Search results for "RAIL"
showing 10 items of 699 documents
TRAIL-R4 promotes tumor growth and resistance to apoptosis in cervical carcinoma HeLa cells through AKT.
2011
International audience; BACKGROUND: TRAIL/Apo2L is a pro-apoptotic ligand of the TNF family that engages the apoptotic machinery through two pro-apoptotic receptors, TRAIL-R1 and TRAIL-R2. This cell death program is tightly controlled by two antagonistic receptors, TRAIL-R3 and TRAIL-R4, both devoid of a functional death domain, an intracellular region of the receptor, required for the recruitment and the activation of initiator caspases. Upon TRAIL-binding, TRAIL-R4 forms a heteromeric complex with the agonistic receptor TRAIL-R2 leading to reduced caspase-8 activation and apoptosis. METHODOLOGY/PRINCIPAL FINDINGS: We provide evidence that TRAIL-R4 can also exhibit, in a ligand independent…
The skeleton of the staghorn coral Acropora millepora: molecular and structural characterization.
2014
15 pages; International audience; The scleractinian coral Acropora millepora is one of the most studied species from the Great Barrier Reef. This species has been used to understand evolutionary, immune and developmental processes in cnidarians. It has also been subject of several ecological studies in order to elucidate reef responses to environmental changes such as temperature rise and ocean acidification (OA). In these contexts, several nucleic acid resources were made available. When combined to a recent proteomic analysis of the coral skeletal organic matrix (SOM), they enabled the identification of several skeletal matrix proteins, making A. millepora into an emerging model for biomi…
Should we use gait speed in COPD, FEV 1 in frailty and dyspnoea in both?
2016
Frailty is a progressive physiological decline in multiple organ systems marked by loss of function, loss of physiological reserve and increased vulnerability to disease [1]. Biological (inflammation and loss of hormones), clinical ( e.g. sarcopenia and osteoporosis) and social factors are involved in frailty onset, evolution and prognosis [2, 3]. Links between frailty, dyspnoea and chronic respiratory diseases represent a novel and practical approach
Frailty Assessment in a Stable COPD Cohort: Is There a COPD-Frail Phenotype?
2021
The frailty syndrome increases the morbidity/mortality in older adults, and several studies have shown a higher prevalence of this syndrome in patients with Chronic Obstructive Pulmonary Disease (COPD). The aim of this study was to identify the characteristics of frail patients with COPD to define a new phenotype called "COPD-frail." We conducted a cross-sectional study in a cohort of patients with stable COPD, classified as either frail, pre-frail, or non-frail. Sociodemographic, clinical, and biochemical variables were compared between the three groups of patients. The study included 127 patients, of which 31 were frail, 64 were pre-frail, and 32 non-frail. All subjects had FEV1/FVC below…
Multidimensional frailty and quality of life: data from the English Longitudinal Study of Ageing
2022
Abstract Purpose Frailty has been found to be associated with poor quality of life (QoL) in older people, but data available are limited to cross-sectional studies. We therefore aimed to assess the association between multidimensional frailty, determined by Multidimensional Prognostic Index (MPI), with mortality and good QoL expectancy (GQoLE) in a large representative sample of older adults, over 10 years of follow-up. Methods In the English Longitudinal Study of Ageing, using the data from 2004–2005 and 2014–2015, MPI was calculated using a weighted score of domains of comprehensive geriatric assessment, i.e., number of difficulties in activities of daily living (ADL) and instrumental ADL…
A new type of railway monoblock sleeper
2012
A railway sleeper is the structural element which transversally connects the two rails by means of fastening components, thus ensuring its gauge. Its additional function is to firmly secure the track to the ballast and to distribute the loads transferred from railway carriages to the ballast. One of the most important parameters in the characterisation of performances given by railway sleepers is represented by their lateral resistance to the sliding: the higher its value increases, the better the track stability becomes, thus reducing the frequency of maintenance interventions necessary to keep the superstructure efficient. This article focuses on the performance profile of an innovative r…
A MARKOVIAN MODEL AS A TOOL FOR OPTIMISATION OF MAINTENANCE INTERVENTIONS ON RAILWAYS LINES
2008
This paper is designed to develop a procedure which defines a planning criterion for railway superstructure maintenance by means of Markov decision processes. This methodology allows to formulate a specific policy which carries out the best configuration of budget allocation (min. Ф), and at the same time to guarantee the highest efficiency level in the railway superstructure. Thanks to the dynamic programming technique applied to decision processes, the report has examined the possibility of establishing the best management policy in order to maintain adequate safety levels of implementation and quality speed levels, in the presence of budget constraints, thus optimizing the available re…
Seeking the Holy Grail: robust chronologies from archaeology and radiocarbon dating combined
2018
The strengths of formal Bayesian chronological modelling are restated, combining as it does knowledge of the archaeology with the radiocarbon dating of carefully chosen samples of known taphonomy in association with diagnostic material culture. The risks of dating bone samples are reviewed, along with a brief history of the development of approaches to the radiocarbon dating of bone. In reply to Strien (2017), selected topics concerned with the emergence and aftermath of the LBK are discussed, as well as the early Vinča, Ražište and Hinkelstein sequences. The need for rigour in an approach which combines archaeology and radiocarbon dating is underlined.
Nekustamā īpašuma atsavināšanas sabiedrības vajadzībām tiesiskā regulējuma saturs, tā piemērošana realizējot “Rail Baltica” projektu
2018
Latvijā ir paredzēts veikt valsts vēsturē lielāko nekustamo īpašumu atsavināšanu. Tās mērķis ir nodrošināt dzelzceļa līnijas “Rail Baltica” izbūvi Latvijas teritorijā. Pētījuma mērķis ir analizēt tiesības uz īpašumu aizsardzību, kritērijus, kas pieļauj aizsardzības izņēmumus. Kā arī analizēt šobrīd pastāvošā nekustamā īpašuma atsavināšanas tiesiskā regulējuma efektivitāti, aplūkojot to kopsakarā ar nekustamo īpašumu atsavināšanu “Rail Baltica” projekta vajadzībām. Iegūtie rezultāti norāda uz nepietiekami efektīvu pašreizējo tiesisko regulējumu. Pētījumā ir identificēti tā trūkumi un sniegti priekšlikumi par nepieciešamajiem grozījumiem tiesību aktos.
Rail track field testing using laser/air hybrid ultrasonic technique
2003
Nondestructive testing methods used for the testing of rail in tracks worldwide can be limited by discontinuity location or orientation within the rail. Vertical split head and rail base cracks are among those types of discontinuities that are difficult to detect, which in some cases may result in a reail failure in service. A noncontact and remote hybrid ultrasonic technique has been developed by combining laser generation with air coupled detection of ultrasonic signals in rails. The test apparatus mounts on a railroad pushcart and tests are performed in motion with all components kept above the running surface of the rail track. Tracks have been tested for vertical split head and rail ba…