Search results for "Pulmonary function test"
showing 10 items of 116 documents
Genome-wide association analysis identifies six new loci associated with forced vital capacity
2014
Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P <5 x 10(-8)) with FVC in or near EFEMP1, BMP6, MIR129-2-HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispani…
Respiratory Effects of Exposure to Traffic-Related Air Pollutants During Exercise
2020
Traffic-related air pollution (TRAP) is increasing worldwide. Habitual physical activity is known to prevent cardiorespiratory diseases and mortality, but whether exposure to TRAP during exercise affects respiratory health is still uncertain. Exercise causes inflammatory changes in the airways, and its interaction with the effects of TRAP or ozone might be detrimental, for both athletes exercising outdoor and urban active commuters. In this Mini-Review, we summarize the literature on the effects of exposure to TRAP and/or ozone during exercise on lung function, respiratory symptoms, performance, and biomarkers. Ozone negatively affected pulmonary function after exercise, especially after co…
Clinical and economic consequences of switching from omalizumab to mepolizumab in uncontrolled severe eosinophilic asthma
2021
AbstractSevere asthma is burdened by frequent exacerbations and use of oral corticosteroids (OCS), which worsen patients’ health and increase healthcare spending. The aim of this study was to assess the clinical and economic impact of switching from omalizumab (OMA) to mepolizumab (MEP) in patients eligible for both biologics, but not optimally controlled by omalizumab. We retrospectively enrolled uncontrolled severe asthmatic patients who switched from OMA to MEP during the last two years. Information included blood eosinophil count, asthma control test (ACT), spirometry, serum IgE, fractional exhaled nitric oxide (FeNO), OCS intake, drugs, exacerbations/hospitalizations, visits and diagno…
3 He-MRI-based vs. conventional determination of lung volumes in patients after unilateral lung transplantation: a new approach to regional spirometry
2002
Background: To use 3Helium (3He)-MRI in patients with unilateral lung grafts to assess the contributions of graft and native lung to total ventilated lung volume, and second to compare conventional measurements of intrapulmonary gas volume (spirometry, body plethysmography) with image-based volumetry of ventilated lung parenchyma visualized by hyperpolarized 3He-MRI. Methods: With Ethics Committee approval, five patients with single lung transplantation (SLTX) for idiopathic pulmonary fibrosis (IPF) underwent both conventional pulmonary function testing (PFT) and 3He-MRI of the lung. Intrapulmonary gas volume (GV) during the inspiratory breathhold for 3He-MRI was calculated from measured fu…
666 Pulmonary Abnormalities in Children and Adolescents with Type 1 Diabetes Mellitus
2012
Background and Aims Few studies are available on pulmonary function abnormalities in children with diabetes with controversial results. Spirometric abnormalities and reduction of lung diffusing capacity for carbon monoxide (DLCO) have been reported. A cross sectional study was designed to assess whether children and adolescents with type 1 diabetes have pulmonary dysfunction. Methods Spirometry measurements were performed and DLCO was measured. The final data analysis was conducted on 57 diabetics (mean age 14.4 + 3.09 years, 31 males) and 40 healthy controls (mean age 13.6 + 2.2 years, 19 males). Results Although FVC, FEV1, FEV1/FVC of diabetics were lower than in control, significant stat…
Measuring lung function in asthmatic children: A spirometry and forced oscillation technique (FOT) comparison
2016
Background: Spirometry is the most common pulmonary function test used in asthma diagnosing. However, it requires good patient co-operation. FOT has gained increasing attention for the measurement of pulmonary function in children because it is performed at steady state breathing. Aim: To compare spirometry and FOT in order to discriminate severity of asthma according to GINA. Methods: Spirometry and FOT were performed in 176 out-patient asthmatic children (5-16 year), 100 (57%) with naive Persistent Asthma (PA) and 76 (43%) with Intermittent Asthma (IA), consecutively enrolled at the IBIM pediatric clinic. Two principal component analyses (PCA) were performed, the first (PCA1) based on FEV…
Performance of Radiomics Features in the Quantification of Idiopathic Pulmonary Fibrosis from HRCT.
2020
Background: Our study assesses the diagnostic value of different features extracted from high resolution computed tomography (HRCT) images of patients with idiopathic pulmonary fibrosis. These features are investigated over a range of HRCT lung volume measurements (in Hounsfield Units) for which no prior study has yet been published. In particular, we provide a comparison of their diagnostic value at different Hounsfield Unit (HU) thresholds, including corresponding pulmonary functional tests. Methods: We consider thirty-two patients retrospectively for whom both HRCT examinations and spirometry tests were available. First, we analyse the HRCT histogram to extract quantitative lung fibrosis…
Relationship Between Patient-Reported Outcomes and Clinical Outcomes in Patients With Morquio A Syndrome
2019
Abstract This cross-sectional analysis assessed the correlation between patient-reported outcomes (PROs) and clinical outcomes in 24 German patients with Morquio A. Clinical outcomes included 6-minute walk test (6MWT), 3-minute stair climb (3MSC) test, and joint range of motion as measures for endurance/mobility, forced vital capacity (FVC) and maximum voluntary ventilation (MVV) as measures for respiratory function, and height as an important manifestation. The PROs included the EuroQoL (EQ) 5D-5L (EQ5D-5L), to measure health-related QoL (HRQoL), and patients’ rating of their ability to walk, climb, or breathe. In adults, endurance and pulmonary function measures and height showed strong a…
The Flow-Volume-Measurement in Computer-Supported Lung Function Analysis
1982
For some years computers have been applied more and more in pulmonary function laboratories. On the one hand the medico-technical industry could connect older diagnostic systems with new calculators, on the other hand completely computerised lung function desks have been developed.
The Severe Asthma Registry – German data
2018
Patients with severe persistent asthma represent the highest unmet medical need among the asthmatic population. To improve the understanding of underlying mechanisms and disease progression the German Asthma Net (GAN, www.german-asthma-net.de) launched a Severe Asthma Registry in December 2011. Enrolled patients undergo detailed clinical and physiologic evaluations, including patients’ medical history, allergy and lung function tests, blood analyses as well as past and concomitant medication and comorbidities. Patients are followed up every year. As of February 2018, 1097 subjects were recruited in Germany, Austria, and Slovenia. The mean age±SEM of the 839 German adult patients is 50.6±0.5…