Search results for "R1"
showing 6 items of 1016 documents
Systematic Comparison of Epidemic and Non-Epidemic Carbapenem Resistant Klebsiella pneumoniae Strains
2021
Over the past few decades, extensively drug resistant (XDR) resistant Klebsiella pneumoniae has become a notable burden to healthcare all over the world. Especially carbapenemase-producing strains are problematic due to their capability to withstand even last resort antibiotics. Some sequence types (STs) of K. pneumoniae are significantly more prevalent in hospital settings in comparison to other equally resistant strains. This provokes the question whether or not there are phenotypic characteristics that may render certain K. pneumoniae more suitable for epidemic dispersal between patients, hospitals, and different environments. In this study, we selected seven epidemic and non-epidemic ca…
IgA-Dominant Infection-Associated Glomerulonephritis Following SARS-CoV-2 Infection
2021
The renal involvement of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported. The etiology of kidney injury appears to be tubular, mainly due to the expression of angiotensin-converting enzyme 2, the key joint receptor for SARS-CoV-2; however, cases with glomerular implication have also been documented. The multifactorial origin of this renal involvement could include virus-mediated injury, cytokine storm, angiotensin II pathway activation, complement dysregulation, hyper-coagulation, and microangiopathy. We present the renal histological findings from a patient who developed acute kidney injury and de novo nephrotic syndrome, highly suggestive of acute IgA-domina…
The interplay between the host microbiome and pathogenic viral infections
2021
The microorganisms associated with an organism, the microbiome, have a strong and wide impact in their host biology. In particular, the microbiome modulates both the host defense responses and immunity, thus influencing the fate of infections by pathogens. Indeed, this immune modulation and/or interaction with pathogenic viruses can be essential to define the outcome of viral infections. Understanding the interplay between the microbiome and pathogenic viruses opens future venues to fight viral infections and enhance the efficacy of antiviral therapies. An increasing number of researchers are focusing on microbiome-virus interactions, studying diverse combinations of microbial communities, …
Quantitative microscopy reveals stepwise alteration of chromatin structure during herpesvirus infection
2019
During lytic herpes simplex virus 1 (HSV-1) infection, the expansion of the viral replication compartments leads to an enrichment of the host chromatin in the peripheral nucleoplasm. We have shown previously that HSV-1 infection induces the formation of channels through the compacted peripheral chromatin. Here, we used three-dimensional confocal and expansion microscopy, soft X-ray tomography, electron microscopy, and random walk simulations to analyze the kinetics of host chromatin redistribution and capsid localization relative to their egress site at the nuclear envelope. Our data demonstrated a gradual increase in chromatin marginalization, and the kinetics of chromatin smoothening arou…
Pyhäpäivien vietto varhaismodernin ajan Savossa (vuoteen 1710). Lectio praecursoria 29.4.2016.
2016
FM Miia Kuhan Suomen historian väitöskirja Pyhäpäivien vietto varhaismodernin ajan Savossa (vuoteen 1710) tarkastettiin 29.4.2016 Jyväskylän yliopistossa. Vastaväittäjänä toimi dosentti Raisa Maria Toivo Tampereen yliopistosta ja kustoksena professori Kustaa H. J. Vilkuna Jyväskylän yliopistosta.
Fonds structurels, effets de débordement géographique et croissance régionale en Europe.
2008
Les fonds structurels constituent l’un des instruments financiers de la politique regionale europeenne les plus intensement utilises afin de promouvoir la convergence entre les regions des pays membres de l’Union europeenne. Cependant, de nombreuses divergences theoriques et empiriques existent dans la litterature quant a leur capacite a encourager la croissance economique des regions les plus defavorisees. Par consequent, cet article se propose de proceder a des estimations complementaires en integrant des elements nouveaux : tout d’abord, nous adoptons une approche par l’econometrie spatiale afin de prendre en compte de possibles effets de debordement geographique entre regions ; ensuite,…