Search results for "Pyran"

showing 10 items of 224 documents

CCDC 1557895: Experimental Crystal Structure Determination

2020

Related Article: Luka Ðorđević, Cataldo Valentini, Nicola Demitri, Cécile Mézière, Magali Allain, Marc Sallé, Andrea Folli, Damien Murphy, Samuel Mañas-Valero, Eugenio Coronado, Davide Bonifazi|2020|Angew.Chem.,Int.Ed.|59|4106|doi:10.1002/anie.201914025

3813-tri-t-butyl[1]benzopyrano[4'3'2':110]phenanthro[345-mnab]xanthene dibromomethane solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1555938: Experimental Crystal Structure Determination

2018

Related Article: Sun Li, Xiang-Yu Chen, Qiang Liu, Anssi Peuronen, Kari Rissanen, Dieter Enders|2017|Synthesis|49|4861|doi:10.1055/s-0036-1588509

3-benzyl-4-(4-methoxyphenyl)-2-oxo-6-phenyl-34-dihydro-2H-pyran-5-carbonitrileSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 173857: Experimental Crystal Structure Determination

2002

Related Article: G.Rajsekhar, C.P.Rao, P.K.Saarenketo, E.Kolehmainen, K.Rissanen|2002|Carbohydr.Res.|337|187|doi:10.1016/S0008-6215(01)00311-1

46-O-Butylidene-N-(o-chlorophenyl)-beta-D-glucopyranosylamineSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 2144108: Experimental Crystal Structure Determination

2022

Related Article: Natalina Makieieva, Teobald Kupka, Grzegorz Spaleniak, Oimahmad Rahmonov, Agata Marek, Alfred Błażytko, Leszek Stobiński, Nataliya Stadnytska, Danuta Pentak, Aneta Buczek, Małgorzata A. Broda, Piotr Kuś, Joachim Kusz, Maria Książek|2022|Struct.Chem.|33|2133|doi:10.1007/s11224-022-02026-7

4-oxo-4H-pyran-26-dicarboxylic acid methanol solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1968536: Experimental Crystal Structure Determination

2021

Related Article: Ni Putu Ariantari, Marian Frank, Ying Gao, Fabian Stuhldreier, Anna-Lene Kiffe-Delf, Rudolf Hartmann, Simon-Patrick Höfert, Christoph Janiak, Sebastian Wesselborg, Werner E.G. Müller, Rainer Kalscheuer, Zhen Liu, Peter Proksch|2021|Tetrahedron|85|132065|doi:10.1016/j.tet.2021.132065

6-(3-hydroxybutan-2-yl)-5-(hydroxymethyl)-4-methoxy-2H-pyran-2-oneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1989940: Experimental Crystal Structure Determination

2021

Related Article: Alvaro Sanz-Vidal, Daniel Gaviña, Lia Sotorríos, Enrique Gómez-Bengoa, Fernando López Ortiz, María Sánchez-Roselló, Carlos del Pozo|2021|Chem.Commun.|57|8023|doi:10.1039/D1CC03161A

7-phenyl-9-(trifluoromethyl)-6H-dibenzo[bd]pyranSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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Construction of a genetically modified wine yeast strain expressing the Aspergillus aculeatus rhaA gene, encoding an -L-Rhamnosidase of enological in…

2003

Monoterpenes such as geraniol, linalool, and -terpineol present in grapes determine the varietal flavor properties of young quality wines made from Muscat varieties (for reviews, see references 19 and 21). Geraniol and linalool are considered to be the most important of the monoterpene alcohols, as they are present in greater concentrations and have lower flavor thresholds than other major wine monoterpenes. In particular, linalool is thought to be responsible for the grapelike aroma of wines produced from the Muscat variety. A large proportion of

AFSG Stafafdelingen (WUATV)Glycoside HydrolasespurificationAcyclic MonoterpenesMonoterpenepurifying glycosidasesWineSaccharomyces cerevisiaeMicrobiologyApplied Microbiology and Biotechnologychemistry.chemical_compoundLinalooll-rhamnopyranosidaseMicrobiologieVitisFood scienceFlavorVLAGAlpha-L-rhamnosidasel-arabinofuranosidaseWineEcologybiologybeta-GlucosidaseAspergillus aculeatusbeta-d-glucopyranosidasefood and beveragesbiology.organism_classificationAFSG Staff Departments (WUATV)Yeast in winemakingAspergillusBiochemistrychemistryaromaFermentationMonoterpenesFood Microbiologymicrovinification processessaccharomyces-cerevisiaeGenetic EngineeringnigerGeraniolFood ScienceBiotechnologygrape juice
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Effects of nebivolol and atenolol on central aortic pressure in hypertensive patients: a multicenter, randomized, double-blind study.

2013

The main objective was to compare the mean change in augmentation index of hypertensive patients treated with nebivolol or atenolol.Multicenter, double-blind randomized study conducted in six Spanish centers. We enrolled outpatients between the ages of 40 and 65 years with mild or moderate essential hypertension (systolic blood pressure, SBP ≥ 140 mmHg to ≤ 179 mmHg and diastolic blood pressure, DBP ≥ 90 mmHg to ≤ 109 mmHg after a 2-week run-in placebo period). Patients received nebivolol 5 mg or atenolol 50 mg once daily. At week 3, atenolol could be titrated up to 100 mg qd for non-responders. Additionally, patients not achieving normal blood pressure after 6 weeks could be treated with 2…

AdultMalemedicine.medical_specialtyBlood PressureEssential hypertensionlaw.inventionNebivololHydrochlorothiazideRandomized controlled trialDouble-Blind MethodlawInternal medicineInternal MedicinemedicineHumansBenzopyransAntihypertensive AgentsAgedbusiness.industryGeneral MedicineMiddle AgedAtenololmedicine.diseaseNebivololPulse pressureBlood pressureAtenololEthanolaminesAnesthesiaHypertensionCardiologyAortic pressureFemaleEssential HypertensionCardiology and Cardiovascular Medicinebusinessmedicine.drugBlood pressure
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Effects of Nebivolol versus Carvedilol on Left Ventricular Function in Patients with Chronic Heart Failure and Reduced Left Ventricular Systolic Func…

2006

Beta-adrenoceptor antagonist (beta-blocker) therapy results in a significant improvement in left ventricular (LV) systolic function and prognosis in patients with chronic heart failure. Both carvedilol and nebivolol produce hemodynamic and clinical benefits in chronic heart failure, but it is unknown whether their peculiar pharmacologic properties produce different effects on LV function.To assess the effects on LV function of nebivolol compared with carvedilol in patients with chronic heart failure and reduced LV systolic function.Seventy patients with a LV ejection fractionor=40% and in New York Heart Association (NYHA) functional class II or III were randomly assigned to receive carvedil…

AdultMalemedicine.medical_specialtySystoleAdrenergic beta-AntagonistsCarbazolesHemodynamicsVentricular Function LeftNebivololPropanolaminesElectrocardiographyHeart RateInternal medicineHeart rateHumansMedicineBenzopyransPharmacology (medical)SystoleCarvedilolAgedHeart FailureEjection fractionmedicine.diagnostic_testbusiness.industryGeneral MedicineMiddle Agedmedicine.diseaseNebivololEthanolaminesHeart failureCardiologyCarvedilolFemaleCardiology and Cardiovascular MedicinebusinessElectrocardiographymedicine.drugAmerican Journal of Cardiovascular Drugs
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Synthesis of 2-Prenylated Alkoxylated Benzopyrans by Horner–Wadsworth–Emmons Olefination with PPARα/γ Agonist Activity

2021

[Image: see text] We have synthesized series of 2-prenylated benzopyrans as analogues of the natural polycerasoidol, a dual PPARα/γ agonist with anti-inflammatory effects. The prenylated side chain consists of five or nine carbons with an α-alkoxy-α,β-unsaturated ester moiety. Prenylation was introduced via the Grignard reaction, followed by Johnson–Claisen rearrangement, and the α-alkoxy-α,β-unsaturated ester moiety was introduced by the Horner–Wadsworth–Emmons reaction. Synthetic derivatives showed high efficacy to activate both hPPARα and hPPARγ as dual PPARα/γ agonists. These prenylated benzopyrans emerge as lead compounds potentially useful for preventing cardiometabolic diseases.

AgonistSynthetic derivatives[CHIM.ORGA]Chemical Sciences/Organic chemistry010405 organic chemistrymedicine.drug_classStereochemistryOrganic ChemistryHorner–Wadsworth–Emmons reactionGrignard reaction01 natural sciencesBiochemistry0104 chemical sciences3. Good health010404 medicinal & biomolecular chemistrychemistry.chemical_compoundchemistryPrenylationDrug DiscoverySide chainmedicinePPARα/γ activityMoietyPrenylated benzopyransHorner-Wadsworth-Emmons reactionBenzopyransACS Medicinal Chemistry Letters
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