Search results for "Pyrimidine"
showing 10 items of 589 documents
CCDC 696697: Experimental Crystal Structure Determination
2009
Related Article: D.Visinescu, L.M.Toma, O.Fabelo, C.Ruiz-Perez, F.Lloret, M.Julve|2009|Polyhedron|28|851|doi:10.1016/j.poly.2008.12.032
Enantioseparation of nuarimol by affinity electrokinetic chromatography-partial filling technique using human serum albumin as chiral selector
2008
The present paper deals with the enantiomeric separation of nuarimol enantiomers by affinity EKC-partial filling technique using HSA as chiral selector. Firstly, a study of nuarimol interactions with HSA by CE-frontal analysis was performed. The binding parameters obtained for the first site of interaction were n(1) = 0.84; K(1) = 9.7 +/- 0.3x10(3 )M(-1) and the protein binding percentage of nuarimol at physiological concentration of HSA was 75.2 +/- 0.2%. Due to the moderate affinity of nuarimol towards HSA the possibility of using this protein as chiral selector for the separation of nuarimol using the partial filling technique was evaluated. A multivariate optimization approach of the mo…
The experimental herbicide UKJ72J is an inhibitor of succinate oxidation in plant mitochondria
1983
not received UKJ72J Herbicide Thiopyrimidine Plant mitochondria Inhibitor Succinate oxidation
Protective effect of trehalose-loaded liposomes against UVB-induced photodamage in human keratinocytes
2014
Trehalose, a naturally occurring non-reducing disaccharide, is known to act as a major protein stabilizer that can reduce ultraviolet B (UVB)-induced corneal damage when topically applied to the eye. However, due to the low skin permeability of trehalose, which makes the development of topical formulations difficult, its use as a skin photoprotective agent has been limited. Previous findings demonstrated that liposomes may significantly improve the intracellular delivery of trehalose. Therefore, the present study aimed to assess the protective effects of trehalose-loaded liposomes against UVB-induced photodamage using the immortalized human keratinocyte cell line, HaCaT. The effects were al…
Complete-active-space second-order perturbation theory (CASPT2//CASSCF) study of the dissociative electron attachment in canonical DNA nucleobases ca…
2015
Low-energy (0-3 eV) ballistic electrons originated during the irradiation of biological material can interact with DNA/RNA nucleobases yielding transient-anion species which undergo decompositions. Since the discovery that these reactions can eventually lead to strand breaking of the DNA chains, great efforts have been dedicated to their study. The main fragmentation at the 0-3 eV energy range is the ejection of a hydrogen atom from the specific nitrogen positions. In the present study, the methodological approach introduced in a previous work on uracil [I. González-Ramírez et al., J. Chem. Theory Comput. 8, 2769-2776 (2012)] is employed to study the DNA canonical nucleobases fragmentations…
Characterization of variations responsible for neurodevelopmental disorders in the PTBP1 and PTBP2 genes
2022
Heterogeneous nuclear ribonucleoproteins (hnRNPs) polypyrimidine tract-binding protein 1 and 2 (PTBP1 and PTBP2) are splicing regulators, shuttling between nucleus and cytoplasm thanks to the action of partially overlapping nuclear localization and export signals (NLS and NES respectively). These two paralog proteins share similar RNA binding properties although they exhibit different expression levels and kinetics, post-translational modifications and cofactor interactions across tissues and cell types, thus regulating RNA metabolism in a cell- specific manner. Despite their fundamental role as alternative splicing factors implicated in cell growth, neuronal cell differentiation, and immun…
Photoinduced DNA Lesions in Dormant Bacteria. The Peculiar Route Leading to Spore Photoproduct Unraveled by Multiscale Molecular Dynamics
2020
Some bacterial species enter a dormant state in the form of spores to resist to unfavorable external conditions. Spores are resistant to a wide series of stress agents, including UV radiation, and can last for tens to hundreds of years. Due to the suspension of biological functions such as DNA repair, they accumulate DNA damage upon exposure to UV radiation. Differently from active organisms, the most common DNA photoproduct in spores are not cyclobutane pyrimidine dimers, but rather the so-called spore photoproduct. This non-canonical photochemistry results from the dry state of DNA and the binding to small acid soluble proteins that drastically modify the structure and photoreactivity of …
CCDC 1039720: Experimental Crystal Structure Determination
2015
Related Article: Nadia Marino, Donatella Armentano, Giovanni De Munno, Francesc Lloret, Joan Cano, Miguel Julve|2015|Dalton Trans.|44|11040|doi:10.1039/C5DT00553A
CCDC 1839829: Experimental Crystal Structure Determination
2018
Related Article: Gustavo Portalone, Kari Rissanen|2018|Cryst.Growth Des.|18|5904|doi:10.1021/acs.cgd.8b00662
CCDC 1839828: Experimental Crystal Structure Determination
2018
Related Article: Gustavo Portalone, Kari Rissanen|2018|Cryst.Growth Des.|18|5904|doi:10.1021/acs.cgd.8b00662