Search results for "QM"
showing 10 items of 284 documents
Effects of conversation content on viewing dyadic conversations
2016
People typically follow conversations closely with their gaze. We asked whether this viewing is influenced by what is actually said in the conversation and by the viewer’s psychological condition. We recorded the eye movements of healthy (N = 16) and depressed (N = 25) participants while they were viewing video clips. Each video showed two people, each speaking one line of dialogue about socio-emotionally important (i.e., personal) or unimportant topics (matter-of-fact). Between the spoken lines, the viewers made more saccadic shifts between the discussants, and looked more at the second speaker, in personal vs. matter-of-fact conversations. Higher depression scores were correlated with les…
Glucose 6-P dehydrogenase delays the onset of frailty by protecting against muscle damage.
2021
Background: Frailty is a major age-associated syndrome leading to disability. Oxidative damage plays a significant role in the promotion of frailty. The cellular antioxidant system relies on reduced nicotinamide adenine dinucleotide phosphate (NADPH) that is highly dependent on glucose 6-P dehydrogenase (G6PD). The G6PD-overexpressing mouse (G6PD-Tg) is protected against metabolic stresses. Our aim was to examine whether this protection delays frailty. Methods: Old wild-type (WT) and G6PD-Tg mice were evaluated longitudinally in terms of frailty. Indirect calorimetry, transcriptomic profile, and different skeletal muscle quality markers and muscle regenerative capacity were also investigate…
No paradox, no progress: inverse cancer comorbidity in people with other complex diseases.
2011
Salvador Martínez [et al.]. 5 p., 2 tables and references.
Comparison of elbow flexor isokinetic peak torque and fatigue index between men and women of different training level
2017
The purpose of the study was to compare elbow flexion peak torque (PT) and fatigue index (FI) during isokinetic concentric contractions in men and women with different training levels. Sixty-eight young men and women were divided into four groups: resistance trained men (RTM), non-resistance trained men (NRTM), resistance trained women (RTW) and non- resistance trained women (NRTW). Participants performed two tests on an isokinetic dynamometer, one to evaluate PT and one to evaluate FI. Significant interactions were found for sex and resistance training status with both PT and FI. In general, resistance-trained subjects had higher PT, and women showed lower PT than men. PT values were 67.12…
Need to evaluate the performance of real-time PCR assays for the quantitation of cytomegalovirus DNA load in lower respiratory tract specimens
2013
There is an increasing appreciation for the potential clinical value of the quantitation of cytomegalovirus (CMV) DNA in the lower respiratory tract in critically ill patients lacking canonical immunosuppression, in view of the possible pathogenic role of CMV in these patients [1]. No data have been published on the analytical performance of real-time PCR assays for this purpose. We present our data on the performance of the COBAS® AmpliPrep/COBAS® TaqMan CMV PCR Assay (Roche Diagnostics, Mannheim, Germany) for the quantitation of CMV DNA in tracheal aspirates (TA). This CMV PCR assay has been approved recently by the US Food and Drug Administration for use with plasma specimens [2]. We cho…
Expression of Human Ubiquitous Aquaporins in Chorial Villus Samples
2011
Background/objectives: Aquaporins (AQPs) are a family of proteins (AQP0-12) ubiquitously expressed acting as cell membrane water channels. AQP 1/3/8/9 expression has been found in human placenta and fetal membranes; however, AQP4 is the only identified in first trimester fetal tissue samples. We aimed to determine AQP mRNA expression in first trimester of pregnancy and compare it to the expression in placenta at delivery. Material and Methods: 26 Chorionic villus (CV) samples and 5 placental samples were collected and analyzed by real time-PCR using Taqman assay (Applied Biosystems®) for human AQP1, 2, 3, 4, 5, 6, 7, 8, 9, 11 and 18S. Results: CV expressed high mRNA levels of AQP1, 3, 9 and…
Perinatal high-fat diet increases hippocampal vulnerability to the adverse effects of subsequent high-fat feeding
2015
Epidemiological observations report an increase in fat consumption associated with low intake of n-3 relative to n-6 polyunsaturated fatty acids (PUFAs) in women of childbearing age. However, the impact of these maternal feeding habits on cognitive function in the offspring is unknown. This study aims to investigate the impact of early exposure to a high-fat diet (HFD) with an unbalanced n-6/n-3 PUFAs ratio on hippocampal function in adult rats. Furthermore, we explored the effects of perinatal HFD combined with exposure to HFD after weaning. Dams were fed a control diet (C, 12% of energy from lipids, n-6/n-3 PUFAs ratio: 5) or HFD (HF, 39% of energy from lipids, n-6/n-3 PUFAs ratio: 39) th…
Regulation data for the horizontal jump of children and adolescents
2021
The Horizontal Jump (HJ) is a daily tool that could be used to categorize the level of muscle fitness performance of the lower limbs. The goal was to compare the muscle fitness with those of international studies and to propose percentiles to assess the HJ performance of children and adolescents. A cross-sectional study was conducted. A total number of 3023 children and adolescents between the ages of 6.0 to 17.9 were studied. Weight, height, waist circumference (WC), and lower limb muscle fitness were evaluated. The student HJ performance values in Chile were inferior when compared to HJ performance in Brazil, Poland and Europe. For the Greek study, differences occurred only from age 6 to …
Acute oral administration of low doses of methylphenidate targets calretinin neurons in the rat septal area.
2015
Methylphenidate (MPD) is a commonly administered drug to treat children suffering from attention deficit hyperactivity disorder (ADHD). Alterations in septal driven hippocampal theta rhythm may underlie attention deficits observed in these patients. Amongst others, the septo-hippocampal connections have long been acknowledged to be important in preserving hippocampal function. Thus, we wanted to ascertain if methylphenidate administration, which improves attention in patients, could affect septal areas connecting with hippocampus. We used low and orally administered methylphenidate doses (1.3; 2.7 and 5mg/Kg) to rats what mimics the dosage range in humans. In our model, we observed no effec…
Transient hypothyroidism during lactation arrests myelination in the anterior commissure of rats. A magnetic resonance image and electron microscope …
2018
Thyroid hormone deficiency at early postnatal ages affects the cytoarchitecture and function of neocortical and telencephalic limbic areas, leading to impaired associative memory and in a wide spectrum of neurological and mental diseases. Neocortical areas project interhemispheric axons mostly through the corpus callosum and to a lesser extent through the anterior commissure (AC), while limbic areas mostly project through the AC and hippocampal commissures. Functional magnetic resonance data from children with late diagnosed congenital hypothyroidism and abnormal verbal memory processing, suggest altered ipsilateral and contralateral telencephalic connections. Gestational hypothyroidism aff…