Search results for "QS"
showing 10 items of 127 documents
Inside c-kit tyrosine kinase: molecular modeling and QSAR in the search of new inhibitors
2010
The strategic use of One Nation as a symbol during PMQs from J. Major to T. May
2023
One Nation, as a conceptual construct which started to develop since the 19th century has often been associated with the Conservative Party’s politics regarding their effort to bridge the gap between “the two nations” (the underprivileged and the well-off members of society) and in the elevation of the condition of the people in the UK (a requisite for social harmony). Most recent conservative Prime Ministers have been eager to present their own version of the One Nation tradition based on their views of the role the state should play (either limited or extended state intervention). David Seawright explains that these conflicting stances are not expressed in a strict polarisation within the…
Study of the aryl hydrocarbon receptor mediated effects through in silico modeling and in vitro bioassays
2020
The aryl hydrocarbon receptor (AhR) is a cytoplasmatic sensor of diverse endogenous and exogenous substances. In a toxicological context, the former known as “dioxin receptor” has been investigated as a xenobiotic chemoreceptor and due to its roles in mediating carcinogenesis, endocrine disruption, among other immunological, hepatic, cardiovascular, and dermal toxicity mechanisms. The deep physiological implications of AhR in cellular proliferation, adhesion, division, differentiation, as well as in the reproductive, immunological and cardiovascular homeostasis have opened a new field of research in order to harness AhR’s pharmacological potential. Hence, AhR has become a therapeutic target…
Identificación de GRHL2 como biomarcador epigenético en la resistencia a terapias anti-EGFR en el cáncer de pulmón no microcítico
2023
El cáncer de pulmón (CP) es la principal causa de fallecimiento por cáncer en todo el mundo, debido principalmente a la detección tardía de la enfermedad y la carencia de terapias efectivas. Pese al avance en los últimos años de las terapias dirigidas, como los inhibidores tirosina quinasa (ITQs) de EGFR de primera y segunda generación (erlotinib y gefitinib), que han proporcionado un beneficio importante para un grupo de pacientes con CP no microcítico (CPNM) con mutaciones activadoras en EGFR, los pacientes han mostrado con el tiempo resistencia a los tratamientos debido a nuevas mutaciones en EGFR, como la mutación T790M. Inhibidores de tercera generación, como el osimertinib, superan es…
Le opere esposte da Maria Accascina alla Mostra d’Arte Sacra delle Madonie
2017
Il saggio espone i metodi e gli strumenti di ricerca utilizzati per la ricostruzione del catalogo della pioneristica Mostra D’Arte Sacra delle Madonie curata da Maria Accascina ed allestita nel 1937 presso il Convento dei PP. Riformati di Petralia Sottana, centro delle alte Madonie. Si tratta di più di quattrocento opere, tra gioielli, suppellettili liturgiche, oggetti preziosi di uso profano, coralli, paramenti sacri, tessuti, statue lignee, intagli, maioliche, tappeti, tele e tavole dipinte realizzate dal XI al XIX secolo. Le opere, alcune delle quali perdute, provengono dalle collezioni nobiliari, dall’allora Museo Nazionale di Palermo, ora Galleria Regionale della Sicilia, Palazzo Abate…
Uzņēmuma klientu pārvaldības sistēmas pilnveidošana
2019
“Uzņēmuma klientu pārvaldības sistēmas pilnveidošana” ietver klientu pārvaldības sistēmas uzlabojumus ar tās integrāciju ziņapmaiņas vietnē “Slack”. Izmantojot “Slack” komandas, uzņēmuma darbinieki var ātri, ērti un uzskatāmi iegūt informāciju vai veikt darbības, kuru veikšanai iepriekš būtu nepieciešama programmēšanas inženieru iejaukšanās. Uzņēmuma klientu daudzumam strauji augot, radās nepieciešamība pēc rīka, kas ļautu veikt šīs darbības arī bez tehniskām zināšanām. Programmatūra ir izstrādāta ar Python 2, lietojot Tornado ietvaru. Ziņojumu uzglabāšana notiek ar AWS SQS.
Application of Molecular Topology for the Prediction of Reaction Yields and Anti-Inflammatory Activity of Heterocyclic Amidine Derivatives
2011
Topological-mathematical models based on multiple linear regression analyses have been built to predict the reaction yields and the anti-inflammatory activity of a set of heterocylic amidine derivatives, synthesized under environmental friendly conditions, using microwave irradiation. Two models with three variables each were selected. The models were validated by cross-validation and randomization tests. The final outcome demonstrates a good agreement between the predicted and experimental results, confirming the robustness of the method. These models also enabled the screening of virtual libraries for new amidine derivatives predicted to show higher values of reaction yields and anti-infl…
L’attaque verbale : norme discursive et culturelle pendant les Prime Minister’s Questions
2023
La culture parlementaire du parlement britannique à Westminster est façonnée par des coutumes, des traditions, des rites et des conventions facilement reconnaissables, notamment lors des questions au Premier ministre (Prime Minister’s Questions ou PMQ). Le débat, en tant qu’activité inhérente au parlement, fait du discours parlementaire une caractéristique de cette culture. La prise de parole des députés, soumise aux règles et aux normes très formelles de la Chambre, sont censées, selon le guide de bonne conduite, Erskine May, refléter les caractéristiques du langage parlementaire telles que « la bonne humeur et la modération » (E. May 2019). De telles règles ne semblent pas superflues au r…