Search results for "R2"

Toll-like receptor 2 is dispensable for acquired host immune resistance to Candida albicans in a murine model of disseminated candidiasis

2004

Previous work by our group showed that Toll-like receptor 2 (TLR2) is essential for activation of innate immunity, playing a major role in the response of macrophages to Candida albicans, triggering cytokine and chemokine expression, and therefore TLR2 -/- mice are more susceptible to systemic primary candidiasis. In this work, we used a murine model of systemic C. albicans infection, in which resistance to reinfection with virulent wild-type cells is induced by prior exposure of mice to a low-virulence agerminative strain of C. albicans (primary sublethal infection), to study the influence of TLR2 gene deletion on (i) the ability to develop an acquired resistance upon vaccination; (ii) the…

Loss of circadian clock gene expression is associated with tumor progression in breast cancer

2014

Several studies suggest a link between circadian rhythm disturbances and tumorigenesis. However, the association between circadian clock genes and prognosis in breast cancer has not been systematically studied. Therefore, we examined the expression of 17 clock components in tumors from 766 node-negative breast cancer patients that were untreated in both neoadjuvant and adjuvant settings. In addition, their association with metastasis-free survival (MFS) and correlation to clinicopathological parameters were investigated. Aiming to estimate functionality of the clockwork, we studied clock gene expression relationships by correlation analysis. Higher expression of several clock genes (e.g., C…

Blow-up collocation solutions of nonlinear homogeneous Volterra integral equations

2011

In this paper, collocation methods are used for detecting blow-up solutions of nonlinear homogeneous Volterra-Hammerstein integral equations. To do this, we introduce the concept of "blow-up collocation solution" and analyze numerically some blow-up time estimates using collocation methods in particular examples where previous results about existence and uniqueness can be applied. Finally, we discuss the relationships between necessary conditions for blow-up of collocation solutions and exact solutions.

Informācijas sistēma izsoļu tiešsaistes vietnei

2019

Informācijas sistēma izsoļu tiešsaistes vietnei ir vietne kas piedāvā tās lietotājiem iespēju atlasīt un apskatīt eksistējošās izsoles sev vēlamajā kategorija – transports, nekustamie īpašumi, mantas u.c. Atsevišķiem lietotājiem iespēja izveidot, labot un dzēst izsoles. Vietne ir pielāgota lietošanai izmantojot interneta pārlūkprogrammu datorā vai planšetdatorā. Sistēma izstrādāta izmantojot Typescript (Angular2), C# un SQL datu bāzes izveidei, pārvaldībai un projekta vizualizāciia īstenota ar tīmekļa vietni un tika izmantots HTML un CSS.

Old World Megadroughts and Pluvials During the Common Era

2015

An atlas of megadroughts in Europe and in the Mediterranean Basin during the Common Era provides insights into climate variability.

RATIONAL DESIGN AND SYNTHESIS OF NOVEL INHIBITORS OF EPIGENETIC TARGET INVOLVED IN CANCER

2021

The effect of polytechnic reform on migration

2011

This paper examines the effect of the polytechnic reform on geographical mobility. A polytechnic, higher education reform took place in Finland in the 1990s. It gradually transformed former vocational colleges into polytechnics and also brought higher education to regions that did not have a university before. This expansion of higher education provides exogenous variation in the regional supply of higher education. The reform raised the mobility of high school graduates across local labour markets in the years after they had completed their secondary studies, which indicated increased mobility between high school and post-secondary education. We estimate that the reform enhanced the annual…

Urban segregation and unemployment: A case study of the urban area of Marseille – Aix-en-Provence (France)

2018

International audience; In this paper, we study the effects of the spatial organization of the urban area of Marseille – Aix-en-Provence on unemployment there. More specifically, differences in the characteristics of the residential population induce urban stratification with the result that urban structure may affect the probability of employment. In order to evaluate the effects of spatial structure on unemployment, we implement a spatial probit model to reveal the employment probabilities of young adults still living with their parents. Our results support the hypothesis that living in or near a deprived neighborhood decreases the probability of employment.

On-site Experimental Study of HCFC-22 Substitution with HFCs Refrigerants

2012

Abstract The European Regulation no 2037/2000 has banned manufacturing HCFC refrigerants from January 1st 2010, although its use is allowed up to 2015 if the fluids come from a recycling process. This situation creates the need for developing new working fluids to replace the HCFC in the refrigeration plants now in operation. Among all the HCFCs the R22 is the most widely used in a wide range of applications, especially in air conditioning. This paper presents the results of an experimental analysis comparing the performance of a vapour compression refrigerating unit operating with R22, and its performance in comparison to some HFCs fluids, substituting the former. In particular, the plant …

Experimental performance evaluation of a vapour compression refrigerating plant when replacing R22 with alternative refrigerants

2011

Abstract This paper presents the results of an experimental analysis comparing the performance of a vapour compression refrigerating unit operating with R22, and its performance in comparison to a new HFC fluid, substituting the former according to Regulation No 2037/2000. In particular, the plant working efficiency was first tested with R22 and then with three new HFC fluids: R417A, R422A and R422D. The investigation verified that despite the case of substitution and the advantage of being able to continue to use mineral oil as a lubricant in the compressor, the performance with the new tested fluids did not result as efficient as when using R22.