Search results for "QRDR"

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Spread of Klebsiella pneumoniae ST395 non-susceptible to carbapenems and resistant to fluoroquinolones in North-Eastern France

2017

Abstract Objectives Fluoroquinolones (FQs) are a potential treatment for infections caused by extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae that are susceptible to these agents. Methods Owing to increasing non-susceptibility to carbapenems among Enterobacteriaceae, in this study FQ resistance mechanisms were characterised in 36 ertapenem-non-susceptible Klebsiella pneumoniae isolated from North-Eastern France in 2012. The population structure was described by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). Results Among the 36 isolates, 13 (36%) carried a carbapenemase encoding-gene. Decreased expression of the OmpK35-encoding gene might be…

0301 basic medicineMicrobiology (medical)QRDRCarbapenemST395Klebsiella pneumoniaeR Factors030106 microbiologyImmunologyMicrobial Sensitivity Tests[ SDV.MP.BAC ] Life Sciences [q-bio]/Microbiology and Parasitology/BacteriologyMicrobiologybeta-LactamasesMicrobiologyPMQR03 medical and health scienceschemistry.chemical_compoundPlasmid[ SDV.MP ] Life Sciences [q-bio]/Microbiology and ParasitologyDrug Resistance Multiple BacterialmedicinePulsed-field gel electrophoresisHumansImmunology and AllergyCarbapenemComputingMilieux_MISCELLANEOUSbiologychlorhexidinebiology.organism_classificationmedicine.diseaseEnterobacteriaceaeVirology[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/BacteriologyAnti-Bacterial AgentsKlebsiella Infections3. Good healthKlebsiella pneumoniae[SDV.MP]Life Sciences [q-bio]/Microbiology and ParasitologyCarbapenemschemistryMultilocus sequence typingFranceKlebsiella pneumoniaErtapenemFluoroquinolonesMultilocus Sequence TypingPlasmidsmedicine.drugMLST
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