Search results for "RAIL"

The synthetic cannabinoid WIN sensitizes hepatocellular carcinoma cells to TRAIL-induced apoptosis by activating p8/CHOP/DR5 axis.

2010

In this paper we demonstrate that the synthetic cannabinoid WIN sensitizes human hepatocellular carcinoma (HCC) cells to apoptosis mediated by TNF-related apoptosis inducing ligand (TRAIL). The apoptotic mechanism induced by treatment with WIN/TRAIL combination involved the loss of the mitochondrial transmembrane potential and led to the activation of caspases. In HCC cells WIN treatment induced up-regulation of TRAIL death receptor DR5, an effect which seemed to be related to the increase in the level of p8 and CHOP, two factors implicated in cellular stress response and apoptosis. This relationship was suggested by the observation that the down-regulation of p8 or CHOP by specific siRNAs …

Indagine sperimentale sui segnali sonori all’interno dei rotabili per la diagnosi dello stato dell’armamento ferroviario

2003

The maintenance of track provides an relatively frequent operations. A good maintenance-planning allows to reduce the interference between rail traffic and maintenance operations. It is necessary so to use a monitoring system of track conditions. In this paper is showed an indirect monitoring system that correlates track conditions and typical spectrum of in-cab noise. The first results of experimental survey are reported.

Criteria for Laboratory Studies on Fine Soils Treated with Lime

2011

When selecting the appropriate materials for constructing road infrastructures, an important way for minimizing both the economical and environmental impact is to make use of lime for treating those natural soils that, involved in the earthwork for opening road fences, are not suitable, as they are in nature, to fulfill the specific requirements for being used as part of road construction, such as road embankments (including the capping layer) or the improved subgrade or, again, the sub-formation. From this point of view, the treatment of fine soils with lime (if needed, with lime and cement) can be considered as one of the main measures for preserving the natural environment since it fulfi…

EXPERIMENTAL INVESTIGATION ON DRY ASPHALT RUBBER FOR SUBBALLAST

2011

The asphalt rubber mixes have a wide application field in the railroad and road superstructures because of their technical and environmental properties. While in many countries the wet process is often used to make bituminous mixtures, the dry process doesn’t have the same degree of application even though a larger recycling of waste tires rubber is allowed than the dry process. This paper focuses on the mix-design of the Dry Asphalt Rubber (DAR) for subballast of the railroad superstructure in order to define a sound laboratory procedure of mix-design with reference to Marshall test and Superpave Gyratory Compactor (SGC) test. The comparison between Marshall test and SGC test highlights th…

Stato dell’arte degli interventi sulla sorgente per la mitigazione delle vibrazioni generate da sistemi di trasporto su ferro

2008

La crescente esigenza di mobilità registrata negli ultimi anni in molte città italiane ha condotto all’elaborazione di importanti progetti per la realizzazione, o l’ampliamento, di reti di trasporto di massa in ambito urbano. In molti casi le scelte progettuali prevedono la realizzazione di infrastrutture su ferro, come tram, metropolitana, o ferrovia urbana. Tuttavia, soprattutto nelle città caratterizzate da importanti patrimoni edilizi storici, la realizzazione di tali tipologie infrastrutturali comporta enormi problemi di inserimento ambientale dovuti agli impatti acustici e vibrazionali prodotti dall’esercizio dei vettori. Un caso emblematico che ha mobilitato l’attenzione pubblica, na…

A markovian model as a tool for optimization of maintenance planning on the railway lines

2008

This paper is designed to develop a procedure which defines a planning criterion for railway superstructure maintenance by means of Markov decision processes. This methodology allows to formulate a specific policy π which carries out the best configuration of budget allocation (min. Ф), and at the same time to guarantee the highest efficiency level in the railway superstructure. Thanks to the dynamic programming technique applied to decision processes, the report has examined the possibility of establishing the best management policy in order to maintain adequate safety levels of implementation and quality speed levels, in the presence of budget constraints, thus optimizing the available re…

The interaction between rail stations and urban area in medium-sized towns. A case study for Trapani.

2012

L'Alta Velocità in Cina. Politiche, strategie, territori

2014

High Speed railways in China. Policies, strategies and territories. by Marc Guigon The history of High-Speed railways in China is not a linear one, traced in the course of a rigorous planning process. It has on the contrary experienced moments of rapid surge, only to be followed by periods of slower growth. Fervid action, decision-making and euphoria have been accompanied by scathing failures, against a background of corruption and complex relations with the foreign providers of fundamental technology. The ! nal result is noteworthy however, because China currently has the largest High-Speed railroad network in the world, with a very high level of customer satisfaction, though the cost has …

L'infrastruttura scomparsa. Il nuovo suolo della stazione Sagrera Alta Velocità a Barcellona

2014

The vanishing infrastructure. The new ground of the Sagrera High-Speed railway station in Barcelona The current railway station mega-project in Barcelona Sagrera highlights the link between the construction of the new High- Speed station and a vast linear park that will cover the existing railroad tracks. In the framework of one of the largest and most ambitious railway and urban redevelopment projects currently underway in all of Europe, this article focuses on the subordination of the Station to the park, which apart from being a mere issue of location (the station is literally under the park), can be reframed within a theoretical debate on the role of architecture in these truly signific…

Trasporti, cultura, architettura: presentazione del numero 38 di T&C a Palermo

2015

L'articolo fornisce un contributo al chiarimento del rapporto che il progetto dell’edificio di infrastruttura ha oggi con la città contemporanea e, al tempo stesso, con le questioni disciplinari in cui si inquadra. Contribuendo alla sintesi di conoscenze e orizzonti progettuali a lungo ritenuti incompatibili, il nuovo intenso scambio fra le infrastrutture dei trasporti e l'architettura degli edifici e della città segna il periodo contemporaneo. The article adresses the relationship between infrastructural buildings and architectural design in contemporary urban setting, moreover looking at the disciplinary realignement in which this relaionship is framed. Contributing to the synthesis of kn…