Search results for "RAIL"
showing 10 items of 699 documents
Bioimpedance: a new approach for studying longevity
2017
Centenarians are the best model to study successful ageing. Unfortunately, they are rare and do not have an aged-matched control population to compare their exceptional characteristics with non-longevous people. Considering the complexity of molecular studies, the opportunity to analyse the centenarian phenotype with anthropometry could be an easy and no invasive interesting solution to identify peculiar measurable variables. In addition to the classic measurements, the bioelectrical impedance could be considered. This method permits to analyse the body composition, in terms of fat free mass and fat mass. Ageing is related to reduced fat free mass and increased body fat. The reduction of th…
BPCO E OSTEOPOROSI
2013
COPD and osteoporosis are frequently associated because they have common risk factors, including age, smoking habits and reduced physical activity. COPD is also characterized by systemic inflammation, malnutrition (up to cachexia), hypovitaminosis D, and the use of local and systemic corticosteroids, all of which could cause deterioration in bone quality with a consequent increase in fragility fractures. These fractures may further impair mobility and increase disability and mortality. The vertebral and rib fractures can directly further affect lung function and promote exacerbations. As a result, the assessment of fracture risk in patients with COPD is of vital importance from the earliest…
GLUCOSE CONTROL IN THE OLDER PATIENT: FROM INTENSIVE CONTROL TO EFFECTIVE AND SAFE CONTROL
2009
IL PAZIENTE ANZIANO CON FRATTURA DI FEMORE: VALUTAZIONE E SUPPORTO NUTRIZIONALE
2013
Osteoporosis in the elderly population is a major health problem worldwide, because it is associated with fragility fractures with consequent financial burden for health systems. Europe and North America are the regions where half of all hip fractures among elderly people occurred today, with Scandinavian countries reporting the highest incidence worldwide. Undernutrition, particularly protein malnutrition, is frequent in elderly with osteoporotic hip fracture, although, the role of dietary protein intake in osteoporosis remains controversial. Poor nutritional status is associated with higher comorbidity indices, mortality and readmissions in patients with femoral fracture. Another crucial …
PROTEIN SUPPLEMENTATION IN FRAIL OLDER PERSONS: OFTEN NECESSARY BUT NOT ALWAYS SUFFICIENT
2012
TERAPIA DELLA SARCOPENIA
2014
La sarcopenia e la cachessia sono i disordini muscolari più comune negli adulti. La principale differenza tra le due condizioni è che, a livello istologico, la sarcopenia rappresenta una condizione età correlata che si accompagna a neurodegenerazione, mentre la cachessia è una malattia infiammatoria del muscolo, che è associata a perdita di tessuto adiposo e ad anoressia. E’ stato dimostrato che entrambe le condizioni, nonostante le differenze nella etiologia e fisiopatologia, rispondono positivamente a trattamenti che aumentano la massa e la forza muscolare. Il gold standard attuale della terapia della sarcopenia è l'esercizio fisico. Inoltre, esistono una serie di farmaci che sono disponi…
Sistēmas lietotāju darbību ierakstu žurnāls
2019
Kvalifikācijas darbā "Sistēmas lietotāju darbību ierakstu žurnāls" ir aprakstīta elektroniskās darba laika uzskaites sistēmas EDLUS apakšsadaļas izstrāde. Šī sistēma ir jau pastāvoša un tiek izmantota dažādos un Latvijā esošos objektos. Apakšsadaļas galvenais izstrādes mērķis bija izstrādāt ierakstu žurnālu, kurā sistēmas administratori varētu pārskatīt lietotāju veiktās darbības un izmaiņas. Tas tika īstenots, veidojot EDLUS sistēmas apakšsadaļu ar ierakstiem un to sīkāku aprakstu, kas būtu saprotami administratoriem. Kvalifikācijas darbs satur dokumentāciju par izstrādāto apakšsadaļu - programmatūras prasību specifikāciju, programmatūras projektējuma aprakstu un citas nodaļas.
Research of prognostic biomarkers in Tunisian patients with bladder cancer
2016
Bladder cancer is the first most common urogenital cancer in men in Tunisia, with a high recurrence rate. Patients with muscle-invasive disease develop metastasis. The need for expensive continuous surveillance. In this thesis we try to search some candidate biomarkers. Their use for cancer staging and personalization of therapy at the time of diagnosis in order to identify a better treatment could improve patient care. The aim of this first part of our study was to investigate the clinical significance of three immune cell-related transcription factors, T-bet, GATA-3 and Bcl-6 in Tunisian patients with bladder cancer. We found that T-bet level was significantly higher in invasive carcinoma…
Ramucirumab in elderly patients with hepatocellular carcinoma and elevated alpha-fetoprotein after sorafenib in REACH and REACH-2.
2020
Background & Aims: Limited data on treatment of elderly patients with hepatocellular carcinoma (HCC) increase the unmet need. REACH and REACH-2 were global phase III studies of ramucirumab in patients with HCC after prior sorafenib, where patients with alpha-fetoprotein (AFP) ≥400 ng/mL showed an overall ssurvival (OS) benefit for ramucirumab. These post-hoc analyses examined efficacy and safety of ramucirumab in patients with HCC and baseline AFP ≥ 400 ng/mL by three prespecified age subgroups (<65, ≥65 to <75 and ≥75 years). Methods: Individual patient data were pooled from REACH (baseline AFP ≥400 ng/mL) and REACH-2. Kaplan-Meier and Cox proportional hazards regression methods …
La rete ferroviaria ad Alta Velocità in Corea del Sud [The High-Speed Rail network in South Korea]
2012
LA RETE FERROVIARIA AD ALTA VELOCITA’ IN COREA DEL SUD High speed rail in South Korea