Search results for "Q1"
showing 10 items of 447 documents
Delineating a new critical region for juvenile myoclonic epilepsy at the 22q11.2 chromosome.
2013
No abstract available
Quantitative real-time PCR with SYBR Green detection to assess gene duplication in insects: study of gene dosage in Drosophila melanogaster (Diptera)…
2011
Abstract Background The accurate determination of the number of copies of a gene in the genome (gene dosage) is essential for a number of genetic analyses. Quantitative real time PCR (qPCR) with TaqMan detection has shown advantages over traditional Southern-blot and FISH techniques, however the high costs of the required labeled probes is an important limitation of this method. qPCR with SYBR Green I detection is a simple and inexpensive alternative, but it has never been applied to the determination of the copy number of low copy number genes in organisms with high allelic variability (as some insects), where a very small margin of error is essential. Findings We have tested the suitabili…
Strategies to Reduce Oxidative Stress in Glaucoma Patients
2018
Background Primary open-angle glaucoma (POAG) is a multifactorial pathology involving a variety of pathogenic mechanisms, including oxidative/nitrosative stress. This latter is the consequence of the imbalance between excessive formation and insufficient protection against reactive oxygen/nitrogen species. Objective Our main goal is to gather molecular information to better managing pathologic variants that may determine the individual susceptibility to oxidative/nitrosative stress (OS/NS) and POAG. Method An extensive search of the scientific literature was conducted using PUBMED, the Web of Science, the Cochrane Library, and other references on the topic of POAG and OS/NS from human and a…
Integrating digital documents by means of concept maps: testing an intervention program with eye-movements modelling examples
2021
When using the Internet to learn about a curricular topic students face the challenge of not only understanding each single document, but also of integrating the ideas in a combined representation. Several intervention studies have tested instructional methods, such as building concept maps, aimed at teaching integration of multiple documents to Secondary education and older students. However, building a concept map may be demanding for learners and requires competencies to build maps in an appropriate way. In the current study we explore the extent to which such integration processes relying a concept map mapping instruction can be efficiently taught to 6th grade students. Specifically, we…
Application of an innovative alignment optimisation method to a cross-cultural mean comparison of teacher self-efficacy: A cross-country study
2021
Teacher self-efficacy is a crucial personal characteristic that is important not only for teachers’ well-being but also for the overall teaching and learning. However, the difficulty to ascertain scalar invariance in the measurement of the construct has beset previous attempts of cross-cultural comparisons. This study implements an alignment optimisation method to compare and rank mean teacher self-efficacy of over 150,000 teachers across 48 countries and economies that participated in the Teaching and Learning International Survey (TALIS) that was conducted 2018. The findings show that Columbia, Portugal, United Arab Emirates, Hungary, and South Africa have teachers with the highest mean s…
The role of exercise on peripheral nerve regeneration: from animal model to clinical application
2021
Peripheral nerve injury is a complex condition with a variety of signs and symptoms depending on the severity and nerves involved. Peripheral nerve damage may lead to sensory and motor functions deficits and even lifelong disability, causing important socioeconomic costs worldwide. Despite the increase in knowledge of the mechanisms of injury and regeneration, a full functional recovery is still unsatisfying in the majority of patients. It is well known that exercise promotes physical and psychological well-being, by ameliorating general health. In the last years, there has been a growing interest in evaluating the effects of exercise on the peripheral nervous system. Experimental works wit…
Lower secondary school pupils’ written descriptions of their experiences with bullying and the tendency to seek help
2021
The purpose of this study was to examine lower secondary school students’ (n = 223) descriptions of bullying and their experiences with the phenomenon. Students at three schools in Norway completed a survey containing open-ended questions. We employed a mixed-methods analytical approach in which responses were coded thematically and then quantified. Findings indicate that students viewed bullying in a manner consistent with prevalent definitions in the literature. However, they were often unsure whether social conflicts they had experienced would be considered bullying. School was clearly featured as the primary arena for bullying, although bullying in free-time activities and on social med…
Meta-Analysis of Mitochondrial DNA Reveals Several Population Bottlenecks during Worldwide Migrations of Cattle
2014
Several studies have investigated the differentiation of mitochondrial DNA in Eurasian, African and American cattle as well as archaeological bovine material. A global survey of these studies shows that haplogroup distributions are more stable in time than in space. All major migrations of cattle have shifted the haplogroup distributions considerably with a reduction of the number of haplogroups and/or an expansion of haplotypes that are rare or absent in the ancestral populations. The most extreme case is the almost exclusive colonization of Africa by the T1 haplogroup, which is rare in Southwest Asian cattle. In contrast, ancient samples invariably show continuity with present-day cattle …
El auto sacramental y la alegorización de la historia: "El socorro de Cádiz" de Juan Pérez de Montalbán
2012
Este trabajo estudia la relación excepcional entre acontecimientos históricos y género sacramental, a partir de un auto que se dio por perdido durante bastantes años. Se trata de El socorro de Cádiz de Juan Pérez de Montalbán en el que se alegoriza la defensa de Cádiz contra los ingleses en 1625. This paper analyzes the exceptional relationship between historical events and the sacramental genre, based on an «auto» that was considered lost during many years. This «auto» is El socorro de Cádiz by Juan Pérez de Montalbán, in which the playwright allegorizes the defense of Cádiz against the English in 1625.
La esclava del cielo, Santa Engracia, una comedia olvidada de Andrés de Claramonte
2009
La esclava del cielo, Santa Engracia, a forgotten play by Andrés de Claramonte Two are the objectives of this paper: in the first place, to elucidate the relationship that exists between the manuscript copy that has been preserved of a play entitled La esclava del cielo, Santa Engracia and the play of the same title that is mentioned in several documents of the 17th Century related to the professional companies of the autores Cristóbal Ortiz, Juan Bautista Valenciano and Juan Jerónimo Valenciano. In the second place, to critically analyze the attribution of La esclava del cielo, Santa Engracia to the playwright Andrés de Claramonte that appears in several of these documents, both by assessi…