Search results for "Pyrimidine"
showing 10 items of 589 documents
CCDC 249686: Experimental Crystal Structure Determination
2005
Related Article: V.Niel, A.L.Thompson, A.E.Goeta, C.Enachescu, A.Hauser, A.Galet, M.C.Munoz, J.A.Real|2005|Chem.-Eur.J.|11|2047|doi:10.1002/chem.200400930
CCDC 249688: Experimental Crystal Structure Determination
2005
Related Article: V.Niel, A.L.Thompson, A.E.Goeta, C.Enachescu, A.Hauser, A.Galet, M.C.Munoz, J.A.Real|2005|Chem.-Eur.J.|11|2047|doi:10.1002/chem.200400930
CCDC 249689: Experimental Crystal Structure Determination
2005
Related Article: V.Niel, A.L.Thompson, A.E.Goeta, C.Enachescu, A.Hauser, A.Galet, M.C.Munoz, J.A.Real|2005|Chem.-Eur.J.|11|2047|doi:10.1002/chem.200400930
CCDC 249687: Experimental Crystal Structure Determination
2005
Related Article: V.Niel, A.L.Thompson, A.E.Goeta, C.Enachescu, A.Hauser, A.Galet, M.C.Munoz, J.A.Real|2005|Chem.-Eur.J.|11|2047|doi:10.1002/chem.200400930
CCDC 987580: Experimental Crystal Structure Determination
2014
Related Article: Isabel Castro, M. Luisa Calatayud, Wdeson P. Barros, José Carranza, Miguel Julve, Francesc Lloret, Nadia Marino, and Giovanni De Munno|2014|Inorg.Chem.|53|5759|doi:10.1021/ic500544n
CCDC 297276: Experimental Crystal Structure Determination
2006
Related Article: J.Pasan, J.Sanchiz, C.Ruiz-Perez, J.Campo, F.Lloret, M.Julve|2006|Chem.Commun.||2857|doi:10.1039/b602144a
Design, Synthesis and Biological Evaluation of Novel Pyrazolo[1,2,4]triazolopyrimidine Derivatives as Potential Anticancer Agents
2021
Three novel pyrazolo-[4,3-e][1,2,4]triazolopyrimidine derivatives (1, 2, and 3) were designed, synthesized, and evaluated for their in vitro biological activity. All three compounds exhibited different levels of cytotoxicity against cervical and breast cancer cell lines. However, compound 1 showed the best antiproliferative activity against all tested tumor cell lines, including HCC1937 and HeLa cells, which express high levels of wild-type epidermal growth factor receptor (EGFR). Western blot analyses demonstrated that compound 1 inhibited the activation of EGFR, protein kinase B (Akt), and extracellular signal-regulated kinase (Erk)1/2 in breast and cervical cancer cells at concentrations…
EFFECTS OF SENSITIZED AND UNSENSITIZED LONGWAVE U.V.-IRRADIATION ON THE SOLUTION PROPERTIES OF DNA
1971
— Two types of photoreactions occur in DNA irradiated in aqueous systems with longwave u.v.-light (Λ > 295 nm), namely, (a) thymine dimerization, and (b) single- and double-strand breakage of the sugar phosphate backbone; these two reactions are unrelated. The presence of acetophenone as a photosensitizer caused an increase in dimerization by a factor of 16, and an increase in single-strand breaks by a factor of 4. The number of thymine dimers per single-strand break is about 100 in the sensitized and 25 in the unsensitized reaction. The alteration of the radius of gyration of DNA molecules is that expected by the degradation observed. At the same time the change in hyperchromicity is very …
Retro-Diels-Alder Protocol for the Synthesis of Pyrrolo[1,2-a]pyrimidine and Pyrimido[2,1-a]isoindole Enantiomers
2013
A simple protocol was introduced to prepare several enantiomerically pure heterocycles by using (–)-(1R,2R,3S,4S)-3-aminonorbornene-2-carboxylic acid as a chiral auxiliary. The protocol is based on a domino ring-closure reaction, in which the relative configuration of the new asymmetric center is controlled by the stereochemistry of the amino acid, followed by a microwave-induced retro-Diels–Alder reaction.
2-Acylamino- and 2,4-bis(acylamino)pyrimidines as supramolecular synthons analysed by multiple non-covalent interactions. DFT, X-ray diffraction, and…
2012
Intermolecular interactions of ten 2-acylamino and 2,4-bis(acylamino)pyrimidines (7 of which are previously unknown) have been investigated by X-ray structural, quantum chemical (DFT), and NMR spectral methods. Especially the concentration dependencies of the (1)H NMR chemical shifts and titrations with other molecules capable of multiple hydrogen bonding provided useful information regarding their association via triple or quadruple hydrogen bonding, which is controlled by the conformational preferences of 2-acylamino- and 2,4-bis(acylamino)pyrimidines. On comparison of the properties of 2-acylamino- and 2,4-bis(acylamino)pyrimidines with the corresponding pyridines, an additional nitrogen…