9 fraction. In addition, intestinal permeability has been determined usi…
Polycystin-1 downregulation induces ERK-dependent mTOR pathway activation in a cellular model of psoriasis
2018
Psoriatic plaques tend to localize to the knees and elbows, areas that are particularly subject to mechanical stress resulting from bending and friction. Moreover, plaques often develop at sites of mechanical trauma or injury (Koebner phenomenon). Nevertheless, mechanotransduction has never been linked to psoriasis. Polycystins (polycystin-1, PC1; polycystin-2, PC2) are mechanosensitive molecules that function as key regulators of cellular mechanosensitivity and mechanotransduction. The aim of this in vitro study was to investigate the role of polycystins in the development of psoriasis. We showed that PC1 knockdown in HaCaT cells led to an elevated mRNA expression of psoriasis-related biom…
On the genetics of psoriasis
1974
To elucidate the mode of inheritance in psoriasis, Falconer's model for estimating heritability which is under the assumption of multifactorial inheritance, was applied to the data of Hellgren (1967) from Sweden. The heritability estimates were based on both manifest and potential psoriasis since a clear separation of these two categories was impossible. These estimates were 64% for parents, 60% for siblings and 52% for all first degree relatives which included the children of psoriatic cases. For second degree relatives it was 48%. None of these differences are statistically significant. The results are discussed.
Untersuchungen �ber den Hemmfaktor der Phosphoglucose-Isomerase in Erythrocyten von Kranken mit florider Psoriasis vulgaris
1967
Die Untersuchungen uber Herkunft und Beschaffenheit des Hemmkorpers der PGI von Kranken mit florider Psoriasis vulgaris haben ergeben, das es sich um ein nur in der Zelle, in diesem Falle im Erythrocyten, nicht aber im Serum solcher Kranker vorliegendes Protein handelt.
Zur Aktivit�t der Phosphoglucose-Isomerase im Serum und der Acetylcholinesterase in Serum und Erythrocyten von Kranken mit florider Psoriasis vulgaris
1967
Es wurde bei Kranken mit florider Psoriasis vulgaris und Kontrollpersonen die Phosphoglucose-Isomerase im Serum, sowie die Acetylcholinesterase in Serum und Erythrocyten bestimmt. Wahrend die Phosphoglucose-Isomerase eine deutliche Aktivitatssteigerung im Serum solcher Kranken aufweist, lagen die Aktivitaten der Acetylcholinesterase in Serum und Erythrocyten im Normbereich. Die Phosphoglucose-Isomerase-Erhohung wahrend der floriden Phase bei der Psoriasis vulgaris wird als ein vermehrtes Ausstromen von Zellenzymen in das Serum moglicherweise aus einer Vielzahl von Organen interpretiert. Der Mechanismus fur diesen Vorgang ist noch weitgehend unbekannt. Jedoch scheint hierbei eine Beteiligung…
Mangiferin glycethosomes as a new potential adjuvant for the treatment of psoriasis
2020
[EN] Mangiferin, a natural compound isolated from Mangifera indica L, was incorporated in glycerosomes, ethosomes and alternatively in glycerol-ethanol phospholipid vesicles (glycethosomes). Actually, only glycethosomes were able to stably incorporate the mangiferin that was loaded at increasing concentrations (2, 4, 6, 8 mg/mL). The morphology, size distribution, rheological properties, surface charge and entrapment efficiency of prepared vesicles were deeply measured. All vesicles were mainly spherical, oligolamellar, small in size (similar to 145 nm) and negatively charged (similar to-40 mV), as confirmed by cryo-TEM observation and dynamic laser light scattering measurements. The higher…
Differences between the Glycosylation Patterns of Haptoglobin Isolated from Skin Scales and Plasma of Psoriatic Patients
2012
Improved diagnosis of psoriasis, by new biomarkers, is required for evaluating the progression rate of the disease and the response to treatment. Haptoglobin (Hpt), a glycoprotein secreted by hepatocytes and other types of cells including keratinocytes, was found with glycan changes in psoriasis and other diseases. We previously reported that Hpt isolated from plasma of psoriatic patients is more fucosylated than Hpt of healthy subjects. The aim of this study was to compare the glycosylation pattern of Hpt isolated from skin scales or plasma of patients with psoriasis with that of Hpt from cornified epidermal layer or plasma of healthy subjects. High performance liquid chromatography analys…
�ber das Vorkommen der Glucose-6-Phosphat-Dehydrogenase im Blutserum von Psoriasis vulgaris-Kranken
1963
ImBlutserum von 48Psoriasis vulgaris-Kranken konnte, weitgehend in Abhangigkeit von der Ausdehnung und Akuitat der Hauterscheinungen, eineErhohung derGlucose-6-Phosphat-Dehydrogenase nachgewiesen werden. Dieser Befund wird vergleichend mit den Ergebnissen bei Gesunden und anderen Hautkranken diskutiert und als psoriasistypisches, nicht aber psoriasisspezifisches Phanomen gewertet, fur dessen Zustandekommen auf Grund der bisherigen Untersuchungen eine Erklarung nicht gegeben werden kann, wenngleich im Hinblick auf das Vorkommen von Pentosen in pathologisch veranderter Psoriasis-Haut zu diesem, den Pentose-Cyclus einleitenden Enzym eine hypothetische Verbindung gegeben scheint.
Psoriasis moderada-grave en pacientes pediátricos y jóvenes: experiencia en el registro BIOBADADERM
2022
Resumen {0>El debut de la psoriasis en la edad pediatrica, aunque generalmente leve, puede requerir tratamiento sistemico en las formas moderadas o graves de la enfermedad. Childhood-onset psoriasis generally follows an indolent course but patients with moderate or severe disease may require systemic treatment. El objetivo de este trabajo es analizar la frecuencia relativa, las caracteristicas de los pacientes, el tratamiento empleado y los eventos adversos (EA) observados a partir del registro BIOBADADERM en ninos y jovenes con psoriasis moderada-grave. The aim of this study was to determine the relative proportion of children and young people aged up to 21 years with moderate to severe ps…