Search results for "R2"
showing 10 items of 285 documents
Dendritic Cell-Specific Deletion of β-Catenin Results in Fewer Regulatory T-Cells without Exacerbating Autoimmune Collagen-Induced Arthritis.
2015
Dendritic cells (DCs) are professional antigen presenting cells that have the dual ability to stimulate immunity and maintain tolerance. However, the signalling pathways mediating tolerogenic DC function in vivo remain largely unknown. The beta-catenin pathway has been suggested to promote a regulatory DC phenotype. The aim of this study was to unravel the role of beta-catenin signalling to control DC function in the autoimmune collagen-induced arthritis model (CIA). Deletion of beta-catenin specifically in DCs was achieved by crossing conditional knockout mice with a CD11c-Cre transgenic mouse line. Bone marrow-derived DCs (BMDCs) were generated and used to study the maturation profile of …
Role of PRRs (TLR2 and Dectin-1) in hematopoietic stem and progenitor cell differentiation: implications in protection against Candida albicans infec…
2020
Detection of infection by hematopoietic stem and progenitor cells (HSPCs) is essential to replace myeloid cells consumed during the immune response. HSPCs express some functional pattern recognition receptors involved in the recognition of Candida albicans. In this context, our group has previously demonstrated that C. albicans yeasts induce proliferation and differentiation of HSPCs via TLR2 and Dectin-1. In the present PhD thesis, we used in vitro and ex vivo models of HSPC differentiation to investigate the functional consequences for mature myeloid cells of exposure of HSPCs to PAMPs or C. albicans yeasts. In vitro experiments show that murine HSPCs continuously exposed to TLR2 or TLR4 …
Capacidad predictiva y pronóstica de factores moleculares en cáncer de mama HER2 positivo tratado con quimioterapia neoadyuvante basada en antracicli…
2017
El tratamiento neoadyuvante del cáncer de mama (CM) permite estudiar marcadores subrogados que puedan predecir respuesta clínica y supervivencia. La respuesta completa patológica (RCp) definida como la ausencia de tumor infiltrante en la mama y axila en la pieza quirúrgica se asocia a mejor supervivencia. En los tumores HER2 positivo el tratamiento de elección es la combinación de quimioterapia, antraciclinas y taxanos son los esquemas con mayor evidencia, con terapia anti-HER2 (trastuzumab (TTZ)) alcanzando tasas de RCp del 30-60%. No disponemos de factores predictivos que identifiquen qué subgrupo obtendrá mayores tasas de RCp . Existe evidencia que los tumores con receptores hormonales (…
Estudio del quark top en modelos de nueva física utilizando las infraestructuras Tier2 y Tier3 de Valencia
2011
25 páginas. Tesis de Máster de Física Avanzada del Departamento de Física Atómica, Molecular y Nuclear de la Universitat de Valencia. Fecha de lectura: 16 septiembre 2011.
Refined instability estimates for some inverse problems
2022
Many inverse problems are known to be ill-posed. The ill-posedness can be manifested by an instability estimate of exponential type, first derived by Mandache [29]. In this work, based on Mandache's idea, we refine the instability estimates for two inverse problems, including the inverse inclusion problem and the inverse scattering problem. Our aim is to derive explicitly the dependence of the instability estimates on key parameters. The first result of this work is to show how the instability depends on the depth of the hidden inclusion and the conductivity of the background medium. This work can be regarded as a counterpart of the depth-dependent and conductivity-dependent stability estim…
Preliminary data of oxidation kinetics of Fe2+Cr2O4 synthetic spinel
2010
Vizuālu semantisku vaicājumu izpilde pār relāciju datubāzēm
2021
Maģistra darba mērķis ir padziļināti izpētīt esošās metodes, rīkus un optimizācijas semantisko vaicājumu tulkošanai uz SQL un izpildei pār relāciju datubāzēm, un, veicot praktiskus eksperimentus, atrast galvenos cēloņus tam, kāpēc rīku ģenerētie vaicājumi nav optimāli. Vizuālu semantiska līmeņa (ontoloģijas izmantojošu) vaicājumu pār datiem veidošana var ļaut gala lietotājam tieši piekļūt ontoloģiju formā organizētiem datiem. Uz ontoloģijām balstīta piekļuve datiem piedāvā iespējas pārveidot semantiskus SPARQL vaicājumus par SQL vaicājumiem, kas var tikt izpildīti pār relāciju datubāzēm. Tomēr pieejamās tehnoloģijas, piemēram, rīks Ontop, atbalsta tikai ierobežotu vaicājumu klašu translācij…
Overcoming resistance to HER2 blockade in breast cancer: AXL as a promising druggable target and prognostic biomarker
2022
Introduction: Breast cancer is a heterogeneous disease consisting of uncontrolled growth of epithelial cells originating in the ducts or breast lobules. It is currently the most diagnosed cancer worldwide and the fifth cause of cancer-related death in general population, but the first cause in women. Breast cancer incidence is higher in developed countries due to increased risk factors and to increased and earlier detection by mammography screening, which considerably reduces mortality. This is the reason why transitioning countries have higher mortality despite having lower incidence. Regarding the origin of the disease, it is evidenced that the pathways implicated in normal development of…
Grūtniecības trauksme un uztvertais sociālais atbalsts
2021
Bakalaura darba mērķis bija noskaidrot saistību starp grūtniecības trauksmi un uztverto sociālo atbalstu un apskatīt sociāldemogrāfisko faktoru saistību ar trauksmes līmeni. Pētījumā piedalījās 318 pilngadīgas grūtnieces visos trijos grūtniecības trimestros. 11 respondentu dati netika analizēti, jo aptaujā uzrādīja, ka ultrasonogrāfisko izmeklējumu laikā konstatētas kādas grūtniecības komplikācijas. Pētījumam derīgie un izmantotie dati bija no 307 respondentēm, kas bija pilngadīgas grūtnieces vecumā no 18 līdz 45 gadiem ar vidējo vecumu M = 28,2. Pētījumā pielietotais instrumentārijs: 1) Demogrāfisko datu aptauja; 2) Daudzdimensionālā uztvertā sociālā atbalsta skala (Multidimensional scale …
Bi-2212 and Y123 highly curved single-crystal-like objects: whiskers, bows and ring-like structures
2012
High-temperature superconducting objects of Bi2Sr2CaCu2O8 and Y Ba2Cu3O7 highly curved in the ab-plane, such as curved/kinked whiskers, bows and ring-like structures, were obtained within a solid?liquid?solid (SLS) grass-like growth mechanism. As-grown objects are crystals with three-dimensional epitaxy similar to conventional single crystals: they can be viewed as crystal parts ?cut? from a conventional rectangular crystal. Between our curved objects and conventional crystals, whiskers or thin films there are some differences in the superconducting properties induced only by the shape factors and no new physics is observed. Some details of the growth mechanism are discussed, emphasizing cu…